QTRT1 queuine tRNA-ribosyltransferase 1 [Homo sapiens (human)]
| Gene Symbol | QTRT1 |
| Entrez Gene ID | 81890 |
| Full Name | queuine tRNA-ribosyltransferase 1 |
| Synonyms | FP3235, TGT |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
19 19p13.3 |
| Summary | tRNA-guanine transglycosylase (TGT; EC 2.4.2.29) synthesizes queuosine (Q), which is found in tRNAs that recognize NAU and NAC codons, encoding tyr, asn, asp, and his. Prokaryotic TGT is a single protein of 43 kD. In contrast, mammalian TGT appears to be a heterodimer consisting of a 60-kD subunit (USP14; MIM 607274) and a 43-kD catalytic subunit (QTRT1) (Deshpande and Katze, 2001 [PubMed 11255023]).[supplied by OMIM]. |
| Disorder | MIM: 609615 |
| mRNA | NM_031209, 221218971 |
| Protein | NP_112486, 13654276 |
| Product | queuine tRNA-ribosyltransferase |
| RefSeq Status | VALIDATED |
| Homo sapiens (human) | QTRT1 | NP_112486.1 |
| Pan troglodytes (chimpanzee) | QTRT1 | XP_512381.1 |
| Canis lupus familiaris (dog) | QTRT1 | XP_854015.1 |
| Bos taurus (cattle) | QTRT1 | XP_581789.2 |
| Mus musculus (house mouse) | Qtrt1 | NP_068688.1 |
| Rattus norvegicus (Norway rat) | Qtrt1 | NP_071586.1 |
| Danio rerio (zebrafish) | qtrt1 | NP_957304.1 |
| Drosophila melanogaster (fruit fly) | Tgt | NP_608585.1 |
| Caenorhabditis elegans | tgt-1 | NP_502268.1 |
| ID | Name | Evidence |
| GO:0006400 | tRNA modification | TAS |
| GO:0008616 | queuosine biosynthetic process | ISS |
| GO:0008616 | queuosine biosynthetic process | NAS |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005737 | cytoplasm | IEA |
| GO:0005739 | mitochondrion | IEA |
| GO:0005840 | ribosome | NAS |
Function
| ID | Name | Evidence |
| GO:0008479 | queuine tRNA-ribosyltransferase activity | ISS |
| GO:0008479 | queuine tRNA-ribosyltransferase activity | TAS |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA |
| GO:0046872 | metal ion binding | IEA |
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