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MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002360 Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
XM_005249851 PREDICTED: Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006715773 PREDICTED: Homo sapiens v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $399.00 14

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Related Services

Gene Symbol MAFK
Entrez Gene ID 7975
Full Name v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
Synonyms NFE2U, P18
General protein information
Preferred Names
transcription factor MafK
Names
transcription factor MafK
nuclear factor erythroid-2, ubiquitous (p18)
basic-leucine zipper transcription factor MafK
erythroid transcription factor NF-E2 p18 subunit
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K
v-maf avian musculoaponeurotic fibrosarcoma oncogene family, protein K
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7p22.3

Summary The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008].
Disorder

MIM: 600197

mRNA Protein Product Sequence Price Select
NM_002360, 82617644 NP_002351, 4505075 transcription factor MafK ORF Sequence $159.00
XM_005249851, 530384988 XP_005249908, 530384989 transcription factor MafK isoform X1 ORF Sequence $300.00
XM_006715773, 578813624 XP_006715836, 578813625 transcription factor MafK isoform X2 ORF Sequence $250.00
Reactome
REACT_604Hemostasis
REACT_24970Factors involved in megakaryocyte development and platelet production
Homo sapiens (human)MAFKNP_002351.1
Macaca mulatta (Rhesus monkey)LOC721769XP_001117972.1
Canis lupus familiaris (dog)MAFKXP_003639134.1
Bos taurus (cattle)MAFKNP_001193229.1
Mus musculus (house mouse)MafkNP_034887.1
Rattus norvegicus (Norway rat)MafkNP_663706.2
Gallus gallus (chicken)MAFKNP_990087.1
Danio rerio (zebrafish)mafkNP_001002044.2
Drosophila melanogaster (fruit fly)maf-SNP_611500.1
Xenopus (Silurana) tropicalis (western clawed frog)mafkNP_001090663.1
Process
IDNameEvidence
GO:0006351transcription, DNA-templatedIEA
GO:0006355regulation of transcription, DNA-templatedIEA
GO:0007399nervous system developmentIEA
GO:0007596blood coagulationTAS
Component
IDNameEvidence
GO:0005654nucleoplasmTAS
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0043565sequence-specific DNA bindingIEA
GeneCards MAFK
UniProt O60675
Vega OTTHUMG00000151453
MIM 600197
Ensembl ENSG00000198517
HGNC 6782
HPRD 02561

Interactant

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