WIPF1 WAS/WASL interacting protein family, member 1 [Homo sapiens (human)]
| Gene Symbol | WIPF1 |
| Entrez Gene ID | 7456 |
| Full Name | WAS/WASL interacting protein family, member 1 |
| Synonyms | MGC111041, PRPL-2, WASPIP, WIP |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
2 2q31.1 |
| Summary | This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]. |
| Disorder | MIM: 602357 |
| mRNA | NM_003387, 116284399 |
| Protein | NP_003378, 38373695 |
| Product | WAS/WASL-interacting protein family member 1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077269, 116284397 |
| Protein | NP_001070737, 116284398 |
| Product | WAS/WASL-interacting protein family member 1 |
| RefSeq Status | REVIEWED |
| WP69 | T Cell Receptor Signaling Pathway |
Pathway Interaction Database
| fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| Homo sapiens (human) | WIPF1 | NP_001070737.1 |
| Pan troglodytes (chimpanzee) | WIPF1 | XP_001150374.1 |
| Canis lupus familiaris (dog) | WIPF1 | XP_545531.2 |
| Bos taurus (cattle) | WIPF1 | NP_001070391.1 |
| Mus musculus (house mouse) | Wipf1 | NP_694778.1 |
| Rattus norvegicus (Norway rat) | Wipf1 | NP_476540.2 |
| Gallus gallus (chicken) | WIPF1 | NP_001012935.1 |
| Danio rerio (zebrafish) | LOC100151491 | XP_001919866.1 |
| ID | Name | Evidence |
| GO:0006461 | protein complex assembly | TAS |
| GO:0008154 | actin polymerization or depolymerization | TAS |
| GO:0030036 | actin cytoskeleton organization | IEA |
| GO:0030048 | actin filament-based movement | IEA |
| GO:0046827 | positive regulation of protein export from nucleus | IEA |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IEA |
| GO:0005884 | actin filament | IEA |
| GO:0015629 | actin cytoskeleton | TAS |
| GO:0016023 | cytoplasmic membrane-bounded vesicle | IEA |
Function
| ID | Name | Evidence |
| GO:0003779 | actin binding | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0005522 | profilin binding | TAS |
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