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PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25784 NM_001004426 Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $329.00
OHu25843 NM_003560 Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $329.00
OHu25784 NM_001199562 Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $329.00
OHu25843 XM_005261764 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $329.00
OHu25843 XM_005261765 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $329.00
OHu25843 XM_005261766 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $329.00
OHu25843 XM_006724332 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X13, mRNA. pcDNA3.1+-DYK On-demand 12-14 $329.00
OHu53705 XM_005261771 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X8, mRNA. pcDNA3.1+-DYK On-demand 7-9 $269.00
OHu25784C NM_001004426 Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 2, mRNA. Customized vector On-demand 12-14 $329.00
OHu25843C NM_003560 Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 1, mRNA. Customized vector On-demand 12-14 $329.00
OHu25784C NM_001199562 Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant 3, mRNA. Customized vector On-demand 12-14 $329.00
OHu25843C XM_005261764 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00
OHu25843C XM_005261765 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00
OHu25843C XM_005261766 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X3, mRNA. Customized vector On-demand 12-14 $329.00
OHu25843C XM_006724332 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X13, mRNA. Customized vector On-demand 12-14 $329.00
OHu53705C XM_005261771 PREDICTED: Homo sapiens phospholipase A2, group VI (cytosolic, calcium-independent) (PLA2G6), transcript variant X8, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol PLA2G6
Entrez Gene ID 8398
Full Name phospholipase A2, group VI (cytosolic, calcium-independent)
Synonyms CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, iPLA2, iPLA2beta
General protein information
Preferred Names
85/88 kDa calcium-independent phospholipase A2
Names
85/88 kDa calcium-independent phospholipase A2
GVI PLA2
iPLA2-beta
group VI phospholipase A2
calcium-independent phospholipase A2
85 kDa calcium-independent phospholipase A2
patatin-like phospholipase domain containing 9
cytosolic, calcium-independent phospholipase A2
neurodegeneration with brain iron accumulation 2
patatin-like phospholipase domain-containing protein 9
intracellular membrane-associated calcium-independent phospholipase A2 beta
NP_001004426.1
NP_001186491.1
NP_003551.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q13.1

Summary The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010].
Disorder

MIM: 603604

Infantile neuroaxonal dystrophy 1, 256600 (3); Neurodegeneration

mRNA Protein Product Sequence Price Select
NM_001004426, 52486250 NP_001004426, 52486251 85/88 kDa calcium-independent phospholipase A2 isoform b ORF Sequence $700.00
NM_001199562, 313760591 NP_001186491, 313760592 85/88 kDa calcium-independent phospholipase A2 isoform b ORF Sequence $700.00
NM_003560, 52486193 NP_003551, 52486194 85/88 kDa calcium-independent phospholipase A2 isoform a ORF Sequence $750.00
XM_005261764, 530420421 XP_005261821, 530420422 85/88 kDa calcium-independent phospholipase A2 isoform X1 ORF Sequence $750.00
XM_005261765, 530420423 XP_005261822, 530420424 85/88 kDa calcium-independent phospholipase A2 isoform X2 ORF Sequence $750.00
XM_005261766, 530420425 XP_005261823, 530420426 85/88 kDa calcium-independent phospholipase A2 isoform X3 ORF Sequence $750.00
XM_005261771, 578837425 XP_005261828, 530420439 85/88 kDa calcium-independent phospholipase A2 isoform X8 ORF Sequence $550.00
XM_006724332, 578837421 XP_006724395, 578837422 85/88 kDa calcium-independent phospholipase A2 isoform X13 ORF Sequence $750.00
KEGG
hsa00565Ether lipid metabolism
hsa00591Linoleic acid metabolism
hsa00590Arachidonic acid metabolism
hsa00592alpha-Linolenic acid metabolism
hsa00564Glycerophospholipid metabolism
hsa04270Vascular smooth muscle contraction
hsa04666Fc gamma R-mediated phagocytosis
hsa04750Inflammatory mediator regulation of TRP channels
hsa04014Ras signaling pathway
WikiPathways
WP167Eicosanoid Synthesis
WP2431Spinal Cord Injury
Reactome
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
REACT_121369Acyl chain remodelling of PE
REACT_121401Glycerophospholipid biosynthesis
REACT_120870Phospholipid metabolism
REACT_120829Acyl chain remodelling of PC
REACT_121006Acyl chain remodeling of CL
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_160158Role of phospholipids in phagocytosis
Homo sapiens (human)PLA2G6NP_003551.2
Pan troglodytes (chimpanzee)PLA2G6XP_003317276.1
Macaca mulatta (Rhesus monkey)PLA2G6XP_002798434.1
Canis lupus familiaris (dog)PLA2G6XP_861095.2
Bos taurus (cattle)PLA2G6XP_002687969.2
Mus musculus (house mouse)Pla2g6NP_001185952.1
Rattus norvegicus (Norway rat)Pla2g6NP_001005560.1
Gallus gallus (chicken)PLA2G6NP_001124210.1
Danio rerio (zebrafish)pla2g6NP_998262.1
Drosophila melanogaster (fruit fly)iPLA2-VIANP_648366.2
Caenorhabditis elegansCELE_W07A8.2NP_508000.1
Caenorhabditis elegansF47A4.5NP_509647.1
Xenopus (Silurana) tropicalis (western clawed frog)pla2g6NP_001072661.1
Process
IDNameEvidence
GO:0001934positive regulation of protein phosphorylationIEA
GO:0006644phospholipid metabolic processTAS
GO:0006935chemotaxisIEA
GO:0007204positive regulation of cytosolic calcium ion concentrationIEA
GO:0007613memoryIEA
GO:0008219cell deathIEA
GO:0014832urinary bladder smooth muscle contractionIEA
GO:0016042lipid catabolic processIEA
GO:0032049cardiolipin biosynthetic processIMP
GO:0034976response to endoplasmic reticulum stressIEA
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulusIEA
GO:0035965cardiolipin acyl-chain remodelingTAS
GO:0036151phosphatidylcholine acyl-chain remodelingTAS
GO:0036152phosphatidylethanolamine acyl-chain remodelingTAS
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTAS
GO:0044281small molecule metabolic processTAS
GO:0045087innate immune responseTAS
GO:0045909positive regulation of vasodilationIEA
GO:0045921positive regulation of exocytosisIEA
GO:0046474glycerophospholipid biosynthetic processTAS
GO:0051967negative regulation of synaptic transmission, glutamatergicIEA
GO:0060135maternal process involved in female pregnancyIEA
GO:0090037positive regulation of protein kinase C signalingIEA
GO:0090200positive regulation of release of cytochrome c from mitochondriaIEA
GO:0090238positive regulation of arachidonic acid secretionIEA
GO:1901339regulation of store-operated calcium channel activityIEA
GO:2000304positive regulation of ceramide biosynthetic processIEA
Component
IDNameEvidence
GO:0005739mitochondrionIEA
GO:0005829cytosolTAS
GO:0016020membraneIEA
Function
IDNameEvidence
GO:0004623phospholipase A2 activityTAS
GO:0005516calmodulin bindingIEA
GO:0043008ATP-dependent protein bindingIEA
GO:0047499calcium-independent phospholipase A2 activityIEA
GeneCards PLA2G6
UniProt A8K460, O60733
Vega OTTHUMG00000151246
MIM 603604
Ensembl ENSG00000184381
HGNC 9039
HPRD 04675

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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