Sequence in raw or FASTA format:
OPN1LW opsin 1 (cone pigments), long-wave-sensitive [Homo sapiens (human)]
|Entrez Gene ID||5956|
|Full Name||opsin 1 (cone pigments), long-wave-sensitive|
|Synonyms||CBBM, CBP, COD5, RCP, ROP|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. [provided by RefSeq, Jul 2008].|
Colorblindness, protan, 303900 (3); Blue cone monochromacy, 303700
|WP455||GPCRs, Class A Rhodopsin-like|
|REACT_19184||GPCR downstream signaling|
|REACT_19231||G alpha (i) signalling events|
|REACT_14828||Class A/1 (Rhodopsin-like receptors)|
|REACT_14797||Signaling by GPCR|
|REACT_21340||GPCR ligand binding|
|REACT_160102||Diseases associated with visual transduction|
|REACT_160083||The retinoid cycle in cones (daylight vision)|
|REACT_160130||Retinoid cycle disease events|
|Homo sapiens (human)||OPN1LW||NP_064445.2|
|Pan troglodytes (chimpanzee)||OPN1LW||XP_003317827.1|
|Canis lupus familiaris (dog)||OPN1LW||NP_001184001.1|
|Bos taurus (cattle)||OPN1LW||NP_776991.1|
|Mus musculus (house mouse)||Opn1mw||NP_032132.1|
|Rattus norvegicus (Norway rat)||Opn1mw||NP_446000.1|
|Gallus gallus (chicken)||OPN1LW||NP_990771.1|
|Danio rerio (zebrafish)||opn1lw2||NP_001002443.1|
|Danio rerio (zebrafish)||opn1lw1||NP_571250.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||opn1lw||NP_001096331.1|
|GO:0001523||retinoid metabolic process||TAS|
|GO:0007186||G-protein coupled receptor signaling pathway||IEA|
|GO:0007603||phototransduction, visible light||TAS|
|GO:0032467||positive regulation of cytokinesis||IMP|
|GO:0005887||integral component of plasma membrane||TAS|
|GO:0042622||photoreceptor outer segment membrane||TAS|
|GO:0004930||G-protein coupled receptor activity||IEA|
What is the normal function of the OPN1LW gene?
The OPN1LW gene provides instructions for making a protein that is essential for normal color vision. This gene is active in the retina, a light-sensitive tissue at the back of the eye. The retina contains two types of light receptor cells called rods and cones. Rods are responsible for vision in low light. Cones provide vision in bright light, including color vision. Three types of cones each contain a special pigment (a photopigment) that is most sensitive to a particular wavelength of light.
The OPN1LW gene produces a photopigment that is more sensitive to light at the red end of the visible spectrum. Cones with this pigment are usually called long-wavelength-sensitive or L cones. In response to light at long wavelengths, the photopigment triggers a series of chemical reactions within an L cone cell. These reactions ultimately alter the cell's electrical charge, generating a signal that is transmitted to the brain. The brain combines input from all three types of cones to produce normal color vision.
The long-wavelength-sensitive pigment gene (OPN1LW) and the middle-wavelength-sensitive pigment gene (OPN1MW) are very similar and are located close together on the X chromosome. Most people have one copy of the OPN1LW gene and one or more copies of the OPN1MW gene. A nearby region of DNA, known as the locus control region (LCR), regulates the activity of these genes. Only the two pigment genes nearest the LCR are active in the retina.
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