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Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 [Rattus norvegicus (Norway rat)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_021589 Rattus norvegicus neurotrophic tyrosine kinase, receptor, type 1 (Ntrk1), mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
XM_006232746 PREDICTED: Rattus norvegicus neurotrophic tyrosine kinase, receptor, type 1 (Ntrk1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol Ntrk1
Entrez Gene ID 59109
Full Name neurotrophic tyrosine kinase, receptor, type 1
Synonyms Trk
General protein information
Preferred Names
high affinity nerve growth factor receptor
Names
high affinity nerve growth factor receptor
trk
trk-A
p140-TrkA
TrkA neurotrophin receptor
trkA proto-oncogene receptor
tropomyosin-related kinase A
slow nerve growth factor receptor
NP_067600.1
Gene Type protein-coding
Organism Rattus norvegicus (Norway rat)
Genome

2

2q34

Summary a protooncogene; receptor that binds to nerve growth factor (NGF) [RGD, Feb 2006].
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_021589, 11024665 NP_067600, 11024666 high affinity nerve growth factor receptor precursor ORF Sequence $660.00
XM_006232746, 564337380 XP_006232808, 564337381 high affinity nerve growth factor receptor isoform X1 ORF Sequence $750.00
KEGG
rno04010MAPK signaling pathway
rno04210Apoptosis
rno05200Pathways in cancer
rno05216Thyroid cancer
rno04722Neurotrophin signaling pathway
rno04144Endocytosis
rno05202Transcriptional misregulation in cancer
rno04750Inflammatory mediator regulation of TRP channels
WikiPathways
WP358MAPK signaling pathway
Reactome
5658186Signal Transduction
5658681NGF-independant TRKA activation
5658239Signalling to RAS
5658332Signalling to p38 via RIT and RIN
5658327Frs2-mediated activation
5658565TRKA activation by NGF
5658784Signalling to STAT3
5658240Signalling to ERKs
5658198PLC-gamma1 signalling
5658329ARMS-mediated activation
5658766PI3K/AKT activation
5658200Signalling by NGF
5658199NGF signalling via TRKA from the plasma membrane
5658566Activation of TRKA receptors
5658674Retrograde neurotrophin signalling
5658328Prolonged ERK activation events
Homo sapiens (human)NTRK1NP_002520.2
Pan troglodytes (chimpanzee)NTRK1XP_003308563.1
Macaca mulatta (Rhesus monkey)NTRK1XP_001114243.2
Canis lupus familiaris (dog)NTRK1XP_851619.3
Bos taurus (cattle)NTRK1XP_002686012.2
Mus musculus (house mouse)Ntrk1NP_001028296.1
Rattus norvegicus (Norway rat)Ntrk1NP_067600.1
Gallus gallus (chicken)NTRK1NP_990709.1
Danio rerio (zebrafish)ntrk1XP_697246.5
Xenopus (Silurana) tropicalis (western clawed frog)ntrk1XP_002939035.1
Process
IDNameEvidence
GO:0006468protein phosphorylationISO
GO:0006468protein phosphorylationISS
GO:0007399nervous system developmentISO
GO:0007411axon guidanceIMP
GO:0007568agingIEP
GO:0007611learning or memoryIMP
GO:0008285negative regulation of cell proliferationISO
GO:0008285negative regulation of cell proliferationISO
GO:0008285negative regulation of cell proliferationISS
GO:0009314response to radiationIEP
GO:0010623developmental programmed cell deathIDA
GO:0010976positive regulation of neuron projection developmentISO
GO:0010976positive regulation of neuron projection developmentISO
GO:0010976positive regulation of neuron projection developmentISS
GO:0014823response to activityIDA
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0018108peptidyl-tyrosine phosphorylationIEA
GO:0018108peptidyl-tyrosine phosphorylationISO
GO:0018108peptidyl-tyrosine phosphorylationISS
GO:0019233sensory perception of painIMP
GO:0021553olfactory nerve developmentIEP
GO:0030183B cell differentiationIEA
GO:0030183B cell differentiationISO
GO:0031667response to nutrient levelsIDA
GO:0032320positive regulation of Ras GTPase activityISO
GO:0032320positive regulation of Ras GTPase activityISO
GO:0032320positive regulation of Ras GTPase activityISS
GO:0035094response to nicotineIDA
GO:0038180nerve growth factor signaling pathwayIDA
GO:0042490mechanoreceptor differentiationIEA
GO:0042490mechanoreceptor differentiationISO
GO:0042493response to drugIDA
GO:0043068positive regulation of programmed cell deathIDA
GO:0043524negative regulation of neuron apoptotic processIMP
GO:0043524negative regulation of neuron apoptotic processISO
GO:0045471response to ethanolIEP
GO:0045766positive regulation of angiogenesisIEA
GO:0045766positive regulation of angiogenesisISO
GO:0046579positive regulation of Ras protein signal transductionISO
GO:0046579positive regulation of Ras protein signal transductionISO
GO:0046579positive regulation of Ras protein signal transductionISS
GO:0046777protein autophosphorylationIDA
GO:0046777protein autophosphorylationISO
GO:0048011neurotrophin TRK receptor signaling pathwayISO
GO:0048011neurotrophin TRK receptor signaling pathwayISS
GO:0048485sympathetic nervous system developmentISO
GO:0048485sympathetic nervous system developmentISS
GO:0048678response to axon injuryIEP
GO:0050965detection of temperature stimulus involved in sensory perception of painIMP
GO:0050966detection of mechanical stimulus involved in sensory perception of painIMP
GO:0051092positive regulation of NF-kappaB transcription factor activityISO
GO:0051092positive regulation of NF-kappaB transcription factor activityISS
GO:0051599response to hydrostatic pressureIEP
GO:0051602response to electrical stimulusIDA
GO:0051968positive regulation of synaptic transmission, glutamatergicIMP
GO:0060009Sertoli cell developmentIMP
GO:0060385axonogenesis involved in innervationISO
GO:0060385axonogenesis involved in innervationISS
GO:0070374positive regulation of ERK1 and ERK2 cascadeISO
GO:0070374positive regulation of ERK1 and ERK2 cascadeISO
GO:0070374positive regulation of ERK1 and ERK2 cascadeISS
GO:0071316cellular response to nicotineIDA
GO:0071363cellular response to growth factor stimulusIDA
GO:1901215negative regulation of neuron deathIDA
GO:1990090cellular response to nerve growth factor stimulusIDA
Component
IDNameEvidence
GO:0000139Golgi membraneTAS
GO:0005737cytoplasmISO
GO:0005769early endosomeIDA
GO:0005770late endosomeIDA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneISO
GO:0005887integral component of plasma membraneISS
GO:0009986cell surfaceIDA
GO:0030424axonIDA
GO:0030425dendriteIDA
GO:0031410cytoplasmic vesicleIDA
GO:0031901early endosome membraneIEA
GO:0031902late endosome membraneIEA
GO:0043025neuronal cell bodyIDA
GO:0043234protein complexIDA
GO:0043235receptor complexISO
Function
IDNameEvidence
GO:0004713protein tyrosine kinase activityIDA
GO:0004714transmembrane receptor protein tyrosine kinase activityISO
GO:0004714transmembrane receptor protein tyrosine kinase activityISS
GO:0005166neurotrophin p75 receptor bindingIPI
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0010465nerve growth factor receptor activityISO
GO:0010465nerve growth factor receptor activityISS
GO:0042803protein homodimerization activityISO
GO:0042803protein homodimerization activityISS
GO:0046875ephrin receptor bindingIPI
GO:0048406nerve growth factor bindingIDA
GO:0048406nerve growth factor bindingISO
GO:0048406nerve growth factor bindingISO
GO:0048406nerve growth factor bindingISS
GeneCards Ntrk1
UniProt P35739
RGD 620144
Ensembl ENSRNOG00000013953

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the NTRK1 gene?

The NTRK1 gene provides instructions for making a protein that is essential for the development and survival of nerve cells (neurons), especially those that transmit information about sensations such as pain, temperature, and touch (sensory neurons). The NTRK1 protein is found on the surface of cells, particularly sensory neurons. It acts as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions. This process is called phosphorylation. The NTRK1 protein is turned on (activated) when another protein called nerve growth factor beta (NGFβ) attaches (binds) to it and signals the NTRK1 protein to phosphorylate itself (autophosphorylation). Then, the activated NTRK1 protein phosphorylates other proteins; this process is needed to transmit signals for cell growth and survival.

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