• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001004426 Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001199562 Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_003560 Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005261764 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005261765 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005261766 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005261771 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006724332 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X13, mRNA. GenEZ ORF Cloning On-demand $899.00 20

*Business Day

Related Services

Gene Symbol PLA2G6
Entrez Gene ID 8398
Full Name phospholipase A2, group VI (cytosolic, calcium-independent)
Synonyms CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, iPLA2, iPLA2beta
General protein information
Preferred Names
85/88 kDa calcium-independent phospholipase A2
Names
85/88 kDa calcium-independent phospholipase A2
GVI PLA2
iPLA2-beta
group VI phospholipase A2
calcium-independent phospholipase A2
85 kDa calcium-independent phospholipase A2
patatin-like phospholipase domain containing 9
cytosolic, calcium-independent phospholipase A2
neurodegeneration with brain iron accumulation 2
patatin-like phospholipase domain-containing protein 9
intracellular membrane-associated calcium-independent phospholipase A2 beta
NP_001004426.1
NP_001186491.1
NP_003551.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q13.1

Summary The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010].
Disorder

MIM: 603604

Infantile neuroaxonal dystrophy 1, 256600 (3); Neurodegeneration

mRNA Protein Product Sequence Price Select
NM_001004426, 52486250 NP_001004426, 52486251 85/88 kDa calcium-independent phospholipase A2 isoform b ORF Sequence $700.00
NM_001199562, 313760591 NP_001186491, 313760592 85/88 kDa calcium-independent phospholipase A2 isoform b ORF Sequence $700.00
NM_003560, 52486193 NP_003551, 52486194 85/88 kDa calcium-independent phospholipase A2 isoform a ORF Sequence $750.00
XM_005261764, 530420421 XP_005261821, 530420422 85/88 kDa calcium-independent phospholipase A2 isoform X1 ORF Sequence $750.00
XM_005261765, 530420423 XP_005261822, 530420424 85/88 kDa calcium-independent phospholipase A2 isoform X2 ORF Sequence $750.00
XM_005261766, 530420425 XP_005261823, 530420426 85/88 kDa calcium-independent phospholipase A2 isoform X3 ORF Sequence $750.00
XM_005261771, 578837425 XP_005261828, 530420439 85/88 kDa calcium-independent phospholipase A2 isoform X8 ORF Sequence $550.00
XM_006724332, 578837421 XP_006724395, 578837422 85/88 kDa calcium-independent phospholipase A2 isoform X13 ORF Sequence $750.00
KEGG
hsa00565Ether lipid metabolism
hsa00591Linoleic acid metabolism
hsa00590Arachidonic acid metabolism
hsa00592alpha-Linolenic acid metabolism
hsa00564Glycerophospholipid metabolism
hsa04270Vascular smooth muscle contraction
hsa04666Fc gamma R-mediated phagocytosis
hsa04750Inflammatory mediator regulation of TRP channels
hsa04014Ras signaling pathway
WikiPathways
WP167Eicosanoid Synthesis
WP2431Spinal Cord Injury
Reactome
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
REACT_121369Acyl chain remodelling of PE
REACT_121401Glycerophospholipid biosynthesis
REACT_120870Phospholipid metabolism
REACT_120829Acyl chain remodelling of PC
REACT_121006Acyl chain remodeling of CL
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_160158Role of phospholipids in phagocytosis
Homo sapiens (human)PLA2G6NP_003551.2
Pan troglodytes (chimpanzee)PLA2G6XP_003317276.1
Macaca mulatta (Rhesus monkey)PLA2G6XP_002798434.1
Canis lupus familiaris (dog)PLA2G6XP_861095.2
Bos taurus (cattle)PLA2G6XP_002687969.2
Mus musculus (house mouse)Pla2g6NP_001185952.1
Rattus norvegicus (Norway rat)Pla2g6NP_001005560.1
Gallus gallus (chicken)PLA2G6NP_001124210.1
Danio rerio (zebrafish)pla2g6NP_998262.1
Drosophila melanogaster (fruit fly)iPLA2-VIANP_648366.2
Caenorhabditis elegansCELE_W07A8.2NP_508000.1
Caenorhabditis elegansF47A4.5NP_509647.1
Xenopus (Silurana) tropicalis (western clawed frog)pla2g6NP_001072661.1
Process
IDNameEvidence
GO:0001934positive regulation of protein phosphorylationIEA
GO:0006644phospholipid metabolic processTAS
GO:0006935chemotaxisIEA
GO:0007204positive regulation of cytosolic calcium ion concentrationIEA
GO:0007613memoryIEA
GO:0008219cell deathIEA
GO:0014832urinary bladder smooth muscle contractionIEA
GO:0016042lipid catabolic processIEA
GO:0032049cardiolipin biosynthetic processIMP
GO:0034976response to endoplasmic reticulum stressIEA
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulusIEA
GO:0035965cardiolipin acyl-chain remodelingTAS
GO:0036151phosphatidylcholine acyl-chain remodelingTAS
GO:0036152phosphatidylethanolamine acyl-chain remodelingTAS
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTAS
GO:0044281small molecule metabolic processTAS
GO:0045087innate immune responseTAS
GO:0045909positive regulation of vasodilationIEA
GO:0045921positive regulation of exocytosisIEA
GO:0046474glycerophospholipid biosynthetic processTAS
GO:0051967negative regulation of synaptic transmission, glutamatergicIEA
GO:0060135maternal process involved in female pregnancyIEA
GO:0090037positive regulation of protein kinase C signalingIEA
GO:0090200positive regulation of release of cytochrome c from mitochondriaIEA
GO:0090238positive regulation of arachidonic acid secretionIEA
GO:1901339regulation of store-operated calcium channel activityIEA
GO:2000304positive regulation of ceramide biosynthetic processIEA
Component
IDNameEvidence
GO:0005739mitochondrionIEA
GO:0005829cytosolTAS
GO:0016020membraneIEA
Function
IDNameEvidence
GO:0004623phospholipase A2 activityTAS
GO:0005516calmodulin bindingIEA
GO:0043008ATP-dependent protein bindingIEA
GO:0047499calcium-independent phospholipase A2 activityIEA
GeneCards PLA2G6
UniProt A8K460, O60733
Vega OTTHUMG00000151246
MIM 603604
Ensembl ENSG00000184381
HGNC 9039
HPRD 04675

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PLA2G6 gene?

The PLA2G6 gene provides instructions for making a type of enzyme called an A2 phospholipase. This type of enzyme is involved in breaking down (metabolizing) fats called phospholipids. Phospholipid metabolism is important for many body processes, including helping to maintain the integrity of the cell membrane. Specifically, the A2 phospholipase produced from the PLA2G6 gene, sometimes called PLA2 group VI, helps to regulate the levels of a compound called phosphatidylcholine, which is abundant in the cell membrane.

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.