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NOP10 NOP10 ribonucleoprotein [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_018648 Homo sapiens NOP10 ribonucleoprotein (NOP10), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

*Business Day

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Gene Symbol NOP10
Entrez Gene ID 55505
Full Name NOP10 ribonucleoprotein
Synonyms DKCB1, NOLA3, NOP10P
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q14-q15

Summary This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008].
Disorder

MIM: 606471

Dyskeratosis congenita, autosomal recessive, 224230 (3)

mRNA Protein Product Sequence Price Select
NM_018648, 77812675 NP_061118, 8923942 H/ACA ribonucleoprotein complex subunit 3 ORF Sequence $99.00
KEGG
hsa03008Ribosome biogenesis in eukaryotes
hsa_M00425H/ACA ribonucleoprotein complex
Homo sapiens (human)NOP10NP_061118.1
Pan troglodytes (chimpanzee)NOP10XP_001165824.1
Canis lupus familiaris (dog)NOP10XP_849017.2
Bos taurus (cattle)NOP10NP_001107993.1
Mus musculus (house mouse)Nop10NP_079679.1
Rattus norvegicus (Norway rat)Nop10NP_001119572.1
Danio rerio (zebrafish)nop10NP_001003868.1
Drosophila melanogaster (fruit fly)CG7637NP_610610.1
Xenopus (Silurana) tropicalis (western clawed frog)nop10NP_001016163.1
Process
IDNameEvidence
GO:0001522pseudouridine synthesisNAS
GO:0006364rRNA processingIEA
Component
IDNameEvidence
GO:0005730nucleolusIEA
GO:0005732small nucleolar ribonucleoprotein complexTAS
GO:0015030Cajal bodyIEA
GO:0072588box H/ACA RNP complexIEA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0030515snoRNA bindingIEA
GeneCards NOP10
UniProt Q9NPE3
Vega OTTHUMG00000129440
MIM 606471
Ensembl ENSG00000182117
HGNC 14378
HPRD 07571

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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