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OPN1LW opsin 1 (cone pigments), long-wave-sensitive [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_020061 Homo sapiens opsin 1 (cone pigments), long-wave-sensitive (OPN1LW), mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol OPN1LW
Entrez Gene ID 5956
Full Name opsin 1 (cone pigments), long-wave-sensitive
Synonyms CBBM, CBP, COD5, RCP, ROP
General protein information
Preferred Names
long-wave-sensitive opsin 1
long-wave-sensitive opsin 1
red-sensitive opsin
cone dystrophy 5 (X-linked)
red cone photoreceptor pigment
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. [provided by RefSeq, Jul 2008].

MIM: 300822

Colorblindness, protan, 303900 (3); Blue cone monochromacy, 303700

mRNA Protein Product Sequence Price Select
NM_020061, 539848520 NP_064445, 539848521 long-wave-sensitive opsin 1 ORF Sequence $400.00
WP455GPCRs, Class A Rhodopsin-like
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14797Signaling by GPCR
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
REACT_160102Diseases associated with visual transduction
REACT_160083The retinoid cycle in cones (daylight vision)
REACT_160125Visual phototransduction
REACT_160130Retinoid cycle disease events
Homo sapiens (human)OPN1LWNP_064445.2
Pan troglodytes (chimpanzee)OPN1LWXP_003317827.1
Canis lupus familiaris (dog)OPN1LWNP_001184001.1
Bos taurus (cattle)OPN1LWNP_776991.1
Mus musculus (house mouse)Opn1mwNP_032132.1
Rattus norvegicus (Norway rat)Opn1mwNP_446000.1
Gallus gallus (chicken)OPN1LWNP_990771.1
Danio rerio (zebrafish)opn1lw2NP_001002443.1
Danio rerio (zebrafish)opn1lw1NP_571250.1
Xenopus (Silurana) tropicalis (western clawed frog)opn1lwNP_001096331.1
GO:0001523retinoid metabolic processTAS
GO:0007165signal transductionTAS
GO:0007186G-protein coupled receptor signaling pathwayIEA
GO:0007601visual perceptionIEA
GO:0007603phototransduction, visible lightTAS
GO:0018298protein-chromophore linkageIEA
GO:0032467positive regulation of cytokinesisIMP
GO:0005887integral component of plasma membraneTAS
GO:0042622photoreceptor outer segment membraneTAS
GO:0004930G-protein coupled receptor activityIEA
GO:0009881photoreceptor activityIEA
GeneCards OPN1LW
Vega OTTHUMG00000034295
MIM 300822
Ensembl ENSG00000102076
HGNC 9936
HPRD 02366

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the OPN1LW gene?

The OPN1LW gene provides instructions for making a protein that is essential for normal color vision. This gene is active in the retina, a light-sensitive tissue at the back of the eye. The retina contains two types of light receptor cells called rods and cones. Rods are responsible for vision in low light. Cones provide vision in bright light, including color vision. Three types of cones each contain a special pigment (a photopigment) that is most sensitive to a particular wavelength of light.

The OPN1LW gene produces a photopigment that is more sensitive to light at the red end of the visible spectrum. Cones with this pigment are usually called long-wavelength-sensitive or L cones. In response to light at long wavelengths, the photopigment triggers a series of chemical reactions within an L cone cell. These reactions ultimately alter the cell's electrical charge, generating a signal that is transmitted to the brain. The brain combines input from all three types of cones to produce normal color vision.

The long-wavelength-sensitive pigment gene (OPN1LW) and the middle-wavelength-sensitive pigment gene (OPN1MW) are very similar and are located close together on the X chromosome. Most people have one copy of the OPN1LW gene and one or more copies of the OPN1MW gene. A nearby region of DNA, known as the locus control region (LCR), regulates the activity of these genes. Only the two pigment genes nearest the LCR are active in the retina.


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