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Lrrk2 leucine-rich repeat kinase 2 [Mus musculus (house mouse)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_025730 Mus musculus leucine-rich repeat kinase 2 (Lrrk2), mRNA. GenEZ ORF Cloning In-stock $2448.00 $2399.00 24
XM_006521276 PREDICTED: Mus musculus leucine-rich repeat kinase 2 (Lrrk2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $3749.00 35
XM_006521277 PREDICTED: Mus musculus leucine-rich repeat kinase 2 (Lrrk2), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $3749.00 35

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Gene Symbol Lrrk2
Entrez Gene ID 66725
Full Name leucine-rich repeat kinase 2
Synonyms 4921513O20Rik, 9330188B09Rik, AW561911, D630001M17Rik, Gm927, cI-46
General protein information
Preferred Names
leucine-rich repeat serine/threonine-protein kinase 2
leucine-rich repeat serine/threonine-protein kinase 2
Gene Type protein-coding
Organism Mus musculus (house mouse)


15|15 F1



mRNA Protein Product Sequence Price Select
NM_025730, 146231953 NP_080006, 146231954 leucine-rich repeat serine/threonine-protein kinase 2 ORF Sequence $2199.00
XM_006521276, 568993080 XP_006521339, 568993081 leucine-rich repeat serine/threonine-protein kinase 2 isoform X1 ORF Sequence $3500.00
XM_006521277, 568993082 XP_006521340, 568993083 leucine-rich repeat serine/threonine-protein kinase 2 isoform X2 ORF Sequence $3500.00
mmu05012Parkinson's disease
WP2309XPodNet - protein-protein interactions in the podocyte expanded by STRING
Homo sapiens (human)LRRK2NP_940980.3
Pan troglodytes (chimpanzee)LRRK2XP_001168494.1
Macaca mulatta (Rhesus monkey)LRRK2XP_002798616.1
Canis lupus familiaris (dog)LRRK2XP_543734.3
Bos taurus (cattle)LRRK2NP_001193015.1
Mus musculus (house mouse)Lrrk2NP_080006.3
Rattus norvegicus (Norway rat)Lrrk2NP_001178718.1
Gallus gallus (chicken)LRRK2XP_003640388.2
Danio rerio (zebrafish)lrrk2NP_001188385.1
Xenopus (Silurana) tropicalis (western clawed frog)lrrk2XP_002932250.2
GO:0000165MAPK cascadeISO
GO:0000186activation of MAPKK activityISO
GO:0000187activation of MAPK activityISO
GO:0001934positive regulation of protein phosphorylationISO
GO:0006184GTP catabolic processISO
GO:0006468protein phosphorylationISA
GO:0006979response to oxidative stressISO
GO:0007264small GTPase mediated signal transductionIEA
GO:0007528neuromuscular junction developmentISO
GO:0008340determination of adult lifespanISO
GO:0010508positive regulation of autophagyIMP
GO:0010508positive regulation of autophagyISO
GO:0014041regulation of neuron maturationISO
GO:0018105peptidyl-serine phosphorylationISO
GO:0018107peptidyl-threonine phosphorylationISO
GO:0021772olfactory bulb developmentISO
GO:0022028tangential migration from the subventricular zone to the olfactory bulbISO
GO:0031398positive regulation of protein ubiquitinationISO
GO:0032091negative regulation of protein bindingISO
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processIMP
GO:0034260negative regulation of GTPase activityISO
GO:0035564regulation of kidney sizeIMP
GO:0035640exploration behaviorISO
GO:0040012regulation of locomotionISO
GO:0042391regulation of membrane potentialISO
GO:0043068positive regulation of programmed cell deathISO
GO:0043547positive regulation of GTPase activityISO
GO:0046777protein autophosphorylationISA
GO:0046777protein autophosphorylationISO
GO:0048312intracellular distribution of mitochondriaISO
GO:0051900regulation of mitochondrial depolarizationISO
GO:0060161positive regulation of dopamine receptor signaling pathwayISO
GO:0061001regulation of dendritic spine morphogenesisISO
GO:0070997neuron deathISO
GO:1901214regulation of neuron deathISO
GO:1902692regulation of neuroblast proliferationISO
GO:2000172regulation of branching morphogenesis of a nerveISO
GO:2000300regulation of synaptic vesicle exocytosisISO
GO:0005615extracellular spaceISO
GO:0005802trans-Golgi networkIDA
GO:0005886plasma membraneIDA
GO:0008021synaptic vesicleIDA
GO:0016234inclusion bodyISO
GO:0031966mitochondrial membraneISO
GO:0032473cytoplasmic side of mitochondrial outer membraneISO
GO:0032839dendrite cytoplasmISO
GO:0043005neuron projectionISO
GO:0043025neuronal cell bodyISO
GO:0043231intracellular membrane-bounded organelleISO
GO:0045121membrane raftIDA
GO:0070062extracellular vesicular exosomeISO
GO:0000149SNARE bindingISO
GO:0000166nucleotide bindingIEA
GO:0001948glycoprotein bindingISO
GO:0003779actin bindingISO
GO:0003924GTPase activityISO
GO:0004672protein kinase activityISO
GO:0004674protein serine/threonine kinase activityISO
GO:0004708MAP kinase kinase activityISO
GO:0005096GTPase activator activityISO
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0005525GTP bindingISA
GO:0005525GTP bindingISO
GO:0015631tubulin bindingISO
GO:0016301kinase activityIEA
GO:0016740transferase activityIEA
GO:0016772transferase activity, transferring phosphorus-containing groupsIEA
GO:0017048Rho GTPase bindingIPI
GO:0017048Rho GTPase bindingISO
GO:0017075syntaxin-1 bindingISO
GO:0030276clathrin bindingISO
GO:0034211GTP-dependent protein kinase activityISA
GO:0034211GTP-dependent protein kinase activityISO
GO:0042802identical protein bindingIPI
GO:0042802identical protein bindingISO
GO:0042803protein homodimerization activityISO
GO:0044325ion channel bindingISO
GO:0051018protein kinase A bindingISO
GeneCards Lrrk2
UniProt Q9CQG8, Q5S006
MGI 1913975
Vega OTTMUSG00000020864
Ensembl ENSMUSG00000036273

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

What is the normal function of the LRRK2 gene?

The LRRK2 gene provides instructions for making a protein called dardarin. The LRRK2 gene is active in the brain and other tissues throughout the body.

One segment of the dardarin protein is called a leucine-rich region because it contains a large amount of a protein building block (amino acid) known as leucine. Proteins with leucine-rich regions appear to play a role in activities that require interactions with other proteins, such as transmitting signals or helping to assemble the cell's structural framework (cytoskeleton). Other parts of the dardarin protein are also thought to be involved in protein-protein interactions.

Additional studies indicate that dardarin has an enzyme function known as kinase activity. Proteins with kinase activity assist in the transfer of a phosphate group (a cluster of oxygen and phosphorus atoms) from the energy molecule ATP to amino acids in certain proteins. This phosphate transfer is called phosphorylation, and it is an essential step in turning on and off many cell activities. Dardarin also has a second enzyme function referred to as a GTPase activity. This activity is associated with a region of the protein called the ROC domain. The ROC domain may help control the overall shape of the dardarin protein.


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