PTPN20A protein tyrosine phosphatase, non-receptor type 20A [Homo sapiens (human)]
| Gene Symbol | PTPN20A |
| Entrez Gene ID | 653129 |
| Full Name | protein tyrosine phosphatase, non-receptor type 20A |
| Synonyms | CT126, MGC142033, PTPN20B, bA142I17.1, hPTPN20 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
10 10q11.22 |
| Summary | The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes and several are mutated in human diseases. Chromosome 10q contains a segmental duplication resulting in multiple copies of the protein tyrosine phosphatase, non-receptor type 20 gene. The two nearly identical copies are designated as PTPN20A and PTPN20B. A third copy is only partially duplicated and contains a pseudogene, designated as PTPN20C. This gene encodes the more centromeric copy, PTPN20A. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]. |
| Disorder | MIM: 610630 |
| mRNA | NM_001042390, 109138560 |
| Protein | NP_001035849, 109138561 |
| Product | tyrosine-protein phosphatase non-receptor type 20 isoform 3 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001042391, 109138562 |
| Protein | NP_001035850, 109138563 |
| Product | tyrosine-protein phosphatase non-receptor type 20 isoform 4 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001042392, 109138564 |
| Protein | NP_001035851, 109138565 |
| Product | tyrosine-protein phosphatase non-receptor type 20 isoform 5 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001042395, 109138572 |
| Protein | NP_001035854, 109138573 |
| Product | tyrosine-protein phosphatase non-receptor type 20 isoform 8 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001042396, 109138570 |
| Protein | NP_001035855, 109138571 |
| Product | tyrosine-protein phosphatase non-receptor type 20 isoform 9 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001042397, 109138574 |
| Protein | NP_001035856, 109138575 |
| Product | tyrosine-protein phosphatase non-receptor type 20 isoform 10 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001042387, 109138558 |
| Protein | NP_001035846, 109138559 |
| Product | tyrosine-protein phosphatase non-receptor type 20 isoform 2 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001042389, 109138556 |
| Protein | NP_001035848, 109138557 |
| Product | tyrosine-protein phosphatase non-receptor type 20 isoform 1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001042393, 109138566 |
| Protein | NP_001035852, 109138567 |
| Product | tyrosine-protein phosphatase non-receptor type 20 isoform 6 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001042394, 109138568 |
| Protein | NP_001035853, 109138569 |
| Product | tyrosine-protein phosphatase non-receptor type 20 isoform 7 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | PTPN20B | NP_001035816.1 |
| Homo sapiens (human) | PTPN20A | NP_001035848.1 |
| Pan troglodytes (chimpanzee) | PTPN20A | XP_001136909.1 |
| Bos taurus (cattle) | LOC517883 | XP_001788066.1 |
| Mus musculus (house mouse) | Ptpn20 | NP_033004.1 |
| Rattus norvegicus (Norway rat) | Ptpn20 | XP_224639.4 |
| Arabidopsis thaliana (thale cress) | PTP1 | NP_177331.1 |
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005737 | cytoplasm | IEA |
| GO:0005815 | microtubule organizing center | IEA |
| GO:0005856 | cytoskeleton | IEA |
| GO:0005874 | microtubule | IEA |
Function
| ID | Name | Evidence |
| GO:0004725 | protein tyrosine phosphatase activity | IEA |
| GO:0016787 | hydrolase activity | IEA |
| GeneCards | PTPN20A |
| MIM | 610630 |
| Ensembl | ENSG00000204179 |
| HGNC | 23422 |
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