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RAD50 Rad50p [Saccharomyces cerevisiae S288c ]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OSi04399 NM_001183088 Saccharomyces cerevisiae S288c Rad50p (RAD50), mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OSi04399C NM_001183088 Saccharomyces cerevisiae S288c Rad50p (RAD50), mRNA. Customized vector On-demand 25 $1699.00

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Gene Symbol RAD50
Entrez Gene ID 855471
Full Name Rad50p
Synonyms
General protein information
Names
Rad50p
NP_014149.1
  • Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress
Gene Type protein-coding
Organism Saccharomyces cerevisiae S288c ()
Genome

XIV

Summary
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_001183088, 296147529 NP_014149, 6324079 Rad50p ORF Sequence $1500.00
KEGG
sce03440Homologous recombination
sce03450Non-homologous end-joining
sce_M00292MRX complex
WikiPathways
WP377Genes of Meiotic Recombination
Reactome
5369282Cell Cycle
5369789Meiotic recombination
5369396MRN complex relocalizes to nuclear foci
5369372DNA Repair
5369394Double-Strand Break Repair
5369790Meiosis
5369393Homologous Recombination Repair
5369392Homologous recombination repair of replication-independent double-strand breaks
5369395Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
5369397Recruitment of repair and signaling proteins to double-strand breaks
Process
IDNameEvidence
GO:0000706meiotic DNA double-strand break processingTAS
GO:0000722telomere maintenance via recombinationIMP
GO:0000723telomere maintenanceIMP
GO:0000727double-strand break repair via break-induced replicationTAS
GO:0006281DNA repairIEA
GO:0006284base-excision repairIMP
GO:0006303double-strand break repair via nonhomologous end joiningIMP
GO:0006974cellular response to DNA damage stimulusIEA
GO:0007126meiotic nuclear divisionIEA
GO:0007126meiotic nuclear divisionIMP
GO:0032078negative regulation of endodeoxyribonuclease activityIDA
GO:0042138meiotic DNA double-strand break formationTAS
GO:0097552mitochondrial double-strand break repair via homologous recombinationIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005739mitochondrionIDA
GO:0030870Mre11 complexIEA
GO:0030870Mre11 complexIPI
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0003690double-stranded DNA bindingIDA
GO:0003690double-stranded DNA bindingIPI
GO:0003691double-stranded telomeric DNA bindingIDA
GO:0004017adenylate kinase activityIDA
GO:0004017adenylate kinase activityIMP
GO:0004518nuclease activityIEA
GO:0005524ATP bindingIEA
GO:0008270zinc ion bindingIEA
GO:0016787hydrolase activityIEA
GO:0016887ATPase activityIDA
GO:0016887ATPase activityISS
GO:0042162telomeric DNA bindingIDA
GO:0043047single-stranded telomeric DNA bindingIDA
GO:0046872metal ion bindingIEA
GO:0051880G-quadruplex DNA bindingIDA
GeneCards RAD50
UniProt P12753
SGD S000005194

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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