HIST1H2BE histone cluster 1, H2be [Homo sapiens (human)]
| Gene Symbol | HIST1H2BE |
| Entrez Gene ID | 8344 |
| Full Name | histone cluster 1, H2be |
| Synonyms | H2B.h, H2B/a, H2B/g, H2B/h, H2B/k, H2B/l, H2BFH, H2BFN, dJ221C16.8 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
6 6p21.3 |
| Summary | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq]. |
| Disorder | MIM: 602805 |
| mRNA | NM_003523, 21396483 |
| Protein | NP_003514, 21396484 |
| Product | histone H2B type 1-C/E/F/G/I |
| RefSeq Status | REVIEWED |
| hsa05322 | Systemic lupus erythematosus |
Reactome
| REACT_2232 | RNA Polymerase I Promoter Opening |
| REACT_7970 | Telomere Maintenance |
| REACT_22186 | Deposition of New CENPA-containing Nucleosomes at the Centromere |
| REACT_1788 | Transcription |
| REACT_1974 | RNA Polymerase I Promoter Clearance |
| REACT_7963 | Packaging Of Telomere Ends |
| REACT_2204 | RNA Polymerase I Chain Elongation |
| REACT_22172 | Chromosome Maintenance |
| REACT_21352 | RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| REACT_22344 | Nucleosome assembly |
| REACT_1309 | RNA Polymerase I Transcription |
| Homo sapiens (human) | HIST1H2BG | NP_003509.1 |
| Homo sapiens (human) | HIST2H2BE | NP_003519.1 |
| Homo sapiens (human) | HIST1H2BI | NP_003516.1 |
| Homo sapiens (human) | HIST1H2BC | NP_003517.2 |
| Homo sapiens (human) | HIST1H2BF | NP_003513.1 |
| Homo sapiens (human) | HIST1H2BE | NP_003514.2 |
| Pan troglodytes (chimpanzee) | LOC471902 | XP_527280.2 |
| Canis lupus familiaris (dog) | LOC608682 | XP_859568.1 |
| Canis lupus familiaris (dog) | LOC483169 | XP_540287.1 |
| Canis lupus familiaris (dog) | LOC483173 | XP_540291.1 |
| Canis lupus familiaris (dog) | LOC483170 | XP_540288.1 |
| Canis lupus familiaris (dog) | LOC488267 | XP_545389.1 |
| Canis lupus familiaris (dog) | LOC478743 | XP_848229.1 |
| Canis lupus familiaris (dog) | LOC488276 | XP_545398.2 |
| Canis lupus familiaris (dog) | LOC488296 | XP_545418.1 |
| Canis lupus familiaris (dog) | LOC611126 | XP_853860.1 |
| Canis lupus familiaris (dog) | LOC611465 | XP_854227.1 |
| Canis lupus familiaris (dog) | LOC611482 | XP_854244.1 |
| Bos taurus (cattle) | LOC529646 | XP_608099.1 |
| Mus musculus (house mouse) | Hist1h2bn | NP_835508.1 |
| Mus musculus (house mouse) | Hist1h2bk | NP_783596.1 |
| Mus musculus (house mouse) | Hist1h2bl | NP_835506.1 |
| Mus musculus (house mouse) | Hist1h2bf | NP_835502.1 |
| Mus musculus (house mouse) | Hist1h2bj | NP_835505.1 |
| Rattus norvegicus (Norway rat) | Hist1h2bf | XP_225384.1 |
| Gallus gallus (chicken) | H2B-V | XP_416197.2 |
| Gallus gallus (chicken) | LOC769845 | XP_001232871.1 |
| Gallus gallus (chicken) | LOC770267 | XP_001233337.1 |
| Gallus gallus (chicken) | LOC769973 | XP_001232985.1 |
| Gallus gallus (chicken) | LOC770188 | XP_001233227.1 |
| Gallus gallus (chicken) | H2B-VII | XP_416196.2 |
| Danio rerio (zebrafish) | hist2h2l | NP_956411.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33910 | NP_001027283.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG17949 | NP_724342.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33908 | NP_001027287.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33906 | NP_001027291.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33904 | NP_001027296.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33902 | NP_001027300.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33900 | NP_001027305.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33898 | NP_001027310.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33896 | NP_001027315.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33894 | NP_001027320.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33892 | NP_001027325.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33890 | NP_001027330.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33888 | NP_001027335.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33886 | NP_001027340.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33884 | NP_001027345.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33882 | NP_001027350.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33880 | NP_001027355.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33878 | NP_001027360.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33876 | NP_001027365.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33874 | NP_001027370.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33872 | NP_001027375.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33870 | NP_001027380.1 |
| Drosophila melanogaster (fruit fly) | His2B:CG33868 | NP_001027385.1 |
| Arabidopsis thaliana (thale cress) | HTB2 | NP_197679.1 |
| Arabidopsis thaliana (thale cress) | HTB1 | NP_172258.1 |
| Arabidopsis thaliana (thale cress) | HTB9 | NP_190184.1 |
| Arabidopsis thaliana (thale cress) | AT2G28720 | NP_180440.1 |
| Arabidopsis thaliana (thale cress) | HTB4 | NP_200799.1 |
| Arabidopsis thaliana (thale cress) | HTB11 | NP_190189.1 |
| GeneCards | HIST1H2BE |
| MIM | 602805 |
| Ensembl | ENSG00000197697 |
| HGNC | 4753 |
| HPRD | 11901 |
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