PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 [Homo sapiens (human)]
| Gene Symbol | PSMA5 |
| Entrez Gene ID | 5686 |
| Full Name | proteasome (prosome, macropain) subunit, alpha type, 5 |
| Synonyms | FLJ42315, MGC117302, MGC125802, MGC125803, MGC125804, PSC5, ZETA |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p13 |
| Summary | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq]. |
| Disorder | MIM: 176844 |
| mRNA | NM_002790, 315138979 |
| Protein | NP_002781, 23110942 |
| Product | proteasome subunit alpha type-5 isoform 1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001199773, 315138982 |
| Protein | NP_001186702, 315138983 |
| Product | proteasome subunit alpha type-5 isoform 2 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001199774, 315138984 |
| Protein | NP_001186703, 315138985 |
| Product | proteasome subunit alpha type-5 isoform 2 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001199772, 315138980 |
| Protein | NP_001186701, 315138981 |
| Product | proteasome subunit alpha type-5 isoform 2 |
| RefSeq Status | REVIEWED |
| hsa03050 | Proteasome |
WikiPathways
| WP183 | Proteasome Degradation |
Reactome
| REACT_9031 | Vpu mediated degradation of CD4 |
| REACT_152 | Cell Cycle, Mitotic |
| REACT_6954 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| REACT_6781 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| REACT_20605 | Metabolism of mRNA |
| REACT_2148 | Switching of origins to a post-replicative state |
| REACT_6785 | Autodegradation of Cdh1 by Cdh1:APC/C |
| REACT_6185 | HIV Infection |
| REACT_24994 | Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| REACT_13464 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
| REACT_1949 | CDT1 association with the CDC6:ORC:origin complex |
| REACT_11045 | Signaling by Wnt |
| REACT_1221 | CDK-mediated phosphorylation and removal of Cdc6 |
| REACT_1783 | G1/S Transition |
| REACT_2243 | Assembly of the pre-replicative complex |
| REACT_6837 | Regulation of APC/C activators between G1/S and early anaphase |
| REACT_6871 | APC/C:Cdc20 mediated degradation of Securin |
| REACT_25325 | Destabilization of mRNA by AUF1 (hnRNP D0) |
| REACT_6761 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| REACT_9003 | SCF(Skp2)-mediated degradation of p27/p21 |
| REACT_1625 | p53-Dependent G1 DNA Damage Response |
| REACT_9029 | Cyclin A:Cdk2-associated events at S phase entry |
| REACT_21279 | Regulation of mitotic cell cycle |
| REACT_2254 | G1/S DNA Damage Checkpoints |
| REACT_829 | Regulation of DNA replication |
| REACT_383 | DNA Replication |
| REACT_4 | Ubiquitin-dependent degradation of Cyclin D1 |
| REACT_6821 | SCF-beta-TrCP mediated degradation of Emi1 |
| REACT_21267 | Mitotic G1-G1/S phases |
| REACT_21300 | Mitotic M-M/G1 phases |
| REACT_11063 | Degradation of beta-catenin by the destruction complex |
| REACT_6828 | APC/C-mediated degradation of cell cycle proteins |
| REACT_1538 | Cell Cycle Checkpoints |
| REACT_899 | S Phase |
| REACT_2014 | Synthesis of DNA |
| REACT_21257 | Metabolism of RNA |
| REACT_734 | DNA Replication Pre-Initiation |
| REACT_2160 | p53-Independent DNA Damage Response |
| REACT_85 | p53-Dependent G1/S DNA damage checkpoint |
| REACT_578 | Apoptosis |
| REACT_1208 | p53-Independent G1/S DNA damage checkpoint |
| REACT_13648 | Regulation of Apoptosis |
| REACT_1156 | Orc1 removal from chromatin |
| REACT_1614 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A |
| REACT_13 | Metabolism of amino acids and derivatives |
| REACT_207 | Removal of licensing factors from origins |
| REACT_1574 | Cyclin E associated events during G1/S transition |
| REACT_6288 | Host Interactions of HIV factors |
| REACT_1725 | M/G1 Transition |
| REACT_20549 | Autodegradation of the E3 ubiquitin ligase COP1 |
| REACT_13565 | Regulation of ornithine decarboxylase (ODC) |
| REACT_9453 | Vif-mediated degradation of APOBEC3G |
| REACT_309 | Stabilization of p53 |
| REACT_938 | Ubiquitin-dependent degradation of Cyclin D |
| Homo sapiens (human) | PSMA5 | NP_002781.2 |
| Canis lupus familiaris (dog) | PSMA5 | XP_547244.2 |
| Bos taurus (cattle) | PSMA5 | NP_001015566.1 |
| Mus musculus (house mouse) | Psma5 | NP_036097.1 |
| Rattus norvegicus (Norway rat) | Psma5 | NP_058978.1 |
| Gallus gallus (chicken) | PSMA5 | NP_001026578.1 |
| Danio rerio (zebrafish) | psma5 | NP_991271.1 |
| Drosophila melanogaster (fruit fly) | Prosalpha5 | NP_477202.2 |
| Caenorhabditis elegans | pas-5 | NP_492765.1 |
| Arabidopsis thaliana (thale cress) | PAE2 | NP_188046.1 |
| Arabidopsis thaliana (thale cress) | PAE1 | NP_001077717.1 |
| ID | Name | Evidence |
| GO:0000075 | cell cycle checkpoint | TAS |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS |
| GO:0000084 | S phase of mitotic cell cycle | TAS |
| GO:0000216 | M/G1 transition of mitotic cell cycle | TAS |
| GO:0000278 | mitotic cell cycle | TAS |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA |
| GO:0006521 | regulation of cellular amino acid metabolic process | TAS |
| GO:0006915 | apoptosis | TAS |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | TAS |
| GO:0016032 | viral reproduction | TAS |
| GO:0016070 | RNA metabolic process | TAS |
| GO:0016071 | mRNA metabolic process | TAS |
| GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | EXP |
| GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | TAS |
| GO:0034641 | cellular nitrogen compound metabolic process | TAS |
| GO:0042981 | regulation of apoptosis | TAS |
| GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | EXP |
| GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | EXP |
| GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS |
| GO:0051603 | proteolysis involved in cellular protein catabolic process | IEA |
Component
| ID | Name | Evidence |
| GO:0000502 | proteasome complex | TAS |
| GO:0005634 | nucleus | IEA |
| GO:0005737 | cytoplasm | IEA |
| GO:0019773 | proteasome core complex, alpha-subunit complex | IEA |
Function
| ID | Name | Evidence |
| GO:0004298 | threonine-type endopeptidase activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0008233 | peptidase activity | IEA |
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