BCL6 B-cell CLL/lymphoma 6 [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	BCL6
Entrez Gene ID	604
Full Name	B-cell CLL/lymphoma 6
Synonyms	BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:3 Map Location:3q27
Summary	The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq].
Disorder	MIM: 109565 Lymphoma, B-cell (2)

mRNA	NM_001130845, 195927001
Protein	NP_001124317, 195927002
Product	B-cell lymphoma 6 protein isoform 1
RefSeq Status	REVIEWED
mRNA	NM_001134738, 197927146
Protein	NP_001128210, 197927147
Product	B-cell lymphoma 6 protein isoform 2
RefSeq Status	REVIEWED
mRNA	NM_001706, 299115782
Protein	NP_001697, 21040324
Product	B-cell lymphoma 6 protein isoform 1
RefSeq Status	REVIEWED

WikiPathways

WP23	B Cell Receptor Signaling Pathway

Pathway Interaction Database

il4_2pathway	IL4-mediated signaling events
p53downstreampathway	Direct p53 effectors
foxopathway	FoxO family signaling
hdac_classii_pathway	Signaling events mediated by HDAC Class II

Homo sapiens (human)	BCL6	NP_001124317.1
Pan troglodytes (chimpanzee)	BCL6	XP_001158812.1
Canis lupus familiaris (dog)	BCL6	XP_545248.2
Bos taurus (cattle)	BCL6	XP_870784.1
Mus musculus (house mouse)	Bcl6	NP_033874.1
Rattus norvegicus (Norway rat)	Bcl6	XP_221333.1
Gallus gallus (chicken)	BCL6	NP_001012948.1
Danio rerio (zebrafish)	bcl6a	NP_957028.1

Process

ID	Name	Evidence
GO:0000060	protein import into nucleus, translocation	IGI
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0000902	cell morphogenesis	IEA
GO:0001953	negative regulation of cell-matrix adhesion	IEA
GO:0002634	regulation of germinal center formation	NAS
GO:0002829	negative regulation of type 2 immune response	IEA
GO:0002903	negative regulation of B cell apoptosis	NAS
GO:0006351	transcription, DNA-dependent	IMP
GO:0006355	regulation of transcription, DNA-dependent	IEA
GO:0006974	response to DNA damage stimulus	IDA
GO:0007283	spermatogenesis	IEA
GO:0008104	protein localization	IEA
GO:0008285	negative regulation of cell proliferation	IEA
GO:0030036	actin cytoskeleton organization	IEA
GO:0030183	B cell differentiation	IEA
GO:0030308	negative regulation of cell growth	IDA
GO:0030890	positive regulation of B cell proliferation	IEA
GO:0032319	regulation of Rho GTPase activity	IEA
GO:0032764	negative regulation of mast cell cytokine production	IEA
GO:0035024	negative regulation of Rho protein signal transduction	IEA
GO:0043065	positive regulation of apoptosis	IDA
GO:0043066	negative regulation of apoptosis	IEA
GO:0043380	regulation of memory T cell differentiation	IEA
GO:0045596	negative regulation of cell differentiation	IEA
GO:0045629	negative regulation of T-helper 2 cell differentiation	IEA
GO:0045749	negative regulation of S phase of mitotic cell cycle	NAS
GO:0048294	negative regulation of isotype switching to IgE isotypes	IEA
GO:0048821	erythrocyte development	IEA
GO:0050727	regulation of inflammatory response	IEA
GO:0050776	regulation of immune response	NAS
GO:0051272	positive regulation of cellular component movement	IEA

Component

ID	Name	Evidence
GO:0005622	intracellular	IEA
GO:0005634	nucleus	IDA
GO:0005657	replication fork	IDA
GO:0005730	nucleolus	IDA

Function

ID	Name	Evidence
GO:0003682	chromatin binding	IDA
GO:0003700	sequence-specific DNA binding transcription factor activity	IMP
GO:0005515	protein binding	IPI
GO:0008270	zinc ion binding	IEA
GO:0031490	chromatin DNA binding	IEA
GO:0043565	sequence-specific DNA binding	IDA
GO:0046872	metal ion binding	IEA

GeneCards	BCL6
PDB	1R2B, 3BIM, 3LBZ, 1R28, 2EN2, 1R29, 2YRM, 2EOS, 3E4U
UniProt	P41182, B5B0A5, B8PSA7
MIM	109565
Ensembl	ENSG00000113916
HGNC	1001
HPRD	00180

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RefSeq Accession	Definition	Sequence	Price	Select
NM_001130845	Homo sapiens B-cell CLL/lymphoma 6 (BCL6), transcript variant 2, mRNA.	Full Length	$1281.70
NM_001130845		ORF Sequence	$615.09
NM_001134738	Homo sapiens B-cell CLL/lymphoma 6 (BCL6), transcript variant 3, mRNA.	Full Length	$1080.10
NM_001134738		ORF Sequence	$566.37
NM_001706	Homo sapiens B-cell CLL/lymphoma 6 (BCL6), transcript variant 1, mRNA.	Full Length	$1251.25
NM_001706		ORF Sequence	$615.09