Sequence in raw or FASTA format:
RNASEH2B ribonuclease H2, subunit B [Homo sapiens (human)]
| Gene Symbol | RNASEH2B |
| Entrez Gene ID | 79621 |
| Full Name | ribonuclease H2, subunit B |
| Synonyms | AGS2, DLEU8, FLJ11712 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
13 13q14.3 |
| Summary | RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq]. |
| Disorder | MIM: 610326 Aicardi-Goutieres syndrome 2, 610181 (3) |
| mRNA | NM_001142279, 326937470 |
| Protein | NP_001135751, 214010191 |
| Product | ribonuclease H2 subunit B isoform 2 |
| RefSeq Status | REVIEWED |
| mRNA | NM_024570, 326937471 |
| Protein | NP_078846, 186910286 |
| Product | ribonuclease H2 subunit B isoform 1 |
| RefSeq Status | REVIEWED |
| hsa03030 | DNA replication |
| Homo sapiens (human) | RNASEH2B | NP_078846.2 |
| Pan troglodytes (chimpanzee) | RNASEH2B | XP_001158221.1 |
| Canis lupus familiaris (dog) | RNASEH2B | XP_848995.1 |
| Bos taurus (cattle) | RNASEH2B | XP_586184.4 |
| Mus musculus (house mouse) | Rnaseh2b | NP_080277.1 |
| Rattus norvegicus (Norway rat) | Rnaseh2b | NP_001007008.1 |
| Gallus gallus (chicken) | RNASEH2B | NP_001025997.1 |
| Danio rerio (zebrafish) | rnaseh2b | NP_956565.1 |
| Drosophila melanogaster (fruit fly) | CG11164 | NP_572908.2 |
| ID | Name | Evidence |
| GO:0006401 | RNA catabolic process | IDA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0032299 | ribonuclease H2 complex | IDA |
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