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Sequence in raw or FASTA format:

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WNK4 WNK lysine deficient protein kinase 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_032387 Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005257595 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005257596 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005257597 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005257598 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006722020 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006722021 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006722022 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $899.00 20

*Business Day

Related Services

Gene Symbol WNK4
Entrez Gene ID 65266
Full Name WNK lysine deficient protein kinase 4
Synonyms PHA2B, PRKWNK4
General protein information
Preferred Names
serine/threonine-protein kinase WNK4
Names
serine/threonine-protein kinase WNK4
protein kinase with no lysine 4
protein kinase lysine-deficient 4
NP_115763.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q21-q22

Summary This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009].
Disorder

MIM: 601844

Pseudohypoaldosteronism type II, 145260 (3)

mRNA Protein Product Sequence Price Select
NM_032387, 260166636 NP_115763, 34365793 serine/threonine-protein kinase WNK4 ORF Sequence $1500.00
XM_005257595, 578831263 XP_005257652, 530412705 serine/threonine-protein kinase WNK4 isoform X1 ORF Sequence $1500.00
XM_005257596, 530412706 XP_005257653, 530412707 serine/threonine-protein kinase WNK4 isoform X2 ORF Sequence $1500.00
XM_005257597, 578831264 XP_005257654, 530412709 serine/threonine-protein kinase WNK4 isoform X3 ORF Sequence $1500.00
XM_005257598, 578831267 XP_005257655, 530412711 serine/threonine-protein kinase WNK4 isoform X4 ORF Sequence $750.00
XM_006722020, 578831265 XP_006722083, 578831266 serine/threonine-protein kinase WNK4 isoform X5 ORF Sequence $1500.00
XM_006722021, 578831268 XP_006722084, 578831269 serine/threonine-protein kinase WNK4 isoform X6 ORF Sequence $750.00
XM_006722022, 578831270 XP_006722085, 578831271 serine/threonine-protein kinase WNK4 isoform X7 ORF Sequence $750.00
Reactome
REACT_15518Transmembrane transport of small molecules
REACT_25300Ion channel transport
REACT_160189Stimuli-sensing channels
Homo sapiens (human)WNK4NP_115763.2
Pan troglodytes (chimpanzee)WNK4XP_003315535.1
Macaca mulatta (Rhesus monkey)LOC707820XP_002808177.1
Canis lupus familiaris (dog)WNK4XP_548082.3
Bos taurus (cattle)WNK4XP_003587489.1
Mus musculus (house mouse)Wnk4NP_783569.1
Rattus norvegicus (Norway rat)Wnk4NP_783169.2
Gallus gallus (chicken)LOC777580XP_003642875.2
Process
IDNameEvidence
GO:0006468protein phosphorylationISS
GO:0006811ion transportISS
GO:0006821chloride transportIEA
GO:0008104protein localizationIEA
GO:0035556intracellular signal transductionISS
GO:0050794regulation of cellular processISS
GO:0050801ion homeostasisIMP
GO:0070294renal sodium ion absorptionIMP
GO:0072156distal tubule morphogenesisIMP
GO:0090188negative regulation of pancreatic juice secretionIEA
Component
IDNameEvidence
GO:0005737cytoplasmIEA
GO:0005923tight junctionISS
Function
IDNameEvidence
GO:0004674protein serine/threonine kinase activityISS
GO:0005515protein bindingIPI
GO:0005524ATP bindingISS
GO:0019869chloride channel inhibitor activityIDA
GeneCards WNK4
UniProt Q96J92
Vega OTTHUMG00000180650
MIM 601844
Ensembl ENSG00000126562
HGNC 14544
HPRD 03505

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the WNK4 gene?

The WNK4 gene provides instructions for making a protein that plays a role in blood pressure regulation by helping control the amount of sodium and potassium in the body. The WNK4 protein acts as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions.

The WNK4 protein regulates channels in the cell membrane that control the transport of sodium or potassium into and out of cells, which occurs primarily in the kidneys. Sodium channels help transport sodium into specialized cells of the kidney, from which it is transferred to the blood. This transfer helps keep sodium in the body through a process called reabsorption. Potassium channels handle excess potassium that has been transferred from the blood into the kidney cells. The channels transport the potassium out of the cells in a process called secretion, so that it can be removed from the body in the urine. The WNK4 protein blocks (inhibits) sodium reabsorption and potassium secretion.

Interactant

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