Sequence in raw or FASTA format:
XPO5 exportin 5 [
Homo sapiens (human)]
Gene Symbol XPO5
Entrez Gene ID
Full Name exportin 5
General protein information
ran-binding protein 21
Gene Type protein-coding
Homo sapiens (human)
Chromosome:6 Map Location:6p21.1
Summary This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011].
Related articles in PubMed The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. Cox JL, et al. PLoS One, 2013. PMID 23667531. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. Scifo E, et al. J Proteome Res, 2013 May 3. PMID 23464991. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Varjosalo M, et al. Nat Methods, 2013 Apr. PMID 23455922. Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells. Buanne P, et al. J Proteome Res, 2013 Jan 4. PMID 23181366. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. Yatim A, et al. Mol Cell, 2012 Nov 9. PMID 23022380. See all (57) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
Dicer, Drosha, and Exportin 5 genes were up-regulated in bladder urothelial carcinoma compared to normal urothelium. Silencing these genes induced cell proliferation inhibition and apoptosis in bladder urothelial carcinoma cells.
Title: Inducing cell proliferation inhibition and apoptosis via silencing Dicer, Drosha, and Exportin 5 in urothelial carcinoma of the bladder.
overall survival was significantly longer in multiple myeloma patients with C/C or A/C variant in the XPO5 gene single nucleotide polymorphism site rs11077
Title: Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation.
Exportin-5 controls Dicer1 expression post-transcriptionally.
Title: Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels.
Data show a requirement for the export receptor Exportin 5 in nuclear export of 60S subunits in human cells, and that Exp5 binds to pre-60S particles in a RanGTP-dependent manner.
Title: A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export.
The restoration of XPO5 functions reverses the impaired export of pre-miRNAs and has tumor-suppressor features.
Title: A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes.
2.9 angstrom structure of the pre-miRNA nuclear export machinery formed by pre-miRNA complexed with Exp-5 and RanGTP; RNA recognition by Exp-5:RanGTP does not depend on RNA sequence, implying that Exp-5:RanGTP can recognize a variety of pre-miRNAs
Title: A high-resolution structure of the pre-microRNA nuclear export machinery.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
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