Whsc1 Wolf-Hirschhorn syndrome candidate 1 (human) [Rattus norvegicus (Norway rat)]
| Gene Symbol | Whsc1 |
| Entrez Gene ID | 680537 |
| Full Name | Wolf-Hirschhorn syndrome candidate 1 (human) |
| Synonyms | RGD1565590 |
| Gene Type | protein-coding |
| Organism | Rattus norvegicus (Norway rat) |
| Genome |
14 14q21 |
| Summary | |
| Disorder | MIM: |
| mRNA | XM_002724986, 293341802 |
| Protein | XP_002725032, 293341803 |
| Product | Wolf-Hirschhorn syndrome candidate 1 (human) isoform 1 |
| RefSeq Status | MODEL |
| mRNA | XM_002724987, 293341804 |
| Protein | XP_002725033, 293341805 |
| Product | Wolf-Hirschhorn syndrome candidate 1 (human) isoform 2 |
| RefSeq Status | MODEL |
| mRNA | XM_001058474, 293353237 |
| Protein | XP_001058474, 109499886 |
| Product | Wolf-Hirschhorn syndrome candidate 1 isoform 3 |
| RefSeq Status | MODEL |
| mRNA | NM_001191552, 300796852 |
| Protein | NP_001178481, 300796853 |
| Product | probable histone-lysine N-methyltransferase NSD2 |
| RefSeq Status | PROVISIONAL |
| rno00310 | Lysine degradation |
| Homo sapiens (human) | WHSC1 | NP_001035889.1 |
| Pan troglodytes (chimpanzee) | WHSC1 | XP_517068.2 |
| Canis lupus familiaris (dog) | WHSC1 | XP_536224.2 |
| Bos taurus (cattle) | WHSC1 | XP_613048.2 |
| Mus musculus (house mouse) | Whsc1 | NP_001074571.1 |
| Rattus norvegicus (Norway rat) | Whsc1 | XP_001058413.1 |
| Gallus gallus (chicken) | WHSC1 | XP_420839.2 |
| Danio rerio (zebrafish) | whsc1 | NP_001076020.1 |
| Drosophila melanogaster (fruit fly) | Mes-4 | NP_733239.1 |
| ID | Name | Evidence |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | ISO |
| GO:0003149 | membranous septum morphogenesis | IEA |
| GO:0003149 | membranous septum morphogenesis | ISO |
| GO:0003289 | atrial septum primum morphogenesis | IEA |
| GO:0003289 | atrial septum primum morphogenesis | ISO |
| GO:0003290 | atrial septum secundum morphogenesis | IEA |
| GO:0003290 | atrial septum secundum morphogenesis | ISO |
| GO:0008150 | biological_process | ND |
| GO:0016568 | chromatin modification | IEA |
| GO:0016568 | chromatin modification | ISO |
| GO:0018022 | peptidyl-lysine methylation | ISO |
| GO:0034968 | histone lysine methylation | ISO |
| GO:0060348 | bone development | IEA |
| GO:0060348 | bone development | ISO |
Component
| ID | Name | Evidence |
| GO:0005575 | cellular_component | ND |
| GO:0005634 | nucleus | IEA |
| GO:0005634 | nucleus | ISO |
| GO:0005730 | nucleolus | IEA |
| GO:0005730 | nucleolus | ISO |
| GO:0031965 | nuclear membrane | IEA |
| GO:0031965 | nuclear membrane | ISO |
Function
| ID | Name | Evidence |
| GO:0003674 | molecular_function | ND |
| GO:0003677 | DNA binding | IEA |
| GO:0003682 | chromatin binding | IEA |
| GO:0003682 | chromatin binding | ISO |
| GO:0008168 | methyltransferase activity | IEA |
| GO:0008270 | zinc ion binding | IEA |
| GO:0016740 | transferase activity | IEA |
| GO:0018024 | histone-lysine N-methyltransferase activity | IEA |
| GO:0018024 | histone-lysine N-methyltransferase activity | ISO |
| GO:0046872 | metal ion binding | IEA |
| GeneCards | Whsc1 |
| RGD | 1307955 |
| Ensembl | ENSRNOG00000038140 |
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