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Sequence in raw or FASTA format:

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XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17488 NM_022406 Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu17539 NM_022550 Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17539 NM_003401 Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17488 XM_005248595 PREDICTED: Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17488C NM_022406 Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu17539C NM_022550 Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu17539C NM_003401 Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu17488C XM_005248595 PREDICTED: Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol XRCC4
Entrez Gene ID 7518
Full Name X-ray repair complementing defective repair in Chinese hamster cells 4
Synonyms
General protein information
Preferred Names
DNA repair protein XRCC4
Names
DNA repair protein XRCC4
X-ray repair cross-complementing protein 4
X-ray repair, complementing defective, repair in Chinese hamster
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q14.2

Summary The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq, Sep 2008].
Disorder

MIM: 194363

mRNA Protein Product Sequence Price Select
NM_003401, 196162694 NP_003392, 4507945 DNA repair protein XRCC4 isoform 1 ORF Sequence $400.00
NM_022406, 196162693 NP_071801, 12408647 DNA repair protein XRCC4 isoform 2 ORF Sequence $269.00
NM_022550, 196162695 NP_072044, 12408649 DNA repair protein XRCC4 isoform 1 ORF Sequence $400.00
XM_005248595, 530379487 XP_005248652, 530379488 DNA repair protein XRCC4 isoform X1 ORF Sequence $400.00
KEGG
hsa03450Non-homologous end-joining
WikiPathways
WP438Non-homologous end joining
Reactome
REACT_1022Nonhomologous End-joining (NHEJ)
REACT_216DNA Repair
REACT_2054Double-Strand Break Repair
REACT_6256HIV Life Cycle
REACT_6185HIV Infection
REACT_6918Integration of provirus
REACT_90582-LTR circle formation
REACT_6266Early Phase of HIV Life Cycle
REACT_116125Disease
Homo sapiens (human)XRCC4NP_071801.1
Pan troglodytes (chimpanzee)XRCC4XP_001148110.2
Macaca mulatta (Rhesus monkey)LOC712291XP_001111862.1
Canis lupus familiaris (dog)XRCC4XP_005618208.1
Bos taurus (cattle)XRCC4NP_001075084.1
Mus musculus (house mouse)Xrcc4NP_082288.1
Rattus norvegicus (Norway rat)Xrcc4NP_001007000.1
Gallus gallus (chicken)XRCC4XP_424905.4
Danio rerio (zebrafish)xrcc4NP_957080.1
Xenopus (Silurana) tropicalis (western clawed frog)xrcc4NP_001106551.1
Process
IDNameEvidence
GO:0001701in utero embryonic developmentIEA
GO:0002328pro-B cell differentiationIEA
GO:0006281DNA repairTAS
GO:0006302double-strand break repairIDA
GO:0006302double-strand break repairTAS
GO:0006303double-strand break repair via nonhomologous end joiningIDA
GO:0006303double-strand break repair via nonhomologous end joiningIMP
GO:0006303double-strand break repair via nonhomologous end joiningNAS
GO:0006303double-strand break repair via nonhomologous end joiningTAS
GO:0007417central nervous system developmentIEA
GO:0010165response to X-rayIDA
GO:0010332response to gamma radiationIEA
GO:0016032viral processTAS
GO:0033077T cell differentiation in thymusIEA
GO:0033152immunoglobulin V(D)J recombinationIEA
GO:0043524negative regulation of neuron apoptotic processIEA
GO:0045190isotype switchingIEA
GO:0048146positive regulation of fibroblast proliferationIEA
GO:0050769positive regulation of neurogenesisIEA
GO:0051103DNA ligation involved in DNA repairIDA
GO:0051351positive regulation of ligase activityIDA
GO:0071285cellular response to lithium ionIEA
GO:0075713establishment of integrated proviral latencyTAS
Component
IDNameEvidence
GO:0000793condensed chromosomeIDA
GO:0005634nucleusIDA
GO:0005634nucleusNAS
GO:0005654nucleoplasmTAS
GO:0005730nucleolusIDA
GO:0005813centrosomeIDA
GO:0005829cytosolIDA
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complexIDA
GO:0030054cell junctionIDA
GO:0032807DNA ligase IV complexIDA
GO:0070419nonhomologous end joining complexIDA
Function
IDNameEvidence
GO:0003677DNA bindingIDA
GO:0005515protein bindingIPI
GO:0008022protein C-terminus bindingIPI
GO:0016874ligase activityIDA
GeneCards XRCC4
UniProt Q13426, Q7Z763
Vega OTTHUMG00000131319
MIM 194363
Ensembl ENSG00000152422
HGNC 12831
HPRD 15951

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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