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Sequence in raw or FASTA format:

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UVSSA UV-stimulated scaffold protein A [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_020894 Homo sapiens UV-stimulated scaffold protein A (UVSSA), mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005272290 PREDICTED: Homo sapiens UV-stimulated scaffold protein A (UVSSA), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006713897 PREDICTED: Homo sapiens UV-stimulated scaffold protein A (UVSSA), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006713898 PREDICTED: Homo sapiens UV-stimulated scaffold protein A (UVSSA), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006713899 PREDICTED: Homo sapiens UV-stimulated scaffold protein A (UVSSA), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

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Gene Symbol UVSSA
Entrez Gene ID 57654
Full Name UV-stimulated scaffold protein A
Synonyms KIAA1530, UVSS3
General protein information
Preferred Names
UV-stimulated scaffold protein A
Names
UV-stimulated scaffold protein A
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4p16.3

Summary The protein encoded by this gene appears to be involved in ubiquitination and dephosphorylation of RNA polymerase II subunits that stall after UV irradiation. The encoded protein interacts with several members of the nucleotide excision repair complex to help repair UV-induced DNA damage. Defects in this gene can cause UV-sensitive syndrome 3. [provided by RefSeq, May 2012].
Disorder

MIM: 614632

mRNA Protein Product Sequence Price Select
NM_020894, 190358542 NP_065945, 190358543 UV-stimulated scaffold protein A ORF Sequence $700.00
XM_005272290, 578808195 XP_005272347, 530427381 UV-stimulated scaffold protein A isoform X1 ORF Sequence $700.00
XM_006713897, 578808193 XP_006713960, 578808194 UV-stimulated scaffold protein A isoform X2 ORF Sequence $700.00
XM_006713898, 578808196 XP_006713961, 578808197 UV-stimulated scaffold protein A isoform X3 ORF Sequence $700.00
XM_006713899, 578808198 XP_006713962, 578808199 UV-stimulated scaffold protein A isoform X4 ORF Sequence $700.00
Homo sapiens (human)UVSSANP_065945.2
Pan troglodytes (chimpanzee)UVSSAXP_001174295.2
Macaca mulatta (Rhesus monkey)LOC693853XP_001082560.1
Canis lupus familiaris (dog)UVSSAXP_545930.3
Bos taurus (cattle)KIAA1530XP_002688500.3
Mus musculus (house mouse)UvssaNP_001074570.1
Rattus norvegicus (Norway rat)UvssaNP_001128030.1
Gallus gallus (chicken)UVSSAXP_420845.4
Danio rerio (zebrafish)uvssaXP_005157263.1
Xenopus (Silurana) tropicalis (western clawed frog)uvssaNP_001107306.1
Process
IDNameEvidence
GO:0006283transcription-coupled nucleotide-excision repairIMP
GO:0009411response to UVIMP
GO:0016567protein ubiquitinationIMP
Component
IDNameEvidence
GO:0005694chromosomeIDA
Function
IDNameEvidence
GO:0000993RNA polymerase II core bindingIDA
GO:0000993RNA polymerase II core bindingIMP
GO:0005515protein bindingIPI
GeneCards UVSSA
UniProt Q2YD98
Vega OTTHUMG00000160167
MIM 614632
Ensembl ENSG00000163945
HGNC 29304
HPRD 17216

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the UVSSA gene?

The UVSSA gene provides instructions for making a protein that is involved in repairing DNA damaged by ultraviolet (UV) rays from the sun. The damage can block vital cell activities such as gene transcription, which is the first step in protein production. If left uncorrected, DNA damage accumulates, which causes cells to malfunction and can lead to cell death.

Cells have several mechanisms to correct DNA damage. The UVSSA protein is involved in one mechanism that repairs damaged DNA within active genes (those genes undergoing gene transcription). When DNA in active genes is damaged, the enzyme that carries out gene transcription (RNA polymerase) gets stuck, and the process stalls. Researchers think that the UVSSA protein helps remove RNA polymerase from the damaged site, so the DNA can be repaired. Part of the UVSSA protein's role in this process is to ensure that another important protein called CSB is not broken down by exposure to UV rays.

Interactant

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