Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 [Rattus norvegicus (Norway rat)]
| Gene Symbol | Ntrk1 |
| Entrez Gene ID | 59109 |
| Full Name | neurotrophic tyrosine kinase, receptor, type 1 |
| Synonyms | Trk |
| Gene Type | protein-coding |
| Organism | Rattus norvegicus (Norway rat) |
| Genome |
2 2q34 |
| Summary | a protooncogene; receptor that binds to nerve growth factor (NGF) [RGD]. |
| Disorder | MIM: |
| mRNA | NM_021589, 11024665 |
| Protein | NP_067600, 11024666 |
| Product | high affinity nerve growth factor receptor precursor |
| RefSeq Status | PROVISIONAL |
| rno04722 | Neurotrophin signaling pathway |
| rno04144 | Endocytosis |
| rno04010 | MAPK signaling pathway |
| rno05216 | Thyroid cancer |
| rno05200 | Pathways in cancer |
| rno04210 | Apoptosis |
WikiPathways
| WP358 | MAPK signaling pathway |
Reactome
| 1235671 | Frs2-mediated activation |
| 1235558 | NGF signalling via TRKA from the plasma membrane |
| 1235876 | Activation of TRKA receptors |
| 1235943 | Retrograde neurotrophin signalling |
| 1235666 | Signalling to p38 via RIT and RIN |
| 1235672 | Prolonged ERK activation events |
| 1236051 | Signalling to STAT3 |
| 1235673 | ARMS-mediated activation |
| 1235574 | Signalling to RAS |
| 1235948 | NGF-independant TRKA activation |
| 1235575 | Signalling to ERKs |
| 1235557 | PLC-gamma1 signalling |
| 1236039 | PI3K/AKT signalling |
| 1235559 | Signalling by NGF |
| 1235875 | TRKA activation by NGF |
| Homo sapiens (human) | NTRK1 | NP_002520.2 |
| Pan troglodytes (chimpanzee) | NTRK1 | XP_001145942.1 |
| Canis lupus familiaris (dog) | NTRK1 | XP_547525.2 |
| Bos taurus (cattle) | NTRK1 | XP_613650.3 |
| Mus musculus (house mouse) | Ntrk1 | XP_283871.1 |
| Rattus norvegicus (Norway rat) | Ntrk1 | NP_067600.1 |
| Gallus gallus (chicken) | NTRK1 | NP_990709.1 |
| Danio rerio (zebrafish) | ntrk1 | XP_697246.4 |
| ID | Name | Evidence |
| GO:0006468 | protein phosphorylation | ISO |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IEA |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | ISO |
| GO:0007190 | activation of adenylate cyclase activity | ISO |
| GO:0007264 | small GTPase mediated signal transduction | ISO |
| GO:0007265 | Ras protein signal transduction | ISO |
| GO:0007275 | multicellular organismal development | IEA |
| GO:0007399 | nervous system development | IEA |
| GO:0007399 | nervous system development | ISO |
| GO:0030154 | cell differentiation | IEA |
| GO:0030183 | B cell differentiation | IEA |
| GO:0030183 | B cell differentiation | ISO |
| GO:0042490 | mechanoreceptor differentiation | IEA |
| GO:0042490 | mechanoreceptor differentiation | ISO |
| GO:0043524 | negative regulation of neuron apoptosis | IEA |
| GO:0043524 | negative regulation of neuron apoptosis | ISO |
| GO:0046777 | protein autophosphorylation | IDA |
| GO:0071363 | cellular response to growth factor stimulus | IDA |
Component
| ID | Name | Evidence |
| GO:0000139 | Golgi membrane | EXP |
| GO:0005737 | cytoplasm | IEA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005768 | endosome | ISO |
| GO:0005886 | plasma membrane | EXP |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | TAS |
| GO:0005887 | integral to plasma membrane | IEA |
| GO:0009986 | cell surface | IDA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0004713 | protein tyrosine kinase activity | IDA |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IEA |
| GO:0005030 | neurotrophin receptor activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0016740 | transferase activity | IEA |
| GeneCards | Ntrk1 |
| UniProt | P35739 |
| RGD | 620144 |
| Ensembl | ENSRNOG00000013953 |
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