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RNASEH2B ribonuclease H2, subunit B [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001142279 Homo sapiens ribonuclease H2, subunit B (RNASEH2B), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_024570 Homo sapiens ribonuclease H2, subunit B (RNASEH2B), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005266524 PREDICTED: Homo sapiens ribonuclease H2, subunit B (RNASEH2B), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005266525 PREDICTED: Homo sapiens ribonuclease H2, subunit B (RNASEH2B), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006719867 PREDICTED: Homo sapiens ribonuclease H2, subunit B (RNASEH2B), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $449.00 14

*Business Day

Related Services

Gene Symbol RNASEH2B
Entrez Gene ID 79621
Full Name ribonuclease H2, subunit B
Synonyms AGS2, DLEU8
General protein information
Preferred Names
ribonuclease H2 subunit B
Names
ribonuclease H2 subunit B
RNase H2 subunit B
ribonuclease HI subunit B
deleted in lymphocytic leukemia 8
Aicardi-Goutieres syndrome 2 protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q14.3

Summary RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008].
Disorder

MIM: 610326

Aicardi-Goutieres syndrome 2, 610181 (3)

mRNA Protein Product Sequence Price Select
NM_001142279, 326937470 NP_001135751, 214010191 ribonuclease H2 subunit B isoform 2 ORF Sequence $300.00
NM_024570, 326937471 NP_078846, 186910286 ribonuclease H2 subunit B isoform 1 ORF Sequence $300.00
XM_005266524, 530402643 XP_005266581, 530402644 ribonuclease H2 subunit B isoform X1 ORF Sequence $300.00
XM_005266525, 530402645 XP_005266582, 530402646 ribonuclease H2 subunit B isoform X2 ORF Sequence $300.00
XM_006719867, 578825006 XP_006719930, 578825007 ribonuclease H2 subunit B isoform X3 ORF Sequence $300.00
KEGG
hsa03030DNA replication
Homo sapiens (human)RNASEH2BNP_078846.2
Pan troglodytes (chimpanzee)RNASEH2BXP_001158221.1
Macaca mulatta (Rhesus monkey)LOC707995XP_001105134.1
Canis lupus familiaris (dog)LOC607281XP_005634133.1
Bos taurus (cattle)RNASEH2BNP_001160038.1
Mus musculus (house mouse)Rnaseh2bNP_080277.1
Rattus norvegicus (Norway rat)Rnaseh2bNP_001007008.1
Gallus gallus (chicken)RNASEH2BNP_001025997.1
Danio rerio (zebrafish)rnaseh2bNP_956565.1
Drosophila melanogaster (fruit fly)CG11164NP_572908.2
Xenopus (Silurana) tropicalis (western clawed frog)rnaseh2bNP_001016329.1
Process
IDNameEvidence
GO:0001701in utero embryonic developmentIEA
GO:0006401RNA catabolic processIDA
GO:0009259ribonucleotide metabolic processIEA
GO:0010389regulation of G2/M transition of mitotic cell cycleIEA
GO:0010629negative regulation of gene expressionIEA
GO:0048146positive regulation of fibroblast proliferationIEA
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolyticIEA
GO:2000001regulation of DNA damage checkpointIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0032299ribonuclease H2 complexIDA
Function
IDNameEvidence
GO:0004523RNA-DNA hybrid ribonuclease activityIEA
GeneCards RNASEH2B
PDB 3P87, 3PUF, 3P56
UniProt Q8N451, Q5TBB1
Vega OTTHUMG00000016937
MIM 610326
Ensembl ENSG00000136104
HGNC 25671

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the RNASEH2B gene?

The RNASEH2B gene provides instructions for making one part (subunit) of a group of proteins called the RNase H2 complex. This complex is a ribonuclease, which means it is an enzyme that helps break down RNA, a chemical cousin of DNA. In particular, the RNase H2 complex helps break down molecules in which one strand of RNA is combined with one strand of DNA (RNA-DNA hybrids). These hybrids are formed during DNA copying (replication) and are found in all cells.

The RNase H2 complex is involved in DNA replication, error repair, and other cellular functions. Researchers believe that these additional functions may include helping to prevent inappropriate immune system activation.

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