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PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001199772 Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 5 (PSMA5), transcript variant 2, mRNA. ORF Sequence $160.08
Peptide Services
Antibody Services
Protein Services
NM_001199773 Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 5 (PSMA5), transcript variant 3, mRNA. ORF Sequence $160.08
Peptide Services
Antibody Services
Protein Services
NM_001199774 Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 5 (PSMA5), transcript variant 4, mRNA. ORF Sequence $160.08
Peptide Services
Antibody Services
Protein Services
NM_002790 Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 5 (PSMA5), transcript variant 1, mRNA. ORF Sequence $210.54
Peptide Services
Antibody Services
Protein Services


Gene Symbol PSMA5
Entrez Gene ID 5686
Full Name proteasome (prosome, macropain) subunit, alpha type, 5
Synonyms FLJ42315, MGC117302, MGC125802, MGC125803, MGC125804, PSC5, ZETA
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p13

Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010].
Disorder

MIM: 176844

mRNA Protein Product Sequence Price Select
NM_001199772, 315138980 NP_001186701, 315138981 proteasome subunit alpha type-5 isoform 2 Full Length $1319.85
ORF Sequence $160.08
NM_001199773, 315138982 NP_001186702, 315138983 proteasome subunit alpha type-5 isoform 2 Full Length $1311.10
ORF Sequence $160.08
NM_001199774, 315138984 NP_001186703, 315138985 proteasome subunit alpha type-5 isoform 2 Full Length $1315.30
ORF Sequence $160.08
NM_002790, 315138979 NP_002781, 23110942 proteasome subunit alpha type-5 isoform 1 Full Length $1343.30
ORF Sequence $210.54
KEGG
hsa_M00337Immunoproteasome
hsa03050Proteasome
hsa_M00340Proteasome, 20S core particle
WikiPathways
WP183Proteasome Degradation
Reactome
REACT_1208p53-Independent G1/S DNA damage checkpoint
REACT_1156Orc1 removal from chromatin
REACT_20549Autodegradation of the E3 ubiquitin ligase COP1
REACT_111217Metabolism
REACT_1574Cyclin E associated events during G1/S transition
REACT_938Ubiquitin-dependent degradation of Cyclin D
REACT_6288Host Interactions of HIV factors
REACT_1725M/G1 Transition
REACT_13Metabolism of amino acids and derivatives
REACT_309Stabilization of p53
REACT_1614Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
REACT_6954Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_111102Signal Transduction
REACT_2148Switching of origins to a post-replicative state
REACT_207Removal of licensing factors from origins
REACT_111119Antigen processing-Cross presentation
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_115566Cell Cycle
REACT_13648Regulation of Apoptosis
REACT_6785Autodegradation of Cdh1 by Cdh1:APC/C
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_1221CDK-mediated phosphorylation and removal of Cdc6
REACT_1783G1/S Transition
REACT_13464Regulation of activated PAK-2p34 by proteasome mediated degradation
REACT_118656Activation of NF-kappaB in B Cells
REACT_13565Regulation of ornithine decarboxylase (ODC)
REACT_24994Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
REACT_9453Vif-mediated degradation of APOBEC3G
REACT_75774Adaptive Immune System
REACT_21279Regulation of mitotic cell cycle
REACT_9031Vpu mediated degradation of CD4
REACT_2243Assembly of the pre-replicative complex
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_1625p53-Dependent G1 DNA Damage Response
REACT_111056Cross-presentation of soluble exogenous antigens (endosomes)
REACT_71Gene Expression
REACT_152Cell Cycle, Mitotic
REACT_6761APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
REACT_9003SCF(Skp2)-mediated degradation of p27/p21
REACT_383DNA Replication
REACT_6781APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_6185HIV Infection
REACT_1949CDT1 association with the CDC6:ORC:origin complex
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_6821SCF-beta-TrCP mediated degradation of Emi1
REACT_111178ER-Phagosome pathway
REACT_11045Signaling by Wnt
REACT_25325Destabilization of mRNA by AUF1 (hnRNP D0)
REACT_9029Cyclin A:Cdk2-associated events at S phase entry
REACT_6871APC/C:Cdc20 mediated degradation of Securin
REACT_829Regulation of DNA replication
REACT_2254G1/S DNA Damage Checkpoints
REACT_4Ubiquitin-dependent degradation of Cyclin D1
REACT_116125Disease
REACT_21267Mitotic G1-G1/S phases
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_21300Mitotic M-M/G1 phases
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_1538Cell Cycle Checkpoints
REACT_899S Phase
REACT_2014Synthesis of DNA
REACT_734DNA Replication Pre-Initiation
REACT_2160p53-Independent DNA Damage Response
REACT_85p53-Dependent G1/S DNA damage checkpoint
REACT_578Apoptosis
REACT_6900Immune System
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
Homo sapiens (human)PSMA5NP_002781.2
Pan troglodytes (chimpanzee)LOC469795XP_525179.3
Macaca mulatta (Rhesus monkey)PSMA5XP_001090512.1
Canis lupus familiaris (dog)LOC100856348XP_003639184.1
Bos taurus (cattle)PSMA5NP_001015566.1
Mus musculus (house mouse)Psma5NP_036097.1
Rattus norvegicus (Norway rat)Psma5NP_058978.1
Gallus gallus (chicken)PSMA5NP_001026578.1
Danio rerio (zebrafish)psma5NP_991271.1
Drosophila melanogaster (fruit fly)Prosalpha5NP_477202.2
Caenorhabditis eleganspas-5NP_492765.1
Arabidopsis thaliana (thale cress)PAE2NP_188046.1
Arabidopsis thaliana (thale cress)PAE1NP_001077717.1
GeneCards PSMA5
UniProt P28066
MIM 176844
Ensembl ENSG00000143106
HGNC 9534
HPRD 01464

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
proteasome subunit alpha type-5
Names
proteasome subunit alpha type-5
macropain zeta chain
proteasome zeta chain
macropain subunit zeta
proteasome component 5
proteasome subunit zeta
proteasome alpha 5 subunit
multicatalytic endopeptidase complex zeta chain
NP_001186701.1
NP_001186702.1
NP_001186703.1
NP_002781.2

Interactant

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