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SPTBN4 spectrin, beta, non-erythrocytic 4 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_020971 Homo sapiens spectrin, beta, non-erythrocytic 4 (SPTBN4), transcript variant sigma1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_025213 Homo sapiens spectrin, beta, non-erythrocytic 4 (SPTBN4), transcript variant sigma5, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006723306 PREDICTED: Homo sapiens spectrin, beta, non-erythrocytic 4 (SPTBN4), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol SPTBN4
Entrez Gene ID 57731
Full Name spectrin, beta, non-erythrocytic 4
Synonyms QV, SPNB4, SPTBN3
General protein information
Preferred Names
spectrin beta chain, non-erythrocytic 4
spectrin beta chain, non-erythrocytic 4
beta-IV spectrin
spectrin beta chain, brain 3
spectrin, non-erythroid beta chain 3
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

MIM: 606214

mRNA Protein Product Sequence Price Select
NM_020971, 115430236 NP_066022, 115430237 spectrin beta chain, non-erythrocytic 4 isoform sigma1 ORF Sequence $3500.00
NM_025213, 115430238 NP_079489, 115430239 spectrin beta chain, non-erythrocytic 4 isoform sigma5 ORF Sequence $700.00
XM_006723306, 578834709 XP_006723369, 578834710 spectrin beta chain, non-erythrocytic 4 isoform X1 ORF Sequence $3500.00
REACT_18266Axon guidance
REACT_18334NCAM signaling for neurite out-growth
REACT_22205L1CAM interactions
REACT_22266Interaction between L1 and Ankyrins
REACT_111045Developmental Biology
Homo sapiens (human)SPTBN4NP_066022.2
Macaca mulatta (Rhesus monkey)SPTBN4XP_002801295.1
Canis lupus familiaris (dog)SPTBN4XP_541613.2
Bos taurus (cattle)SPTBN4NP_001179839.1
Mus musculus (house mouse)Sptbn4NP_115999.2
Rattus norvegicus (Norway rat)Sptbn4NP_001094315.1
Xenopus (Silurana) tropicalis (western clawed frog)sptbn4XP_002938861.2
GO:0002028regulation of sodium ion transportISS
GO:0007016cytoskeletal anchoring at plasma membraneTAS
GO:0007411axon guidanceTAS
GO:0007605sensory perception of soundISS
GO:0007628adult walking behaviorISS
GO:0010459negative regulation of heart rateISS
GO:0016192vesicle-mediated transportTAS
GO:0019226transmission of nerve impulseISS
GO:0021952central nervous system projection neuron axonogenesisISS
GO:0033135regulation of peptidyl-serine phosphorylationISS
GO:0040018positive regulation of multicellular organism growthIEA
GO:0045162clustering of voltage-gated sodium channelsISS
GO:0051693actin filament cappingIEA
GO:0061337cardiac conductionISS
GO:0090002establishment of protein localization to plasma membraneISS
GO:0005886plasma membraneISS
GO:0005912adherens junctionISS
GO:0016363nuclear matrixIDA
GO:0016363nuclear matrixISS
GO:0016605PML bodyIDA
GO:0016605PML bodyISS
GO:0033268node of RanvierISS
GO:0033270paranode region of axonIEA
GO:0043025neuronal cell bodyISS
GO:0043194axon initial segmentISS
GO:0043203axon hillockISS
GO:0070852cell body fiberISS
GO:0003779actin bindingISS
GO:0003779actin bindingTAS
GO:0005200structural constituent of cytoskeletonTAS
GO:0005515protein bindingIPI
GO:0005543phospholipid bindingIEA
GO:0019902phosphatase bindingIPI
GO:0030506ankyrin bindingIDA
GO:0030506ankyrin bindingISS
GO:0030507spectrin bindingISS
GeneCards SPTBN4
UniProt Q9H254
Vega OTTHUMG00000182592
MIM 606214
Ensembl ENSG00000160460
HGNC 14896
HPRD 09372

GeneRIFs: Gene References Into Functions What's a GeneRIF?


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