Sequence in raw or FASTA format:
RIT1 Ras-like without CAAX 1 [Homo sapiens (human)]
| Gene Symbol | RIT1 |
| Entrez Gene ID | 6016 |
| Full Name | Ras-like without CAAX 1 |
| Synonyms | MGC125864, MGC125865, RIBB, RIT, ROC1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1q22 |
| Summary | RIT belongs to the RAS (HRAS; MIM 190020) subfamily of small GTPases (Hynds et al., 2003 [PubMed 12668729]).[supplied by OMIM]. |
| Disorder | MIM: 609591 |
| mRNA | NM_006912, 93004097 |
| Protein | NP_008843, 5902050 |
| Product | GTP-binding protein Rit1 |
| RefSeq Status | VALIDATED |
| trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
Reactome
| REACT_12056 | NGF signalling via TRKA from the plasma membrane |
| REACT_11061 | Signalling by NGF |
| REACT_12058 | Signalling to ERKs |
| REACT_12077 | Signalling to p38 via RIT and RIN |
| Homo sapiens (human) | RIT1 | NP_008843.1 |
| Pan troglodytes (chimpanzee) | RIT1 | XP_001162309.1 |
| Canis lupus familiaris (dog) | RIT1 | XP_537249.2 |
| Bos taurus (cattle) | RIT1 | NP_001091547.1 |
| Mus musculus (house mouse) | Rit1 | NP_033095.1 |
| Rattus norvegicus (Norway rat) | Rit1 | XP_574975.1 |
| Gallus gallus (chicken) | RIT1 | NP_001026498.1 |
| Danio rerio (zebrafish) | rit1 | NP_001122253.1 |
| ID | Name | Evidence |
| GO:0007165 | signal transduction | IEA |
| GO:0007264 | small GTPase mediated signal transduction | EXP |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS |
Component
| ID | Name | Evidence |
| GO:0005622 | intracellular | IEA |
| GO:0005886 | plasma membrane | TAS |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0003924 | GTPase activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0005516 | calmodulin binding | TAS |
| GO:0005525 | GTP binding | IEA |
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