Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [Rattus norvegicus (Norway rat)]
| Gene Symbol | Atic |
| Entrez Gene ID | 81643 |
| Full Name | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
| Synonyms | |
| Gene Type | protein-coding |
| Organism | Rattus norvegicus (Norway rat) |
| Genome |
9 9q33 |
| Summary | catalyzes the final two steps of de novo purine biosynthesis [RGD]. |
| Disorder | MIM: |
| mRNA | NM_031014, 48675844 |
| Protein | NP_112276, 48675845 |
| Product | bifunctional purine biosynthesis protein PURH |
| RefSeq Status | PROVISIONAL |
| rno01100 | Metabolic pathways |
| rno00670 | One carbon pool by folate |
| rno00230 | Purine metabolism |
Reactome
| 1235530 | Purine metabolism |
| 1235529 | Purine ribonucleoside monophosphate biosynthesis |
| 1235496 | Metabolism of nucleotides |
| Homo sapiens (human) | ATIC | NP_004035.2 |
| Pan troglodytes (chimpanzee) | ATIC | XP_001150375.1 |
| Canis lupus familiaris (dog) | ATIC | XP_863050.1 |
| Bos taurus (cattle) | ATIC | NP_001068722.1 |
| Mus musculus (house mouse) | Atic | NP_080471.1 |
| Rattus norvegicus (Norway rat) | Atic | NP_112276.2 |
| Gallus gallus (chicken) | ATIC | NP_990509.1 |
| Danio rerio (zebrafish) | atic | NP_001076265.2 |
| Drosophila melanogaster (fruit fly) | CG11089 | NP_651305.1 |
| Caenorhabditis elegans | transferase | NP_741452.2 |
| Arabidopsis thaliana (thale cress) | AT2G35040 | NP_850240.1 |
| ID | Name | Evidence |
| GO:0006164 | purine nucleotide biosynthetic process | IEA |
| GO:0006189 | 'de novo' IMP biosynthetic process | NAS |
| GO:0009168 | purine ribonucleoside monophosphate biosynthetic process | ISO |
| GO:0031100 | organ regeneration | IEP |
Component
| ID | Name | Evidence |
| GO:0005575 | cellular_component | ND |
| GO:0005739 | mitochondrion | IEA |
| GO:0005739 | mitochondrion | ISO |
Function
| ID | Name | Evidence |
| GO:0003937 | IMP cyclohydrolase activity | IDA |
| GO:0004643 | phosphoribosylaminoimidazolecarboxamide formyltransferase activity | IDA |
| GO:0016740 | transferase activity | IEA |
| GO:0016787 | hydrolase activity | IEA |
| GO:0042803 | protein homodimerization activity | ISO |
| GO:0042803 | protein homodimerization activity | ISS |
| GeneCards | Atic |
| UniProt | O35567 |
| RGD | 70879 |
| Ensembl | ENSRNOG00000015511 |
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