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Sequence in raw or FASTA format:


Blast Method:


RNASEH2C ribonuclease H2, subunit C [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_032193 Homo sapiens ribonuclease H2, subunit C (RNASEH2C), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

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Gene Symbol RNASEH2C
Entrez Gene ID 84153
Full Name ribonuclease H2, subunit C
Synonyms AGS3, AYP1
General protein information
Preferred Names
ribonuclease H2 subunit C
ribonuclease H2 subunit C
RNase H2 subunit C
RNase H1 small subunit
ribonuclease HI subunit C
aicardi-Goutieres syndrome 3 protein
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008].

MIM: 610330

Aicardi-Goutieres syndrome 3, 610329 (3)

mRNA Protein Product Sequence Price Select
NM_032193, 113204623 NP_115569, 38176285 ribonuclease H2 subunit C ORF Sequence $159.00
hsa03030DNA replication
Homo sapiens (human)RNASEH2CNP_115569.2
Pan troglodytes (chimpanzee)RNASEH2CXP_508559.3
Macaca mulatta (Rhesus monkey)LOC701279XP_001089023.1
Macaca mulatta (Rhesus monkey)RNASEH2CXP_001085695.1
Canis lupus familiaris (dog)RNASEH2CXP_852826.1
Bos taurus (cattle)RNASEH2CNP_001039386.1
Mus musculus (house mouse)Rnaseh2cNP_080892.1
Rattus norvegicus (Norway rat)Rnaseh2cXP_002728902.1
GO:0006401RNA catabolic processIDA
GO:0032299ribonuclease H2 complexIDA
GeneCards RNASEH2C
UniProt Q8TDP1
Vega OTTHUMG00000166601
MIM 610330
Ensembl ENSG00000172922
HGNC 24116
HPRD 16531

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the RNASEH2C gene?

The RNASEH2C gene provides instructions for making one part (subunit) of a group of proteins called the RNase H2 complex. This complex is a ribonuclease, which means it is an enzyme that helps break down RNA, a chemical cousin of DNA. In particular, the RNase H2 complex helps break down molecules in which one strand of RNA is combined with one strand of DNA (RNA-DNA hybrids). These hybrids are formed during DNA copying (replication) and are found in all cells.

The RNase H2 complex is involved in DNA replication, error repair, and other cellular functions. Researchers believe that these additional functions may include helping to prevent inappropriate immune system activation.


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