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PTPRC protein tyrosine phosphatase, receptor type, C [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_002838 Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1, mRNA. Full Length $2398.50
ORF Sequence $1370.25
NM_080921 Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 2, mRNA. Full Length $1696.45
ORF Sequence $1201.20
NM_080923 Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 4, mRNA. Full Length $321.03
ORF Sequence $159.00


Gene Symbol PTPRC
Entrez Gene ID 5788
Full Name protein tyrosine phosphatase, receptor type, C
Synonyms B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q31-q32
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq].
Disorder

MIM: 151460

{Hepatitic C virus, susceptibility to}, 609532 (3); Severe combined
mRNA NM_002838, 115385975
Protein NP_002829, 18641347
Product receptor-type tyrosine-protein phosphatase C isoform 1 precursor
RefSeq Status REVIEWED
mRNA NM_080921, 115385973
Protein NP_563578, 18641362
Product receptor-type tyrosine-protein phosphatase C isoform 2 precursor
RefSeq Status REVIEWED
mRNA NM_080923, 115385974
Protein NP_563580, 18641366
Product receptor-type tyrosine-protein phosphatase C isoform 4
RefSeq Status REVIEWED
KEGG
hsa04660T cell receptor signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04514Cell adhesion molecules (CAMs)
hsa05340Primary immunodeficiency
Pathway Interaction Database
cxcr4_pathwayCXCR4-mediated signaling events
bcr_5pathwayBCR signaling pathway
tcr_pathwayTCR signaling in naive CD4+ T cells
cd8tcrpathwayTCR signaling in naive CD8+ T cells
WikiPathways
WP69T Cell Receptor Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP581EPO Receptor Signaling
Reactome
REACT_6900Signaling in Immune system
REACT_12526TCR signaling
REACT_19259Sema4D in semaphorin signaling
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_18266Axon guidance
REACT_19271Semaphorin interactions
Homo sapiens (human)PTPRCNP_002829.2
Pan troglodytes (chimpanzee)PTPRCXP_001142088.1
Canis lupus familiaris (dog)PTPRCXP_547374.2
Bos taurus (cattle)PTPRCXP_599431.3
Mus musculus (house mouse)PtprcNP_035340.2
Rattus norvegicus (Norway rat)PtprcXP_001062978.1
Gallus gallus (chicken)PTPRCNP_989748.1
Danio rerio (zebrafish)ptprcXP_687562.3
Process
IDNameEvidence
GO:0001915negative regulation of T cell mediated cytotoxicityISS
GO:0001960negative regulation of cytokine-mediated signaling pathwayISS
GO:0002378immunoglobulin biosynthetic processIMP
GO:0006469negative regulation of protein kinase activityIDA
GO:0006469negative regulation of protein kinase activityISS
GO:0006470protein dephosphorylationISS
GO:0007166cell surface receptor linked signaling pathwayTAS
GO:0007411axon guidanceTAS
GO:0016311dephosphorylationISS
GO:0030217T cell differentiationISS
GO:0030890positive regulation of B cell proliferationIMP
GO:0033261regulation of S phaseIMP
GO:0035335peptidyl-tyrosine dephosphorylationEXP
GO:0035335peptidyl-tyrosine dephosphorylationIDA
GO:0042100B cell proliferationISS
GO:0042102positive regulation of T cell proliferationISS
GO:0045860positive regulation of protein kinase activityNAS
GO:0050852T cell receptor signaling pathwayIDA
GO:0050852T cell receptor signaling pathwayTAS
GO:0050853B cell receptor signaling pathwayISS
GO:0050857positive regulation of antigen receptor-mediated signaling pathwayISS
GO:0051209release of sequestered calcium ion into cytosolISS
GO:0051607defense response to virusISS
GO:0051726regulation of cell cycleISS
Component
IDNameEvidence
GO:0005886plasma membraneEXP
GO:0005886plasma membraneTAS
GO:0005887integral to plasma membraneISS
GO:0005925focal adhesionISS
GO:0045121membrane raftIEA
Function
IDNameEvidence
GO:0004725protein tyrosine phosphatase activityEXP
GO:0004725protein tyrosine phosphatase activityIDA
GO:0005001transmembrane receptor protein tyrosine phosphatase activityTAS
GO:0005515protein bindingIPI
GO:0016787hydrolase activityIEA
GO:0019901protein kinase bindingIPI
GeneCards PTPRC
PDB 1YGU, 1YGR
UniProt P08575, Q0VAE8
MIM 151460
Ensembl ENSG00000081237
HGNC 9666
HPRD 01050

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