ZFP91 zinc finger protein 91 homolog (mouse) [Homo sapiens (human)]
| Gene Symbol | ZFP91 |
| Entrez Gene ID | 80829 |
| Full Name | zinc finger protein 91 homolog (mouse) |
| Synonyms | DMS-8, DSM-8, FLJ57065, PZF, ZFP-91, ZNF757 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
11 11q12 |
| Summary | The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq]. |
| Disorder | MIM: |
| mRNA | NM_001197051, 308081963 |
| Protein | NP_001183980, 308081964 |
| Product | E3 ubiquitin-protein ligase ZFP91 isoform 2 |
| RefSeq Status | REVIEWED |
| mRNA | NM_053023, 308081956 |
| Protein | NP_444251, 16579828 |
| Product | E3 ubiquitin-protein ligase ZFP91 isoform 1 |
| RefSeq Status | REVIEWED |
| WP61 | Delta-Notch Signaling Pathway |
| Homo sapiens (human) | ZFP91 | NP_444251.1 |
| Pan troglodytes (chimpanzee) | ZFP91 | XP_522004.2 |
| Canis lupus familiaris (dog) | ZFP91 | XP_533171.2 |
| Mus musculus (house mouse) | Zfp91 | NP_443735.2 |
| Rattus norvegicus (Norway rat) | Zfp91 | XP_001078426.1 |
| Gallus gallus (chicken) | ZFP91 | XP_001231964.1 |
| Danio rerio (zebrafish) | si:ch211-113e8.10 | XP_683275.2 |
| ID | Name | Evidence |
| GO:0007250 | activation of NF-kappaB-inducing kinase activity | IDA |
| GO:0070534 | protein K63-linked ubiquitination | IDA |
Component
| ID | Name | Evidence |
| GO:0005622 | intracellular | IEA |
| GO:0005634 | nucleus | IDA |
| GO:0005730 | nucleolus | IDA |
| GO:0043231 | intracellular membrane-bounded organelle | IDA |
Function
| ID | Name | Evidence |
| GO:0003676 | nucleic acid binding | IEA |
| GO:0004842 | ubiquitin-protein ligase activity | IDA |
| GO:0008270 | zinc ion binding | IEA |
| GO:0016874 | ligase activity | IEA |
| GO:0046872 | metal ion binding | IEA |
| GeneCards | ZFP91 |
| UniProt | Q96JP5 |
| Ensembl | ENSG00000255073 |
| HGNC | 14983 |
| HPRD | 11700 |
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