• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


PRPS1 phosphoribosyl pyrophosphate synthetase 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu21900 NM_001204402 Homo sapiens phosphoribosyl pyrophosphate synthetase 1 (PRPS1), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu26049 NM_002764 Homo sapiens phosphoribosyl pyrophosphate synthetase 1 (PRPS1), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu21900C NM_001204402 Homo sapiens phosphoribosyl pyrophosphate synthetase 1 (PRPS1), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu26049C NM_002764 Homo sapiens phosphoribosyl pyrophosphate synthetase 1 (PRPS1), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00

*Business Day

Related Services

Gene Symbol PRPS1
Entrez Gene ID 5631
Full Name phosphoribosyl pyrophosphate synthetase 1
Synonyms ARTS, CMTX5, DFN2, DFNX1, PPRibP, PRS-I, PRSI
General protein information
Preferred Names
ribose-phosphate pyrophosphokinase 1
Names
ribose-phosphate pyrophosphokinase 1
deafness 2, perceptive, congenital
ribose-phosphate diphosphokinase 1
phosphoribosyl pyrophosphate synthase I
deafness, X-linked 2, perceptive, congenital
dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1)
NP_001191331.1
NP_002755.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq22.3

Summary This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
Disorder

MIM: 311850

Gout, PRPS-related, 300661 (3); Phosphoribosylpyrophosphate

mRNA Protein Product Sequence Price Select
NM_001204402, 324711014 NP_001191331, 324711015 ribose-phosphate pyrophosphokinase 1 isoform 2 ORF Sequence $99.00
NM_002764, 164663865 NP_002755, 4506127 ribose-phosphate pyrophosphokinase 1 isoform 1 ORF Sequence $269.00
KEGG
hsa00030Pentose phosphate pathway
hsa00230Purine metabolism
hsa_M00005PRPP biosynthesis, ribose 5P => PRPP
hsa01230Biosynthesis of amino acids
hsa01200Carbon metabolism
WikiPathways
WP404Nucleotide Metabolism
Reactome
REACT_474Metabolism of carbohydrates
REACT_8505-Phosphoribose 1-diphosphate biosynthesis
REACT_111217Metabolism
REACT_116125Disease
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)PRPS1NP_002755.1
Pan troglodytes (chimpanzee)PRPS1XP_001144504.1
Macaca mulatta (Rhesus monkey)PRPS1XP_001095604.1
Canis lupus familiaris (dog)PRPS1XP_005641702.1
Bos taurus (cattle)PRPS1NP_001039654.1
Mus musculus (house mouse)Prps1NP_067438.1
Rattus norvegicus (Norway rat)Prps1NP_058939.1
Gallus gallus (chicken)PRPS1XP_004940671.1
Danio rerio (zebrafish)prps1bNP_001070036.1
Drosophila melanogaster (fruit fly)CG6767NP_729528.2
Arabidopsis thaliana (thale cress)AT2G35390NP_850244.1
Arabidopsis thaliana (thale cress)PRS2NP_174516.1
Arabidopsis thaliana (thale cress)AT2G44530NP_181981.2
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processTAS
GO:00060155-phosphoribose 1-diphosphate biosynthetic processIEA
GO:00060155-phosphoribose 1-diphosphate biosynthetic processTAS
GO:0006144purine nucleobase metabolic processIMP
GO:0006164purine nucleotide biosynthetic processIMP
GO:0006167AMP biosynthetic processIEA
GO:0006221pyrimidine nucleotide biosynthetic processNAS
GO:0007399nervous system developmentIMP
GO:0008219cell deathIEA
GO:0016310phosphorylationIEA
GO:0031100organ regenerationIEA
GO:0034418urate biosynthetic processIMP
GO:0044281small molecule metabolic processTAS
GO:0046101hypoxanthine biosynthetic processIMP
Component
IDNameEvidence
GO:0002189ribose phosphate diphosphokinase complexIEA
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0000287magnesium ion bindingIEA
GO:0004749ribose phosphate diphosphokinase activityEXP
GO:0004749ribose phosphate diphosphokinase activityIDA
GO:0004749ribose phosphate diphosphokinase activityIMP
GO:0005524ATP bindingIDA
GO:0016208AMP bindingIEA
GO:0016301kinase activityIEA
GO:0019003GDP bindingIEA
GO:0030246carbohydrate bindingIEA
GO:0042803protein homodimerization activityIPI
GO:0043531ADP bindingIEA
GeneCards PRPS1
PDB 2H08, 2H07, 3EFH, 2HCR, 2H06, 3S5J, 4F8E
UniProt B7ZB02, P60891
Vega OTTHUMG00000022167
MIM 311850
Ensembl ENSG00000147224
HGNC 9462
HPRD 02413

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.