Sequence in raw or FASTA format:
MAGT1 magnesium transporter 1 [Homo sapiens (human)]
|Entrez Gene ID||84061|
|Full Name||magnesium transporter 1|
|Synonyms||IAP, MRX95, OST3B, PRO0756, XMEN, bA217H1.1|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jan 2010].|
Mental retardation, X-linked 95, 300716 (3)
|REACT_17015||Metabolism of proteins|
|REACT_22161||Post-translational protein modification|
|REACT_22426||Asparagine N-linked glycosylation|
|Homo sapiens (human)||MAGT1||NP_115497.4|
|Macaca mulatta (Rhesus monkey)||LOC710098||XP_002806337.1|
|Canis lupus familiaris (dog)||MAGT1||XP_549095.3|
|Bos taurus (cattle)||MAGT1||NP_001231247.1|
|Mus musculus (house mouse)||Magt1||NP_001177338.1|
|Rattus norvegicus (Norway rat)||Magt1||NP_446398.1|
|Gallus gallus (chicken)||MAGT1||NP_001006435.1|
|Danio rerio (zebrafish)||magt1||NP_955994.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||magt1||XP_002931857.1|
|GO:0006487||protein N-linked glycosylation||NAS|
|GO:0015693||magnesium ion transport||IMP|
|GO:0018279||protein N-linked glycosylation via asparagine||TAS|
|GO:0043687||post-translational protein modification||TAS|
|GO:0044267||cellular protein metabolic process||TAS|
|GO:0005789||endoplasmic reticulum membrane||TAS|
|GO:0005887||integral component of plasma membrane||NAS|
|GO:0015095||magnesium ion transmembrane transporter activity||IMP|
What is the normal function of the MAGT1 gene?
The MAGT1 gene provides instructions for making a protein called a magnesium transporter, which moves charged atoms (ions) of magnesium (Mg2+) into certain immune system cells called T cells. T cells recognize foreign invaders, such as viruses, bacteria, and fungi, and are then turned on (activated) to attack these invaders in order to prevent infection and illness. Specifically, the magnesium transporter produced from the MAGT1 gene is active in CD8+ T cells, which are especially important in controlling viral infections such as the Epstein-Barr virus (EBV). These cells normally take in magnesium when they detect a foreign invader, and the magnesium is involved in activating the T cell's response.
Researchers suggest that magnesium transport may also be involved in the production of another type of T cell called helper T cells (CD4+ T cells) in a gland called the thymus. CD4+ T cells direct and assist the functions of the immune system by influencing the activities of other immune system cells.
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