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T T, brachyury homolog (mouse) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001270484 Homo sapiens T, brachyury homolog (mouse) (T), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_003181 Homo sapiens T, brachyury homolog (mouse) (T), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Gene Symbol T
Entrez Gene ID 6862
Full Name T, brachyury homolog (mouse)
Synonyms SAVA, TFT
General protein information
Preferred Names
brachyury protein
Names
brachyury protein
protein T
T brachyury homolog
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q27

Summary The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012].
Disorder

MIM: 601397

{Neural tube defects, susceptibility to}, 182940 (3)

mRNA Protein Product Sequence Price Select
NM_001270484, 394953946 NP_001257413, 394953947 brachyury protein isoform 2 ORF Sequence $400.00
NM_003181, 394953944 NP_003172, 4507339 brachyury protein isoform 1 ORF Sequence $360.00
WikiPathways
WP2406Cardiac Progenitor Differentiation
Pathway Interaction Database
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
BIOCYC
HUMAN_GLYCLEAV-PWYglycine cleavage
Homo sapiens (human)TNP_003172.1
Pan troglodytes (chimpanzee)TXP_527563.3
Macaca mulatta (Rhesus monkey)TXP_001101514.1
Canis lupus familiaris (dog)TNP_001003092.1
Bos taurus (cattle)TNP_001179914.1
Mus musculus (house mouse)TNP_033335.1
Rattus norvegicus (Norway rat)TNP_001099679.1
Gallus gallus (chicken)TNP_990271.1
Danio rerio (zebrafish)LOC100004296XP_001343633.3
Xenopus (Silurana) tropicalis (western clawed frog)tNP_001008139.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterISS
GO:0001570vasculogenesisIEA
GO:0001756somitogenesisIEA
GO:0001839neural plate morphogenesisIEA
GO:0001843neural tube closureIEA
GO:0003007heart morphogenesisIDA
GO:0003257positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationIDA
GO:0006366transcription from RNA polymerase II promoterIEA
GO:0007165signal transductionNAS
GO:0007341penetration of zona pellucidaIEA
GO:0007498mesoderm developmentTAS
GO:0007509mesoderm migration involved in gastrulationIEA
GO:0008284positive regulation of cell proliferationIEA
GO:0008595anterior/posterior axis specification, embryoTAS
GO:0014028notochord formationIEA
GO:0023019signal transduction involved in regulation of gene expressionIEA
GO:0030509BMP signaling pathwayIEA
GO:0036342post-anal tail morphogenesisIEA
GO:0048706embryonic skeletal system developmentIEA
GO:0060070canonical Wnt signaling pathwayIEA
GO:0060349bone morphogenesisIEA
GO:0060395SMAD protein signal transductionIEA
GO:0061371determination of heart left/right asymmetryIEA
GO:0090009primitive streak formationNAS
Component
IDNameEvidence
GO:0000790nuclear chromatinIDA
GO:0005737cytoplasmIEA
Function
IDNameEvidence
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingISS
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIDA
GO:0001085RNA polymerase II transcription factor bindingISS
GO:0001102RNA polymerase II activating transcription factor bindingIPI
GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptionISS
GO:0003700sequence-specific DNA binding transcription factor activityNAS
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIDA
GeneCards T
UniProt O15178
Vega OTTHUMG00000015991
MIM 601397
Ensembl ENSG00000164458
HGNC 11515
HPRD 03236

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the T gene?

The T gene provides instructions for making a protein called brachyury. Brachyury is a member of a protein family called T-box proteins, which play critical roles during embryonic development. T-box proteins regulate the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, T-box proteins are called transcription factors.

The brachyury protein is important for the development of the notochord, which is the precursor of the spinal column in the embryo. The notochord disappears before birth, but in a small percentage of individuals, some of its cells remain in the base of the skull or in the spine. The notochord helps control the development of the neural tube, which is a layer of cells that ultimately develops into the brain and spinal cord.

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