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PTH parathyroid hormone [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	PTH
Entrez Gene ID	5741
Full Name	parathyroid hormone
Synonyms	PTH1
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:11 Map Location:11p15.3-p15.1
Summary	The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq].
Disorder	MIM: 168450 Hypoparathyroidism, autosomal dominant, 146200 (3);

mRNA	NM_000315, 39995098
Protein	NP_000306, 4506267
Product	parathyroid hormone preproprotein
RefSeq Status	REVIEWED

WikiPathways

WP322	Osteoblast Signaling
WP474	Endochondral Ossification

Reactome

REACT_21340	GPCR ligand binding
REACT_19184	GPCR downstream signaling
REACT_18372	Class B/2 (Secretin family receptors)
REACT_14797	Signaling by GPCR
REACT_19327	G alpha (s) signalling events

Homo sapiens (human)	PTH	NP_000306.1
Pan troglodytes (chimpanzee)	PTH	XP_001171819.1
Canis lupus familiaris (dog)	PTH	NP_001003302.1
Bos taurus (cattle)	PTH	NP_776379.2
Mus musculus (house mouse)	Pth	NP_065648.1
Rattus norvegicus (Norway rat)	Pth	NP_058740.1
Gallus gallus (chicken)	PTH	NP_990783.1

Process

ID	Name	Evidence
GO:0001501	skeletal system development	TAS
GO:0006874	cellular calcium ion homeostasis	NAS
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS
GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	IEA
GO:0007266	Rho protein signal transduction	IEA
GO:0007267	cell-cell signaling	TAS
GO:0008628	induction of apoptosis by hormones	TAS
GO:0009967	positive regulation of signal transduction	IEA
GO:0010468	regulation of gene expression	IDA
GO:0030819	positive regulation of cAMP biosynthetic process	IDA
GO:0034645	cellular macromolecule biosynthetic process	IDA
GO:0045453	bone resorption	NAS
GO:0045725	positive regulation of glycogen biosynthetic process	IDA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA
GO:0046058	cAMP metabolic process	TAS
GO:0046326	positive regulation of glucose import	IDA

Component

ID	Name	Evidence
GO:0005576	extracellular region	EXP
GO:0005576	extracellular region	NAS
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IEA

Function

ID	Name	Evidence
GO:0005179	hormone activity	IEA
GO:0031856	parathyroid hormone receptor binding	IEA
GO:0051428	peptide hormone receptor binding	IDA

GeneCards	PTH
PDB	1ZWF, 1HPY, 1ZWG, 1ET2, 1HTH, 1BWX, 1ZWA, 1ZWE, 1ZWB, 1FVY, 1ZWD, 3C4M, 1ET1, 1HPH
UniProt	P01270
MIM	168450
Ensembl	ENSG00000152266
HGNC	9606
HPRD	01345

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