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SFTPB surfactant protein B [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000542 Homo sapiens surfactant protein B (SFTPB), transcript variant 1, mRNA. ORF Sequence $342.78
Peptide Services
Antibody Services
Protein Services
NM_198843 Homo sapiens surfactant protein B (SFTPB), transcript variant 2, mRNA. ORF Sequence $342.78
Peptide Services
Antibody Services
Protein Services


Gene Symbol SFTPB
Entrez Gene ID 6439
Full Name surfactant protein B
Synonyms PSP-B, SFTB3, SFTP3, SMDP1, SP-B
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p12-p11.2

Summary This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010].
Disorder

MIM: 178640

Surfactant metabolism dysfunction, pulmonary, 1, 265120 (3)

mRNA Protein Product Sequence Price Select
NM_000542, 288856298 NP_000533, 288856299 pulmonary surfactant-associated protein B precursor Full Length $1288.35
ORF Sequence $342.78
NM_198843, 288856296 NP_942140, 288856297 pulmonary surfactant-associated protein B precursor Full Length $827.66
ORF Sequence $342.78
Homo sapiens (human)SFTPBNP_000533.3
Pan troglodytes (chimpanzee)SFTPBXP_001168379.2
Macaca mulatta (Rhesus monkey)SFTPBXP_001089841.1
Canis lupus familiaris (dog)SFTPBXP_003432215.2
Bos taurus (cattle)SFTPBNP_001068779.1
Mus musculus (house mouse)SftpbNP_680088.1
Rattus norvegicus (Norway rat)SftpbNP_620197.1
GeneCards SFTPB
PDB 1SSZ, 1RG3, 1DFW, 1RG4, 2JOU, 2DWF, 1KMR
UniProt P07988, D6W5L6
MIM 178640
Ensembl ENSG00000168878
HGNC 10801
HPRD 01523

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
pulmonary surfactant-associated protein B
Names
pulmonary surfactant-associated protein B
6 kDa protein
18 kDa pulmonary-surfactant protein
pulmonary surfactant-associated proteolipid SPL(Phe)

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