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PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001004426 Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001199562 Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_003560 Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol PLA2G6
Entrez Gene ID 8398
Full Name phospholipase A2, group VI (cytosolic, calcium-independent)
Synonyms CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, iPLA2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q13.1

Summary The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010].
Disorder

MIM: 603604

Infantile neuroaxonal dystrophy 1, 256600 (3); Neurodegeneration

mRNA Protein Product Sequence Price Select
NM_001004426, 52486250 NP_001004426, 52486251 85/88 kDa calcium-independent phospholipase A2 isoform b ORF Sequence $700.00
NM_001199562, 313760591 NP_001186491, 313760592 85/88 kDa calcium-independent phospholipase A2 isoform b ORF Sequence $700.00
NM_003560, 52486193 NP_003551, 52486194 85/88 kDa calcium-independent phospholipase A2 isoform a ORF Sequence $750.00
KEGG
hsa04666Fc gamma R-mediated phagocytosis
hsa00591Linoleic acid metabolism
hsa00565Ether lipid metabolism
hsa00590Arachidonic acid metabolism
hsa00564Glycerophospholipid metabolism
hsa04270Vascular smooth muscle contraction
hsa00592alpha-Linolenic acid metabolism
WikiPathways
WP167Eicosanoid Synthesis
BIOCYC
HUMAN_LIPASYN-PWYphospholipases
Reactome
REACT_121006Acyl chain remodeling of CL
REACT_121401Glycerophospholipid biosynthesis
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_121369Acyl chain remodelling of PE
REACT_120870Phospholipid metabolism
REACT_120829Acyl chain remodelling of PC
Homo sapiens (human)PLA2G6NP_003551.2
Pan troglodytes (chimpanzee)PLA2G6XP_003317276.1
Macaca mulatta (Rhesus monkey)PLA2G6XP_002798434.1
Canis lupus familiaris (dog)PLA2G6XP_861095.1
Bos taurus (cattle)PLA2G6XP_002687969.2
Mus musculus (house mouse)Pla2g6NP_001185952.1
Rattus norvegicus (Norway rat)Pla2g6NP_001005560.1
Gallus gallus (chicken)PLA2G6NP_001124210.1
Danio rerio (zebrafish)pla2g6NP_998262.1
Drosophila melanogaster (fruit fly)iPLA2-VIANP_729567.2
Caenorhabditis elegansCELE_W07A8.2NP_001123029.1
Caenorhabditis elegansF47A4.5NP_509647.1
GeneCards PLA2G6
UniProt A8K460, O60733
MIM 603604
Ensembl ENSG00000184381
HGNC 9039
HPRD 04675

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
85/88 kDa calcium-independent phospholipase A2
Names
85/88 kDa calcium-independent phospholipase A2
GVI PLA2
iPLA2-beta
group VI phospholipase A2
calcium-independent phospholipase A2
85 kDa calcium-independent phospholipase A2
patatin-like phospholipase domain containing 9
cytosolic, calcium-independent phospholipase A2
neurodegeneration with brain iron accumulation 2
patatin-like phospholipase domain-containing protein 9
intracellular membrane-associated calcium-independent phospholipase A2 beta
NP_001004426.1
NP_001186491.1
NP_003551.2

Interactant



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