PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) [Homo sapiens (human)]
| Gene Symbol | PLA2G6 |
| Entrez Gene ID | 8398 |
| Full Name | phospholipase A2, group VI (cytosolic, calcium-independent) |
| Synonyms | CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, iPLA2 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
22 22q13.1 |
| Summary | The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq]. |
| Disorder | MIM: 603604 Infantile neuroaxonal dystrophy 1, 256600 (3); Neurodegeneration |
| mRNA | NM_003560, 52486193 |
| Protein | NP_003551, 52486194 |
| Product | 85 kDa calcium-independent phospholipase A2 isoform a |
| RefSeq Status | REVIEWED |
| mRNA | NM_001004426, 52486250 |
| Protein | NP_001004426, 52486251 |
| Product | 85 kDa calcium-independent phospholipase A2 isoform b |
| RefSeq Status | REVIEWED |
| mRNA | NM_001199562, 313760591 |
| Protein | NP_001186491, 313760592 |
| Product | 85 kDa calcium-independent phospholipase A2 isoform b |
| RefSeq Status | REVIEWED |
| hsa04270 | Vascular smooth muscle contraction |
| hsa00590 | Arachidonic acid metabolism |
| hsa04664 | Fc epsilon RI signaling pathway |
| hsa00564 | Glycerophospholipid metabolism |
| hsa04912 | GnRH signaling pathway |
| hsa04010 | MAPK signaling pathway |
| hsa05145 | Toxoplasmosis |
| hsa04730 | Long-term depression |
| hsa01100 | Metabolic pathways |
| hsa04972 | Pancreatic secretion |
| hsa04975 | Fat digestion and absorption |
| hsa00592 | alpha-Linolenic acid metabolism |
| hsa00591 | Linoleic acid metabolism |
| hsa00565 | Ether lipid metabolism |
| hsa04370 | VEGF signaling pathway |
| hsa04666 | Fc gamma R-mediated phagocytosis |
WikiPathways
| WP167 | Eicosanoid Synthesis |
BIOCYC
| HUMAN_LIPASYN-PWY | phospholipases |
| Homo sapiens (human) | PLA2G6 | NP_003551.2 |
| Canis lupus familiaris (dog) | PLA2G6 | XP_850251.1 |
| Bos taurus (cattle) | PLA2G6 | XP_001251755.2 |
| Mus musculus (house mouse) | Pla2g6 | NP_058611.1 |
| Rattus norvegicus (Norway rat) | Pla2g6 | NP_001005560.1 |
| Gallus gallus (chicken) | PLA2G6 | XP_416265.2 |
| Danio rerio (zebrafish) | pla2g6 | NP_998262.1 |
| Drosophila melanogaster (fruit fly) | iPLA2-VIA | NP_729567.2 |
| Caenorhabditis elegans | W07A8.2 | NP_001123029.1 |
| Caenorhabditis elegans | F47A4.5 | NP_509647.1 |
| ID | Name | Evidence |
| GO:0008152 | metabolic process | IEA |
| GO:0008219 | cell death | IEA |
| GO:0016042 | lipid catabolic process | IEA |
| GO:0032049 | cardiolipin biosynthetic process | IMP |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IDA |
| GO:0005813 | centrosome | IDA |
| GO:0016020 | membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0004623 | phospholipase A2 activity | TAS |
| GO:0016787 | hydrolase activity | IEA |
| GO:0047499 | calcium-independent phospholipase A2 activity | IEA |
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