Sequence in raw or FASTA format:
WRAP53 WD repeat containing, antisense to TP53 [
Homo sapiens (human)]
Gene Symbol WRAP53
Entrez Gene ID
Full Name WD repeat containing, antisense to TP53
Synonyms DKCB3, TCAB1, WDR79
General protein information
Gene Type protein-coding
Homo sapiens (human)
Chromosome:17 Map Location:17p13.1
Summary This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011].
ID Name Evidence
GO:0032203 telomere formation via telomerase IMP
GO:0051973 positive regulation of telomerase activity IDA
Related articles in PubMed A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629. WRAP53 is an independent prognostic factor in rectal cancer- a study of Swedish clinical trial of preoperative radiotherapy in rectal cancer patients. Zhang H, et al. BMC Cancer, 2012 Jul 17. PMID 22805008. Telomerase recruitment requires both TCAB1 and Cajal bodies independently. Stern JL, et al. Mol Cell Biol, 2012 Jul. PMID 22547674. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094. Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms. Bug M, et al. Oncogene, 2011 Aug 18. PMID 21441950. See all (30) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
Examined expression of WRAP53 protein in rectal cancers and analyzed its relationship to the response to preoperative radiotherapy and patient survival.In radiotherapy group, positive WRAP53 in the metastasis correlated with better survival.
Title: WRAP53 is an independent prognostic factor in rectal cancer- a study of Swedish clinical trial of preoperative radiotherapy in rectal cancer patients.
although Cajal bodies are important for recruitment of telomerase, TCAB1 has an additional role in this process that is independent of these structures
Title: Telomerase recruitment requires both TCAB1 and Cajal bodies independently.
Knockdown of the WRAP53 protein triggers massive apoptosis through the mitochondrial pathway.
Title: WRAP53 promotes cancer cell survival and is a potential target for cancer therapy.
WRAP53 mediates the interaction between SMN and associated proteins, which is important for nuclear targeting of SMN and the subsequent localization of the SMN complex to Cajal bodies
Title: WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies.
Compound heterozygous mutations in TCAB1 disrupt telomerase localization to Cajal bodies, resulting in misdirection of telomerase RNA to nucleoli, which prevents telomerase from elongating telomeres
Title: Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita.
Studies show that a linked, positively selected allele at the nearby gene WDR79 may be partly responsible for the sequence diversity profile of TP53.
Title: The diversity profile of TP53 is influenced by positive selection on the immediately upstream locus WDR79.
We have identified a natural antisense transcript of p53, designated Wrap53, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA.
Title: Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage.
identification of telomerase holoenzyme subunit, TCAB1, enriched in Cajal bodies; it associates with active telomerase, telomerase components & small Cajal body RNAs; TCAB1 controls telomerase trafficking & required for telomere synthesis in cancer cells
Title: A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic susceptibility to distinct bladder cancer subphenotypes.
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