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TERC telomerase RNA component [Homo sapiens (human)]


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Gene Symbol TERC
Entrez Gene ID 7012
Full Name telomerase RNA component
Synonyms DKCA1, PFBMFT2, SCARNA19, TR, TRC3, hTR
General protein information
Gene Type ncRNA
Organism Homo sapiens (human)
Genome

3

3q26

Summary
Disorder

MIM: 602322

Dyskeratosis congenita, autosomal dominant, 127550 (3); Aplastic

mRNA Protein Product Sequence Price Select
GeneCards TERC
MIM 602322
Ensembl ENSG00000270141
HGNC 11727

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the TERC gene?

The TERC gene provides instructions for making one component of an enzyme called telomerase. Telomerase maintains structures called telomeres, which are composed of repeated segments of DNA found at the ends of chromosomes. Telomeres protect chromosomes from abnormally sticking together or breaking down (degrading). In most cells, telomeres become progressively shorter as the cell divides. After a certain number of cell divisions, the telomeres become so short that they trigger the cell to stop dividing or to self-destruct (undergo apoptosis). Telomerase counteracts the shortening of telomeres by adding small repeated segments of DNA to the ends of chromosomes each time the cell divides.

In most types of cells, telomerase is either undetectable or active at very low levels. However, telomerase is highly active in cells that divide rapidly, such as cells that line the lungs and gastrointestinal tract, cells in bone marrow, and cells of the developing fetus. Telomerase allows these cells to divide many times without becoming damaged or undergoing apoptosis. Telomerase is also abnormally active in cancer cells, which grow and divide without control or order.

The telomerase enzyme consists of two major components that work together. The component produced from the TERC gene is known as hTR. The hTR component is an RNA molecule, a chemical cousin of DNA. It provides a template for creating the repeated sequence of DNA that telomerase adds to the ends of chromosomes. The other major component of telomerase, which is produced from a gene called TERT, is known as hTERT. The function of hTERT is to add the new DNA segment to chromosome ends.

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