Sequence in raw or FASTA format:
UVSSA UV-stimulated scaffold protein A [Homo sapiens (human)]
|Entrez Gene ID||57654|
|Full Name||UV-stimulated scaffold protein A|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||The protein encoded by this gene appears to be involved in ubiquitination and dephosphorylation of RNA polymerase II subunits that stall after UV irradiation. The encoded protein interacts with several members of the nucleotide excision repair complex to help repair UV-induced DNA damage. Defects in this gene can cause UV-sensitive syndrome 3. [provided by RefSeq, May 2012].|
|Homo sapiens (human)||UVSSA||NP_065945.2|
|Pan troglodytes (chimpanzee)||UVSSA||XP_001174295.2|
|Macaca mulatta (Rhesus monkey)||LOC693853||XP_001082560.1|
|Canis lupus familiaris (dog)||UVSSA||XP_545930.3|
|Bos taurus (cattle)||KIAA1530||XP_002688500.3|
|Mus musculus (house mouse)||Uvssa||NP_001074570.1|
|Rattus norvegicus (Norway rat)||Uvssa||NP_001128030.1|
|Gallus gallus (chicken)||UVSSA||XP_420845.4|
|Danio rerio (zebrafish)||uvssa||XP_005157263.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||uvssa||NP_001107306.1|
|GO:0006283||transcription-coupled nucleotide-excision repair||IMP|
|GO:0009411||response to UV||IMP|
|GO:0000993||RNA polymerase II core binding||IDA|
|GO:0000993||RNA polymerase II core binding||IMP|
What is the normal function of the UVSSA gene?
The UVSSA gene provides instructions for making a protein that is involved in repairing DNA damaged by ultraviolet (UV) rays from the sun. The damage can block vital cell activities such as gene transcription, which is the first step in protein production. If left uncorrected, DNA damage accumulates, which causes cells to malfunction and can lead to cell death.
Cells have several mechanisms to correct DNA damage. The UVSSA protein is involved in one mechanism that repairs damaged DNA within active genes (those genes undergoing gene transcription). When DNA in active genes is damaged, the enzyme that carries out gene transcription (RNA polymerase) gets stuck, and the process stalls. Researchers think that the UVSSA protein helps remove RNA polymerase from the damaged site, so the DNA can be repaired. Part of the UVSSA protein's role in this process is to ensure that another important protein called CSB is not broken down by exposure to UV rays.
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