Sequence in raw or FASTA format:
RNASEH2C ribonuclease H2, subunit C [Homo sapiens (human)]
|Entrez Gene ID||84153|
|Full Name||ribonuclease H2, subunit C|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008].|
Aicardi-Goutieres syndrome 3, 610329 (3)
|Homo sapiens (human)||RNASEH2C||NP_115569.2|
|Pan troglodytes (chimpanzee)||RNASEH2C||XP_508559.3|
|Macaca mulatta (Rhesus monkey)||LOC701279||XP_001089023.1|
|Macaca mulatta (Rhesus monkey)||RNASEH2C||XP_001085695.1|
|Canis lupus familiaris (dog)||RNASEH2C||XP_852826.1|
|Bos taurus (cattle)||RNASEH2C||NP_001039386.1|
|Mus musculus (house mouse)||Rnaseh2c||NP_080892.1|
|Rattus norvegicus (Norway rat)||Rnaseh2c||XP_002728902.1|
|GO:0006401||RNA catabolic process||IDA|
|GO:0032299||ribonuclease H2 complex||IDA|
What is the normal function of the RNASEH2C gene?
The RNASEH2C gene provides instructions for making one part (subunit) of a group of proteins called the RNase H2 complex. This complex is a ribonuclease, which means it is an enzyme that helps break down RNA, a chemical cousin of DNA. In particular, the RNase H2 complex helps break down molecules in which one strand of RNA is combined with one strand of DNA (RNA-DNA hybrids). These hybrids are formed during DNA copying (replication) and are found in all cells.
The RNase H2 complex is involved in DNA replication, error repair, and other cellular functions. Researchers believe that these additional functions may include helping to prevent inappropriate immune system activation.
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