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PIGO phosphatidylinositol glycan anchor biosynthesis, class O [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001201484 Homo sapiens phosphatidylinositol glycan anchor biosynthesis, class O (PIGO), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
NM_032634 Homo sapiens phosphatidylinositol glycan anchor biosynthesis, class O (PIGO), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_152850 Homo sapiens phosphatidylinositol glycan anchor biosynthesis, class O (PIGO), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
XM_005251619 PREDICTED: Homo sapiens phosphatidylinositol glycan anchor biosynthesis, class O (PIGO), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol PIGO
Entrez Gene ID 84720
Full Name phosphatidylinositol glycan anchor biosynthesis, class O
Synonyms HPMRS2
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9p13.3

Summary This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
Disorder

MIM: 614730

mRNA Protein Product Sequence Price Select
NM_001201484, 319918881 NP_001188413, 319918882 GPI ethanolamine phosphate transferase 3 isoform 2 ORF Sequence $490.00
NM_032634, 319918879 NP_116023, 23397648 GPI ethanolamine phosphate transferase 3 isoform 1 ORF Sequence $1500.00
NM_152850, 319918880 NP_690577, 38045917 GPI ethanolamine phosphate transferase 3 isoform 2 ORF Sequence $490.00
XM_005251619, 530390223 XP_005251676, 530390224 GPI ethanolamine phosphate transferase 3 isoform X1 ORF Sequence $1500.00
KEGG
hsa00563Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Reactome
REACT_17015Metabolism of proteins
REACT_952Synthesis of glycosylphosphatidylinositol (GPI)
REACT_1853Post-translational modification: synthesis of GPI-anchored proteins
REACT_22161Post-translational protein modification
Homo sapiens (human)PIGONP_116023.2
Pan troglodytes (chimpanzee)PIGOXP_001165498.1
Macaca mulatta (Rhesus monkey)PIGOXP_001091501.1
Canis lupus familiaris (dog)PIGOXP_005626807.1
Bos taurus (cattle)PIGOXP_002689720.1
Mus musculus (house mouse)PigoNP_064419.2
Rattus norvegicus (Norway rat)PigoXP_233141.7
Gallus gallus (chicken)PIGOXP_004937176.1
Danio rerio (zebrafish)pigoXP_692445.3
Drosophila melanogaster (fruit fly)CG12263NP_611332.1
Caenorhabditis elegansC27A12.9NP_491750.3
Xenopus (Silurana) tropicalis (western clawed frog)pigoNP_001120383.1
Process
IDNameEvidence
GO:0006501C-terminal protein lipidationTAS
GO:0006506GPI anchor biosynthetic processISS
GO:0016254preassembly of GPI anchor in ER membraneTAS
GO:0043687post-translational protein modificationTAS
GO:0044267cellular protein metabolic processTAS
Component
IDNameEvidence
GO:0005789endoplasmic reticulum membraneISS
GO:0016020membraneIDA
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0003674molecular_functionND
GO:0016740transferase activityIEA
GeneCards PIGO
UniProt Q8TEQ8
Vega OTTHUMG00000019854
MIM 614730
Ensembl ENSG00000165282
HGNC 23215
HPRD 15134

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PIGO gene?

The PIGO gene provides instructions for making one part of an enzyme called GPI ethanolamine phosphate transfer 3 (GPI-ET3). The other part of the GPI-ET3 enzyme is produced from a gene called PIGF. The GPI-ET3 enzyme is involved in a series of steps that produce a molecule called a glycosylphosphosphatidylinositol (GPI) anchor. Specifically, this enzyme adds a molecule of ethanolamine phosphate to the end of the forming GPI anchor. This step takes place in the endoplasmic reticulum, which is a structure involved in protein processing and transport within cells. The complete GPI anchor attaches (binds) to various proteins in the endoplasmic reticulum; this process requires the ethanolamine phosphate at the end of the anchor. After the anchor and protein are bound, the anchor attaches itself to the outer surface of the cell membrane, ensuring that the protein will be available when it is needed.

Interactant

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