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WRAP53 WD repeat containing, antisense to TP53 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu16517 NM_001143992 Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu16517 NM_001143990 Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu16517 NM_001143991 Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu16517 NM_018081 Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu16517C NM_001143992 Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 4, mRNA. Customized vector On-demand 7-9 $269.00
OHu16517C NM_001143990 Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu16517C NM_001143991 Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu16517C NM_018081 Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol WRAP53
Entrez Gene ID 55135
Full Name WD repeat containing, antisense to TP53
Synonyms DKCB3, TCAB1, WDR79
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13.1

Summary This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011].
Disorder

MIM: 612661

mRNA Protein Product Sequence Price Select
NM_001143990, 221136857 NP_001137462, 221136858 telomerase Cajal body protein 1 ORF Sequence $550.00
NM_001143991, 221136861 NP_001137463, 221136862 telomerase Cajal body protein 1 ORF Sequence $550.00
NM_001143992, 221136865 NP_001137464, 221136866 telomerase Cajal body protein 1 ORF Sequence $550.00
NM_018081, 221136853 NP_060551, 221136854 telomerase Cajal body protein 1 ORF Sequence $550.00
Reactome
REACT_7970Telomere Maintenance
REACT_8030Extension of Telomeres
REACT_7974Telomere Extension By Telomerase
REACT_22172Chromosome Maintenance
REACT_115566Cell Cycle
Homo sapiens (human)WRAP53NP_001137462.1
Pan troglodytes (chimpanzee)WRAP53XP_001172037.1
Macaca mulatta (Rhesus monkey)WRAP53XP_001110427.1
Canis lupus familiaris (dog)WRAP53XP_005620047.1
Bos taurus (cattle)WRAP53NP_001030245.1
Mus musculus (house mouse)Wrap53NP_659073.1
Rattus norvegicus (Norway rat)Wrap53NP_001007611.1
Danio rerio (zebrafish)wrap53NP_001242957.1
Drosophila melanogaster (fruit fly)WDR79NP_608997.3
Arabidopsis thaliana (thale cress)AT4G21520NP_193883.2
Process
IDNameEvidence
GO:0032203telomere formation via telomeraseIMP
GO:0051973positive regulation of telomerase activityIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005697telomerase holoenzyme complexIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0015030Cajal bodyIDA
Function
IDNameEvidence
GO:0003723RNA bindingIDA
GO:0005515protein bindingIPI
GeneCards WRAP53
UniProt Q9BUR4
Vega OTTHUMG00000134323
MIM 612661
Ensembl ENSG00000141499
HGNC 25522
HPRD 07670

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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