Sequence in raw or FASTA format:
SLC30A10 solute carrier family 30, member 10 [Homo sapiens (human)]
|Entrez Gene ID||55532|
|Full Name||solute carrier family 30, member 10|
|Synonyms||HMDPC, ZNT10, ZNT8, ZRC1, ZnT-10|
|General protein information|
|Organism||Homo sapiens (human)|
|Summary||This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012].|
|Homo sapiens (human)||SLC30A10||NP_061183.2|
|Pan troglodytes (chimpanzee)||SLC30A10||XP_525065.1|
|Macaca mulatta (Rhesus monkey)||SLC30A10||XP_001103570.1|
|Bos taurus (cattle)||SLC30A10||NP_001179109.1|
|Mus musculus (house mouse)||Slc30a10||NP_001028458.1|
|Rattus norvegicus (Norway rat)||Slc30a10||NP_001099455.1|
|Gallus gallus (chicken)||SLC30A10||XP_419410.3|
|Danio rerio (zebrafish)||slc30a10||NP_001121706.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||slc30a10||XP_002936066.2|
|GO:0006829||zinc ion transport||IEA|
|GO:0016021||integral component of membrane||IEA|
|GO:0008324||cation transmembrane transporter activity||IEA|
What is the normal function of the SLC30A10 gene?
The SLC30A10 gene provides instructions for making a protein that transports the element manganese across cell membranes. Manganese is important for many cellular functions, but large amounts are toxic, particularly to brain and liver cells. The SLC30A10 protein is found in the membranes surrounding liver cells and nerve cells in the brain, as well as in the membranes of structures within these cells. The protein protects these cells from high concentrations of manganese by removing manganese when levels become elevated.
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