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INPP5E inositol polyphosphate-5-phosphatase, 72 kDa [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_019892 Homo sapiens inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E), nuclear gene encoding mitochondrial protein, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 TBD

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Gene Symbol INPP5E
Entrez Gene ID 56623
Full Name inositol polyphosphate-5-phosphatase, 72 kDa
Synonyms CORS1, CPD4, JBTS1, MGC117201, MORMS, PPI5PIV
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.[provided by RefSeq, Feb 2011].

MIM: 613037

Mental retardation, truncal obesity, retinal dystrophy, and

mRNA Protein Product Sequence Price Select
NM_019892, 326806964 NP_063945, 38327539 72 kDa inositol polyphosphate 5-phosphatase ORF Sequence $490.00
hsa04070Phosphatidylinositol signaling system
hsa00562Inositol phosphate metabolism
HUMAN_PWY-63683-phosphoinositide degradation
META_PWY-63683-phosphoinositide degradation
REACT_22258Metabolism of lipids and lipoproteins
REACT_120836Synthesis of PIPs at the Golgi membrane
REACT_121175PI Metabolism
REACT_120870Phospholipid metabolism
Homo sapiens (human)INPP5ENP_063945.2
Pan troglodytes (chimpanzee)INPP5ENP_001070981.1
Macaca mulatta (Rhesus monkey)INPP5EXP_001095203.1
Canis lupus familiaris (dog)INPP5EXP_849208.1
Bos taurus (cattle)INPP5ENP_001179019.1
Mus musculus (house mouse)Inpp5eNP_149125.1
Rattus norvegicus (Norway rat)Sec16aXP_002729191.1
Gallus gallus (chicken)INPP5EXP_415418.2
Danio rerio (zebrafish)inpp5eNP_001096089.2
GeneCards INPP5E
UniProt Q9NRR6
MIM 613037
Ensembl ENSG00000148384
HGNC 21474
HPRD 17151

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
72 kDa inositol polyphosphate 5-phosphatase
72 kDa inositol polyphosphate 5-phosphatase
phosphatidylinositol 4,5-bisphosphate 5-phosphatase
phosphatidylinositol-4,5-bisphosphate 5-phosphatase
phosphatidylinositol (4,5) bisphosphate 5-phosphatase
phosphatidylinositol polyphosphate 5-phosphatase type IV


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