HIST1H4D histone cluster 1, H4d [Homo sapiens (human)]
| Gene Symbol | HIST1H4D |
| Entrez Gene ID | 8360 |
| Full Name | histone cluster 1, H4d |
| Synonyms | H4/b, H4FB, dJ221C16.9 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
6 6p21.3 |
| Summary | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq]. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: 602823 |
| hsa05322 | Systemic lupus erythematosus |
WikiPathways
| WP619 | Type II interferon signaling (IFNG) |
Pathway Interaction Database
| hdac_classiii_pathway | Signaling events mediated by HDAC Class III |
Reactome
| REACT_1974 | RNA Polymerase I Promoter Clearance |
| REACT_22186 | Deposition of New CENPA-containing Nucleosomes at the Centromere |
| REACT_22344 | Nucleosome assembly |
| REACT_1309 | RNA Polymerase I Transcription |
| REACT_22172 | Chromosome Maintenance |
| REACT_21352 | RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| REACT_2204 | RNA Polymerase I Chain Elongation |
| REACT_7963 | Packaging Of Telomere Ends |
| REACT_2232 | RNA Polymerase I Promoter Opening |
| REACT_7970 | Telomere Maintenance |
| REACT_1788 | Transcription |
| Homo sapiens (human) | HIST1H4F | NP_003531.1 |
| Homo sapiens (human) | HIST2H4B | NP_001029249.1 |
| Homo sapiens (human) | HIST1H4J | NP_068803.1 |
| Homo sapiens (human) | HIST4H4 | NP_778224.1 |
| Homo sapiens (human) | HIST1H4K | NP_003532.1 |
| Homo sapiens (human) | HIST1H4A | NP_003529.1 |
| Homo sapiens (human) | HIST1H4L | NP_003537.1 |
| Homo sapiens (human) | HIST1H4H | NP_003534.1 |
| Homo sapiens (human) | HIST2H4A | NP_003539.1 |
| Homo sapiens (human) | HIST1H4B | NP_003535.1 |
| Homo sapiens (human) | HIST1H4E | NP_003536.1 |
| Homo sapiens (human) | HIST1H4C | NP_003533.1 |
| Homo sapiens (human) | HIST1H4D | NP_003530.1 |
| Homo sapiens (human) | HIST1H4I | NP_003486.1 |
| Pan troglodytes (chimpanzee) | LOC735611 | XP_001134995.1 |
| Pan troglodytes (chimpanzee) | LOC465305 | XP_520759.2 |
| Pan troglodytes (chimpanzee) | LOC736707 | XP_001138202.1 |
| Pan troglodytes (chimpanzee) | LOC457262 | XP_513765.1 |
| Pan troglodytes (chimpanzee) | LOC748532 | XP_001172749.1 |
| Pan troglodytes (chimpanzee) | LOC462507 | XP_518300.2 |
| Pan troglodytes (chimpanzee) | LOC748540 | XP_001172760.1 |
| Pan troglodytes (chimpanzee) | LOC472228 | XP_527602.1 |
| Pan troglodytes (chimpanzee) | LOC748545 | XP_001172771.1 |
| Pan troglodytes (chimpanzee) | LOC748525 | XP_001172736.1 |
| Pan troglodytes (chimpanzee) | LOC748513 | XP_001172726.1 |
| Canis lupus familiaris (dog) | LOC611513 | XP_854281.1 |
| Bos taurus (cattle) | LOC525863 | XP_604220.1 |
| Rattus norvegicus (Norway rat) | LOC679840 | XP_001054684.1 |
| Gallus gallus (chicken) | LOC417946 | NP_001032934.1 |
| Gallus gallus (chicken) | H4-VII | NP_001032932.1 |
| Gallus gallus (chicken) | LOC770005 | XP_001233009.1 |
| Gallus gallus (chicken) | LOC770142 | XP_001233180.1 |
| Gallus gallus (chicken) | LOC770079 | XP_001233095.1 |
| Gallus gallus (chicken) | LOC427884 | XP_425458.2 |
| Danio rerio (zebrafish) | zgc:153409 | NP_001070058.1 |
| Drosophila melanogaster (fruit fly) | His4:CG33881 | NP_001027352.1 |
| Drosophila melanogaster (fruit fly) | His4:CG33869 | NP_001027382.1 |
| Drosophila melanogaster (fruit fly) | His4:CG33879 | NP_001027357.1 |
| Drosophila melanogaster (fruit fly) | His4:CG33877 | NP_001027362.1 |
| Arabidopsis thaliana (thale cress) | AT5G59690 | NP_568911.1 |
| Arabidopsis thaliana (thale cress) | HIS4 | NP_180441.1 |
| Arabidopsis thaliana (thale cress) | AT5G59970 | NP_568918.1 |
| Arabidopsis thaliana (thale cress) | AT3G45930 | NP_190179.1 |
| Arabidopsis thaliana (thale cress) | AT3G46320 | NP_850660.1 |
| Arabidopsis thaliana (thale cress) | AT3G53730 | NP_190941.1 |
| Arabidopsis thaliana (thale cress) | AT1G07660 | NP_563793.1 |
| Arabidopsis thaliana (thale cress) | AT1G07820 | NP_850939.1 |
| GeneCards | HIST1H4D |
| MIM | 602823 |
| Ensembl | ENSG00000188987 |
| HGNC | 4782 |
| HPRD | 11914 |
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