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Whsc1 Wolf-Hirschhorn syndrome candidate 1 [Rattus norvegicus (Norway rat)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001191552 Rattus norvegicus Wolf-Hirschhorn syndrome candidate 1 (Whsc1), mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006251372 PREDICTED: Rattus norvegicus Wolf-Hirschhorn syndrome candidate 1 (Whsc1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006251373 PREDICTED: Rattus norvegicus Wolf-Hirschhorn syndrome candidate 1 (Whsc1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006251374 PREDICTED: Rattus norvegicus Wolf-Hirschhorn syndrome candidate 1 (Whsc1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006251375 PREDICTED: Rattus norvegicus Wolf-Hirschhorn syndrome candidate 1 (Whsc1), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006251376 PREDICTED: Rattus norvegicus Wolf-Hirschhorn syndrome candidate 1 (Whsc1), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006251377 PREDICTED: Rattus norvegicus Wolf-Hirschhorn syndrome candidate 1 (Whsc1), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006251378 PREDICTED: Rattus norvegicus Wolf-Hirschhorn syndrome candidate 1 (Whsc1), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006251379 PREDICTED: Rattus norvegicus Wolf-Hirschhorn syndrome candidate 1 (Whsc1), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

Related Services

Gene Symbol Whsc1
Entrez Gene ID 680537
Full Name Wolf-Hirschhorn syndrome candidate 1
Synonyms RGD1565590
General protein information
Preferred Names
probable histone-lysine N-methyltransferase NSD2
Names
probable histone-lysine N-methyltransferase NSD2
NP_001178481.1
Gene Type protein-coding
Organism Rattus norvegicus (Norway rat)
Genome

14

14q21

Summary
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_001191552, 300796852 NP_001178481, 300796853 probable histone-lysine N-methyltransferase NSD2 ORF Sequence $1500.00
XM_006251372, 564384609 XP_006251434, 564384610 probable histone-lysine N-methyltransferase NSD2 isoform X1 ORF Sequence $1500.00
XM_006251373, 564384611 XP_006251435, 564384612 probable histone-lysine N-methyltransferase NSD2 isoform X2 ORF Sequence $1500.00
XM_006251374, 564384613 XP_006251436, 564384614 probable histone-lysine N-methyltransferase NSD2 isoform X3 ORF Sequence $1500.00
XM_006251375, 564384615 XP_006251437, 564384616 probable histone-lysine N-methyltransferase NSD2 isoform X4 ORF Sequence $1500.00
XM_006251376, 564384617 XP_006251438, 564384618 probable histone-lysine N-methyltransferase NSD2 isoform X5 ORF Sequence $1500.00
XM_006251377, 564384619 XP_006251439, 564384620 probable histone-lysine N-methyltransferase NSD2 isoform X6 ORF Sequence $1500.00
XM_006251378, 564384621 XP_006251440, 564384622 probable histone-lysine N-methyltransferase NSD2 isoform X7 ORF Sequence $1500.00
XM_006251379, 564384623 XP_006251441, 564384624 probable histone-lysine N-methyltransferase NSD2 isoform X8 ORF Sequence $700.00
KEGG
rno00310Lysine degradation
rno05202Transcriptional misregulation in cancer
Homo sapiens (human)WHSC1NP_579877.1
Pan troglodytes (chimpanzee)WHSC1XP_001146473.1
Macaca mulatta (Rhesus monkey)LOC712618XP_002802212.1
Canis lupus familiaris (dog)WHSC1XP_536224.4
Bos taurus (cattle)WHSC1XP_005208360.1
Mus musculus (house mouse)Whsc1NP_001074571.2
Rattus norvegicus (Norway rat)Whsc1NP_001178481.1
Gallus gallus (chicken)WHSC1XP_420839.3
Danio rerio (zebrafish)whsc1NP_001076020.1
Xenopus (Silurana) tropicalis (western clawed frog)whsc1XP_002936809.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0000122negative regulation of transcription from RNA polymerase II promoterISO
GO:0003149membranous septum morphogenesisIEA
GO:0003149membranous septum morphogenesisISO
GO:0003289atrial septum primum morphogenesisIEA
GO:0003289atrial septum primum morphogenesisISO
GO:0003290atrial septum secundum morphogenesisIEA
GO:0003290atrial septum secundum morphogenesisISO
GO:0008150biological_processND
GO:0016568chromatin modificationISO
GO:0018022peptidyl-lysine methylationISO
GO:0034968histone lysine methylationIEA
GO:0034968histone lysine methylationISO
GO:0060348bone developmentIEA
GO:0060348bone developmentISO
Component
IDNameEvidence
GO:0005575cellular_componentND
GO:0005634nucleusISO
GO:0005730nucleolusIEA
GO:0005730nucleolusISO
GO:0031965nuclear membraneIEA
GO:0031965nuclear membraneISO
Function
IDNameEvidence
GO:0003674molecular_functionND
GO:0003682chromatin bindingIEA
GO:0003682chromatin bindingISO
GO:0008270zinc ion bindingIEA
GO:0018024histone-lysine N-methyltransferase activityIEA
GO:0018024histone-lysine N-methyltransferase activityISO
GeneCards Whsc1
UniProt D4A9J4
RGD 1307955
Ensembl ENSRNOG00000038140

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the WHSC1 gene?

The WHSC1 gene (also known as MMSET) provides instructions for making at least three very similar proteins known as MMSET I, MMSET II, and RE-IIBP. These proteins are active both before and after birth in many of the body's cells and tissues. They appear to play an important role in normal development.

At least two of the proteins produced from the WHSC1 gene, MMSET II and RE-IIBP, likely help regulate the activity of other genes. Studies suggest that these proteins function as histone methyltransferases, which are enzymes that modify DNA-associated proteins called histones. By adding a molecule called a methyl group to histones, histone methyltransferases can turn off (suppress) the activity of certain genes. Scientists are working to identify the genes targeted by the MMSET II and RE-IIBP proteins.

Interactant

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