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MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001013836 Homo sapiens MAD1 mitotic arrest deficient-like 1 (yeast) (MAD1L1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
NM_001013837 Homo sapiens MAD1 mitotic arrest deficient-like 1 (yeast) (MAD1L1), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
NM_003550 Homo sapiens MAD1 mitotic arrest deficient-like 1 (yeast) (MAD1L1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
XM_005249876 PREDICTED: Homo sapiens MAD1 mitotic arrest deficient-like 1 (yeast) (MAD1L1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005249877 PREDICTED: Homo sapiens MAD1 mitotic arrest deficient-like 1 (yeast) (MAD1L1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005249878 PREDICTED: Homo sapiens MAD1 mitotic arrest deficient-like 1 (yeast) (MAD1L1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006715788 PREDICTED: Homo sapiens MAD1 mitotic arrest deficient-like 1 (yeast) (MAD1L1), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol MAD1L1
Entrez Gene ID 8379
Full Name MAD1 mitotic arrest deficient-like 1 (yeast)
Synonyms MAD1, PIG9, TP53I9, TXBP181
General protein information
Preferred Names
mitotic spindle assembly checkpoint protein MAD1
Names
mitotic spindle assembly checkpoint protein MAD1
MAD1-like protein 1
tax-binding protein 181
tumor protein p53 inducible protein 9
mitotic checkpoint MAD1 protein homolog
mitotic arrest deficient 1-like protein 1
mitotic-arrest deficient 1, yeast, homolog-like 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7p22

Summary MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 602686

Lymphoma, somatic (3); Prostate cancer, somatic, 176807 (3)

mRNA Protein Product Sequence Price Select
NM_001013836, 62243368 NP_001013858, 62243369 mitotic spindle assembly checkpoint protein MAD1 ORF Sequence $490.00
NM_001013837, 62243373 NP_001013859, 62243374 mitotic spindle assembly checkpoint protein MAD1 ORF Sequence $490.00
NM_003550, 62243331 NP_003541, 62243332 mitotic spindle assembly checkpoint protein MAD1 ORF Sequence $490.00
XM_005249876, 530385041 XP_005249933, 530385042 mitotic spindle assembly checkpoint protein MAD1 isoform X1 ORF Sequence $700.00
XM_005249877, 530385043 XP_005249934, 530385044 mitotic spindle assembly checkpoint protein MAD1 isoform X2 ORF Sequence $700.00
XM_005249878, 530385045 XP_005249935, 530385046 mitotic spindle assembly checkpoint protein MAD1 isoform X3 ORF Sequence $700.00
XM_006715788, 578813661 XP_006715851, 578813662 mitotic spindle assembly checkpoint protein MAD1 isoform X4 ORF Sequence $700.00
KEGG
hsa04110Cell cycle
hsa04914Progesterone-mediated oocyte maturation
hsa05203Viral carcinogenesis
WikiPathways
WP179Cell cycle
Pathway Interaction Database
cmyb_pathwayC-MYB transcription factor network
Reactome
REACT_152Cell Cycle, Mitotic
REACT_795Amplification of signal from the kinetochores
REACT_2137Mitotic Spindle Checkpoint
REACT_1538Cell Cycle Checkpoints
REACT_682Mitotic Prometaphase
REACT_491Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
REACT_910M Phase
REACT_1275Mitotic Anaphase
REACT_115566Cell Cycle
REACT_150425Resolution of Sister Chromatid Cohesion
REACT_150314Mitotic Metaphase and Anaphase
REACT_150471Separation of Sister Chromatids
Homo sapiens (human)MAD1L1NP_001013858.1
Pan troglodytes (chimpanzee)MAD1L1XP_518933.2
Macaca mulatta (Rhesus monkey)MAD1L1XP_001102100.1
Canis lupus familiaris (dog)MAD1L1XP_852066.2
Bos taurus (cattle)MAD1L1NP_001095514.1
Mus musculus (house mouse)Mad1l1NP_034882.2
Rattus norvegicus (Norway rat)Mad1l1NP_001102857.1
Gallus gallus (chicken)MAD1L1XP_004945193.1
Danio rerio (zebrafish)mad1l1NP_957206.2
Drosophila melanogaster (fruit fly)Mad1NP_610477.2
Xenopus (Silurana) tropicalis (western clawed frog)mad1l1NP_001006927.1
Process
IDNameEvidence
GO:0000089mitotic metaphaseNAS
GO:0000090mitotic anaphaseNAS
GO:0000093mitotic telophaseNAS
GO:0000278mitotic cell cycleTAS
GO:0007067mitotic nuclear divisionIEA
GO:0007093mitotic cell cycle checkpointNAS
GO:0007094mitotic spindle assembly checkpointTAS
GO:0090235regulation of metaphase plate congressionIDA
Component
IDNameEvidence
GO:0000776kinetochoreIDA
GO:0000776kinetochoreIDA
GO:0000777condensed chromosome kinetochoreIEA
GO:0005634nucleusIDA
GO:0005643nuclear poreIDA
GO:0005737cytoplasmIDA
GO:0005813centrosomeNAS
GO:0005819spindleNAS
GO:0005829cytosolTAS
GO:0015629actin cytoskeletonIDA
GO:0072686mitotic spindleIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GeneCards MAD1L1
PDB 1GO4, 4DZO
UniProt Q9Y6D9
Vega OTTHUMG00000151493
MIM 602686
Ensembl ENSG00000002822
HGNC 6762
HPRD 04065

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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