QSOX1 quiescin Q6 sulfhydryl oxidase 1 [Homo sapiens (human)]
| Gene Symbol | QSOX1 |
| Entrez Gene ID | 5768 |
| Full Name | quiescin Q6 sulfhydryl oxidase 1 |
| Synonyms | FLJ34858, Q6, QSCN6 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1q24 |
| Summary | This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]. |
| Disorder | MIM: 603120 |
| mRNA | NM_002826, 52493187 |
| Protein | NP_002817, 13325075 |
| Product | sulfhydryl oxidase 1 isoform a |
| RefSeq Status | REVIEWED |
| mRNA | NM_001004128, 52493188 |
| Protein | NP_001004128, 51873067 |
| Product | sulfhydryl oxidase 1 isoform b |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | QSOX1 | NP_002817.2 |
| Canis lupus familiaris (dog) | QSOX1 | XP_547419.2 |
| Bos taurus (cattle) | QSOX1 | NP_001095544.1 |
| Mus musculus (house mouse) | Qsox1 | NP_001020116.1 |
| Rattus norvegicus (Norway rat) | Qsox1 | NP_445883.1 |
| Gallus gallus (chicken) | QSOX1 | NP_989456.1 |
| Danio rerio (zebrafish) | si:dkey-39n1.2 | NP_001121836.1 |
| Drosophila melanogaster (fruit fly) | CG17843 | NP_650998.1 |
| Drosophila melanogaster (fruit fly) | CG6690 | NP_650997.1 |
| Drosophila melanogaster (fruit fly) | CG31413 | NP_732891.1 |
| Caenorhabditis elegans | F47B7.2 | NP_508652.1 |
| Caenorhabditis elegans | F35G2.1 | NP_502314.1 |
| Caenorhabditis elegans | T10H10.2 | NP_508419.1 |
| ID | Name | Evidence |
| GO:0006467 | protein thiol-disulfide exchange | IDA |
| GO:0006467 | protein thiol-disulfide exchange | IGI |
| GO:0045454 | cell redox homeostasis | IEA |
Component
| ID | Name | Evidence |
| GO:0000139 | Golgi membrane | IEA |
| GO:0005576 | extracellular region | IEA |
| GO:0005615 | extracellular space | IDA |
| GO:0005794 | Golgi apparatus | IEA |
| GO:0016020 | membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
| GO:0030173 | integral to Golgi membrane | IDA |
Function
| ID | Name | Evidence |
| GO:0016491 | oxidoreductase activity | IEA |
| GO:0016971 | flavin-linked sulfhydryl oxidase activity | IDA |
| GO:0016971 | flavin-linked sulfhydryl oxidase activity | IGI |
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