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SCN9A sodium channel, voltage-gated, type IX, alpha subunit [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002977 Homo sapiens sodium channel, voltage-gated, type IX, alpha subunit (SCN9A), mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_005246757 PREDICTED: Homo sapiens sodium channel, voltage-gated, type IX, alpha subunit (SCN9A), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $2699.00 30

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Gene Symbol SCN9A
Entrez Gene ID 6335
Full Name sodium channel, voltage-gated, type IX, alpha subunit
Synonyms ETHA, FEB3B, GEFSP7, NE-NA, NENA, Nav1.7, PN1, SFNP
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009].

MIM: 603415

Erythermalgia, primary, 133020 (3); Insensitivity to pain,

mRNA Protein Product Sequence Price Select
NM_002977, 256017191 NP_002968, 4506813 sodium channel protein type 9 subunit alpha ORF Sequence $2500.00
XM_005246757, 530370759 XP_005246814, 530370760 sodium channel protein type 9 subunit alpha isoform X1 ORF Sequence $2500.00
REACT_18266Axon guidance
REACT_22205L1CAM interactions
REACT_22266Interaction between L1 and Ankyrins
REACT_111045Developmental Biology
Homo sapiens (human)SCN9ANP_002968.1
Pan troglodytes (chimpanzee)SCN9AXP_003309333.2
Macaca mulatta (Rhesus monkey)SCN9AXP_001101662.2
Canis lupus familiaris (dog)SCN9AXP_005640317.1
Bos taurus (cattle)SCN9ANP_001104257.1
Mus musculus (house mouse)Scn9aNP_061340.2
Rattus norvegicus (Norway rat)Scn9aNP_579823.1
Gallus gallus (chicken)SCN9AXP_004942840.1
Xenopus (Silurana) tropicalis (western clawed frog)scn2aXP_002939316.2
GO:0006814sodium ion transportTAS
GO:0006954inflammatory responseIEA
GO:0009636response to toxic substanceIEA
GO:0009791post-embryonic developmentIEA
GO:0019228neuronal action potentialIBA
GO:0034765regulation of ion transmembrane transportIEA
GO:0035725sodium ion transmembrane transportIBA
GO:0048266behavioral response to painIEA
GO:0086010membrane depolarization during action potentialIBA
GO:0001518voltage-gated sodium channel complexIEA
GO:0005886plasma membraneIBA
GO:0005248voltage-gated sodium channel activityIBA
GO:0031402sodium ion bindingIEA
GeneCards SCN9A
UniProt Q15858
Vega OTTHUMG00000154044
MIM 603415
Ensembl ENSG00000169432
HGNC 10597
HPRD 04565

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SCN9A gene?

The SCN9A gene belongs to a family of genes that provide instructions for making sodium channels. These channels, which transport positively charged sodium atoms (sodium ions) into cells, play a key role in a cell's ability to generate and transmit electrical signals.

The SCN9A gene provides instructions for making one part (the alpha subunit) of a sodium channel called NaV1.7. NaV1.7 sodium channels are found in nerve cells called nociceptors that transmit pain signals. Nociceptors are part of the peripheral nervous system, which connects the brain and spinal cord to cells that detect sensations such as touch, smell, and pain. Nociceptors are primarily involved in transmitting pain signals. The centers of nociceptors, known as the cell bodies, are located in a part of the spinal cord called the dorsal root ganglion. Fibers called axons extend from the cell bodies, reaching throughout the body to receive sensory information. Axons transmit the information back to the dorsal root ganglion, which then sends it to the brain. NaV1.7 sodium channels are also found in olfactory sensory neurons, which are nerve cells in the nasal cavity that transmit smell-related signals to the brain.


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