Sequence in raw or FASTA format:
CFHR5 complement factor H-related 5 [Homo sapiens (human)]
|Entrez Gene ID||81494|
|Full Name||complement factor H-related 5|
|Synonyms||CFHL5, CFHR5D, FHR-5, FHR5|
|General protein information|
|Organism||Homo sapiens (human)|
|Summary||This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010].|
|Homo sapiens (human)||CFHR5||NP_110414.1|
|Pan troglodytes (chimpanzee)||CFHR5||XP_514078.3|
|Canis lupus familiaris (dog)||CFHR5||XP_547381.3|
|GO:0006957||complement activation, alternative pathway||NAS|
What is the normal function of the CFHR5 gene?
The CFHR5 gene provides instructions for making a protein called complement factor H-related 5. The precise function of this protein is unknown. However, its structure is similar to that of a protein called complement factor H (which is produced from the CFH gene). This similarity provides clues to the probable function of complement factor H-related 5.
Complement factor H regulates a part of the body's immune response known as the complement system. The complement system is a group of proteins that work together to destroy foreign invaders (such as bacteria and viruses), trigger inflammation, and remove debris from cells and tissues. This system must be carefully regulated so it targets only unwanted materials and does not attack the body's healthy cells. Complement factor H helps to protect healthy cells by preventing activation of the complement system when it is not needed. Studies suggest that complement factor H-related 5 probably plays a related role in controlling the complement system.
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