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HPSE2 heparanase 2 (inactive) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu24514 NM_001166246 Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $269.00
OHu24540 NM_001166245 Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $269.00
OHu24543 NM_021828 Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $269.00
OHu24558 NM_001166244 Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $269.00
OHu44459 XM_006717937 PREDICTED: Homo sapiens heparanase 2 (HPSE2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $269.00
OHu24514C NM_001166246 Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 4, mRNA. Customized vector On-demand 7-9 $269.00
OHu24540C NM_001166245 Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu24543C NM_021828 Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu24558C NM_001166244 Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu44459C XM_006717937 PREDICTED: Homo sapiens heparanase 2 (HPSE2), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol HPSE2
Entrez Gene ID 60495
Full Name heparanase 2 (inactive)
Synonyms HPA2, HPR2, UFS, UFS1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q23-q24

Summary This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
Disorder

MIM: 613469

Urofacial syndrome, 236730 (3)

mRNA Protein Product Sequence Price Select
NM_001166244, 261878502 NP_001159716, 261878503 inactive heparanase-2 isoform 2 ORF Sequence $550.00
NM_001166245, 261878504 NP_001159717, 261878505 inactive heparanase-2 isoform 3 ORF Sequence $550.00
NM_001166246, 261878506 NP_001159718, 261878507 inactive heparanase-2 isoform 4 ORF Sequence $550.00
NM_021828, 261878500 NP_068600, 261878501 inactive heparanase-2 isoform 1 ORF Sequence $700.00
XM_006717937, 578819679 XP_006718000, 578819680 inactive heparanase-2 isoform X1 ORF Sequence $550.00
KEGG
hsa00531Glycosaminoglycan degradation
hsa_M00078Heparan sulfate degradation
hsa05205Proteoglycans in cancer
Reactome
REACT_474Metabolism of carbohydrates
REACT_111217Metabolism
REACT_147749MPS IIID - Sanfilippo syndrome D
REACT_147825MPS IV - Morquio syndrome A
REACT_147719MPS VI - Maroteaux-Lamy syndrome
REACT_147753MPS IIIA - Sanfilippo syndrome A
REACT_147739MPS IX - Natowicz syndrome
REACT_147860MPS IIIC - Sanfilippo syndrome C
REACT_147853Mucopolysaccharidoses
REACT_147734MPS II - Hunter syndrome
REACT_147788MPS IIIB - Sanfilippo syndrome B
REACT_147759MPS VII - Sly syndrome
REACT_147798MPS IV - Morquio syndrome B
REACT_147857MPS I - Hurler syndrome
REACT_116125Disease
REACT_121315Glycosaminoglycan metabolism
REACT_121314Heparan sulfate/heparin (HS-GAG) metabolism
REACT_120752HS-GAG degradation
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)HPSE2NP_068600.4
Pan troglodytes (chimpanzee)HPSE2XP_001166372.1
Canis lupus familiaris (dog)HPSE2XP_850311.1
Bos taurus (cattle)HPSE2XP_005225719.1
Mus musculus (house mouse)Hpse2NP_001074726.1
Rattus norvegicus (Norway rat)Hpse2NP_001129234.1
Gallus gallus (chicken)HPSE2XP_421704.2
Danio rerio (zebrafish)hpse2XP_691045.2
Xenopus (Silurana) tropicalis (western clawed frog)hpse2XP_002937229.1
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processTAS
GO:0006027glycosaminoglycan catabolic processTAS
GO:0008150biological_processND
GO:0030203glycosaminoglycan metabolic processTAS
GO:0044281small molecule metabolic processTAS
Component
IDNameEvidence
GO:0005578proteinaceous extracellular matrixIDA
GO:0005622intracellularTAS
GO:0005886plasma membraneTAS
Function
IDNameEvidence
GO:0030305heparanase activityIDA
GO:0030305heparanase activityTAS
GO:0043395heparan sulfate proteoglycan bindingIDA
GeneCards HPSE2
UniProt Q8WWQ2, Q2M1H9
MIM 613469
HGNC 18374
HPRD 13669

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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