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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


INPP5E inositol polyphosphate-5-phosphatase, 72 kDa [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu27383 NM_019892 Homo sapiens inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu43395 XM_005266094 PREDICTED: Homo sapiens inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu43396 XM_006717187 PREDICTED: Homo sapiens inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu27383C NM_019892 Homo sapiens inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E), mRNA. Customized vector In-stock 5-7 $149.00
OHu43395C XM_005266094 PREDICTED: Homo sapiens inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu43396C XM_006717187 PREDICTED: Homo sapiens inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol INPP5E
Entrez Gene ID 56623
Full Name inositol polyphosphate-5-phosphatase, 72 kDa
Synonyms CORS1, CPD4, JBTS1, MORMS, PPI5PIV
General protein information
Preferred Names
72 kDa inositol polyphosphate 5-phosphatase
Names
72 kDa inositol polyphosphate 5-phosphatase
phosphatidylinositol 4,5-bisphosphate 5-phosphatase
phosphatidylinositol-4,5-bisphosphate 5-phosphatase
phosphatidylinositol (4,5) bisphosphate 5-phosphatase
phosphatidylinositol polyphosphate 5-phosphatase type IV
NP_063945.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9q34.3

Summary The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.[provided by RefSeq, Feb 2011].
Disorder

MIM: 613037

Mental retardation, truncal obesity, retinal dystrophy, and

mRNA Protein Product Sequence Price Select
NM_019892, 326806964 NP_063945, 38327539 72 kDa inositol polyphosphate 5-phosphatase ORF Sequence $490.00
XM_005266094, 530426766 XP_005266151, 530426767 72 kDa inositol polyphosphate 5-phosphatase isoform X1 ORF Sequence $700.00
XM_006717187, 578817661 XP_006717250, 578817662 72 kDa inositol polyphosphate 5-phosphatase isoform X2 ORF Sequence $700.00
KEGG
hsa00562Inositol phosphate metabolism
hsa04070Phosphatidylinositol signaling system
BIOCYC
HUMAN_PWY-63683-phosphoinositide degradation
Reactome
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
REACT_121175PI Metabolism
REACT_120836Synthesis of PIPs at the Golgi membrane
REACT_120870Phospholipid metabolism
Homo sapiens (human)INPP5ENP_063945.2
Pan troglodytes (chimpanzee)INPP5ENP_001070981.1
Macaca mulatta (Rhesus monkey)INPP5EXP_001095203.1
Canis lupus familiaris (dog)INPP5EXP_005625166.1
Bos taurus (cattle)INPP5ENP_001179019.1
Mus musculus (house mouse)Inpp5eNP_149125.1
Rattus norvegicus (Norway rat)Inpp5eNP_446084.1
Gallus gallus (chicken)INPP5EXP_415418.2
Danio rerio (zebrafish)inpp5eNP_001096089.2
Xenopus (Silurana) tropicalis (western clawed frog)inpp5eXP_002935265.1
Process
IDNameEvidence
GO:0006644phospholipid metabolic processTAS
GO:0006661phosphatidylinositol biosynthetic processTAS
GO:0008150biological_processND
GO:0044281small molecule metabolic processTAS
GO:0046855inositol phosphate dephosphorylationIEA
GO:0046856phosphatidylinositol dephosphorylationIEA
Component
IDNameEvidence
GO:0005829cytosolTAS
GO:0005856cytoskeletonIEA
GO:0005930axonemeIDA
GO:0032580Golgi cisterna membraneIEA
Function
IDNameEvidence
GO:0004439phosphatidylinositol-4,5-bisphosphate 5-phosphatase activityIEA
GO:0004445inositol-polyphosphate 5-phosphatase activityTAS
GeneCards INPP5E
UniProt Q9NRR6
Vega OTTHUMG00000020927
MIM 613037
Ensembl ENSG00000148384
HGNC 21474
HPRD 17151

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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