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Sequence in raw or FASTA format:


Blast Method:


CFHR5 complement factor H-related 5 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_030787 Homo sapiens complement factor H-related 5 (CFHR5), mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

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Gene Symbol CFHR5
Entrez Gene ID 81494
Full Name complement factor H-related 5
Synonyms CFHL5, CFHR5D, FHR-5, FHR5
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010].

MIM: 608593

mRNA Protein Product Sequence Price Select
NM_030787, 164607154 NP_110414, 13540563 complement factor H-related protein 5 precursor ORF Sequence $700.00
Homo sapiens (human)CFHR5NP_110414.1
Pan troglodytes (chimpanzee)CFHR5XP_514078.3
Canis lupus familiaris (dog)CFHR5XP_547381.3
GO:0006957complement activation, alternative pathwayNAS
GO:0005576extracellular regionNAS
GeneCards CFHR5
UniProt Q9BXR6
Vega OTTHUMG00000036517
MIM 608593
Ensembl ENSG00000134389
HGNC 24668
HPRD 06508

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CFHR5 gene?

The CFHR5 gene provides instructions for making a protein called complement factor H-related 5. The precise function of this protein is unknown. However, its structure is similar to that of a protein called complement factor H (which is produced from the CFH gene). This similarity provides clues to the probable function of complement factor H-related 5.

Complement factor H regulates a part of the body's immune response known as the complement system. The complement system is a group of proteins that work together to destroy foreign invaders (such as bacteria and viruses), trigger inflammation, and remove debris from cells and tissues. This system must be carefully regulated so it targets only unwanted materials and does not attack the body's healthy cells. Complement factor H helps to protect healthy cells by preventing activation of the complement system when it is not needed. Studies suggest that complement factor H-related 5 probably plays a related role in controlling the complement system.


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