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Sequence in raw or FASTA format:


Blast Method:


SLX4 SLX4 structure-specific endonuclease subunit [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18199D NM_032444 Homo sapiens SLX4 structure-specific endonuclease subunit (SLX4), mRNA. pcDNA3.1-C-(k)DYK On-demand 25 Starting from $99
OHu18199C NM_032444 Homo sapiens SLX4 structure-specific endonuclease subunit (SLX4), mRNA. Customized vector On-demand 25 Starting from $99

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Gene Symbol SLX4
Entrez Gene ID 84464
Full Name SLX4 structure-specific endonuclease subunit
Synonyms BTBD12, FANCP, MUS312
General protein information
Preferred Names
structure-specific endonuclease subunit SLX4
structure-specific endonuclease subunit SLX4
BTB (POZ) domain containing 12
BTB/POZ domain-containing protein 12
SLX4 structure-specific endonuclease subunit homolog
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011].

MIM: 613278

mRNA Protein Product Sequence Price Select
NM_032444, 63252862 NP_115820, 63252863 structure-specific endonuclease subunit SLX4 ORF Sequence $2500.00
hsa03460Fanconi anemia pathway
Homo sapiens (human)SLX4NP_115820.2
Pan troglodytes (chimpanzee)SLX4XP_510772.2
Macaca mulatta (Rhesus monkey)SLX4XP_001094220.2
Canis lupus familiaris (dog)SLX4XP_005621673.1
Bos taurus (cattle)SLX4XP_002697931.2
Mus musculus (house mouse)Slx4NP_803423.2
Rattus norvegicus (Norway rat)Slx4XP_006245897.1
Gallus gallus (chicken)SLX4XP_414962.4
GO:0000724double-strand break repair via homologous recombinationIMP
GO:0000737DNA catabolic process, endonucleolyticIDA
GO:0000737DNA catabolic process, endonucleolyticIEA
GO:0006260DNA replicationIEA
GO:0006281DNA repairIMP
GO:0006289nucleotide-excision repairIMP
GO:0010792DNA double-strand break processing involved in repair via single-strand annealingIMP
GO:0043085positive regulation of catalytic activityIDA
GO:0072429response to intra-S DNA damage checkpoint signalingIMP
GO:0000784nuclear chromosome, telomeric regionIDA
GO:0000790nuclear chromatinIDA
GO:0030054cell junctionIDA
GO:0033557Slx1-Slx4 complexIDA
GO:0048476Holliday junction resolvase complexIDA
GO:0070522ERCC4-ERCC1 complexIDA
GO:0005515protein bindingIPI
GO:0008047enzyme activator activityIDA
GO:0008821crossover junction endodeoxyribonuclease activityIDA
GO:00171085'-flap endonuclease activityIDA
GO:00482573'-flap endonuclease activityIDA
GeneCards SLX4
UniProt Q8IY92
Vega OTTHUMG00000074089
MIM 613278
Ensembl ENSG00000188827
HGNC 23845
HPRD 12537

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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