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Sequence in raw or FASTA format:

Database:

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RAD50 Rad50p [Saccharomyces cerevisiae S288c ]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001183088 Saccharomyces cerevisiae S288c Rad50p (RAD50), mRNA. GenEZ ORF Cloning On-demand $1699.00 25

*Business Day

Related Services

Gene Symbol RAD50
Entrez Gene ID 855471
Full Name Rad50p
Synonyms
General protein information
Names
Rad50p
NP_014149.1
  • Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress
Gene Type protein-coding
Organism Saccharomyces cerevisiae S288c ()
Genome

XIV

Summary
Disorder

MIM:

mRNA Protein Product Sequence Price Select
NM_001183088, 296147529 NP_014149, 6324079 Rad50p ORF Sequence $1500.00
KEGG
sce03440Homologous recombination
sce03450Non-homologous end-joining
sce_M00292MRX complex
WikiPathways
WP377Genes of Meiotic Recombination
Reactome
5369282Cell Cycle
5369789Meiotic recombination
5369396MRN complex relocalizes to nuclear foci
5369372DNA Repair
5369394Double-Strand Break Repair
5369790Meiosis
5369393Homologous Recombination Repair
5369392Homologous recombination repair of replication-independent double-strand breaks
5369395Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
5369397Recruitment of repair and signaling proteins to double-strand breaks
Process
IDNameEvidence
GO:0000706meiotic DNA double-strand break processingTAS
GO:0000722telomere maintenance via recombinationIMP
GO:0000723telomere maintenanceIMP
GO:0000727double-strand break repair via break-induced replicationTAS
GO:0006281DNA repairIEA
GO:0006284base-excision repairIMP
GO:0006303double-strand break repair via nonhomologous end joiningIMP
GO:0006974cellular response to DNA damage stimulusIEA
GO:0007126meiotic nuclear divisionIEA
GO:0007126meiotic nuclear divisionIMP
GO:0032078negative regulation of endodeoxyribonuclease activityIDA
GO:0042138meiotic DNA double-strand break formationTAS
GO:0097552mitochondrial double-strand break repair via homologous recombinationIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005739mitochondrionIDA
GO:0030870Mre11 complexIEA
GO:0030870Mre11 complexIPI
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0003690double-stranded DNA bindingIDA
GO:0003690double-stranded DNA bindingIPI
GO:0003691double-stranded telomeric DNA bindingIDA
GO:0004017adenylate kinase activityIDA
GO:0004017adenylate kinase activityIMP
GO:0004518nuclease activityIEA
GO:0005524ATP bindingIEA
GO:0008270zinc ion bindingIEA
GO:0016787hydrolase activityIEA
GO:0016887ATPase activityIDA
GO:0016887ATPase activityISS
GO:0042162telomeric DNA bindingIDA
GO:0043047single-stranded telomeric DNA bindingIDA
GO:0046872metal ion bindingIEA
GO:0051880G-quadruplex DNA bindingIDA
GeneCards RAD50
UniProt P12753
SGD S000005194

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the RAD50 gene?

The RAD50 gene provides instructions for making a protein that is involved in several critical cellular functions, including the repair of damaged DNA.

The RAD50 protein binds to strands of damaged DNA and holds the broken ends together during the repair process. It interacts with two other proteins, produced from the MRE11A and NBN genes, as part of a larger protein complex. These proteins work together to mend broken strands of DNA, which prevents cells from accumulating genetic damage that can trigger them to divide uncontrollably. By repairing damaged DNA, the MRE11A/RAD50/NBN complex helps maintain the stability of a cell's genetic information.

The MRE11A/RAD50/NBN complex interacts with the protein produced from the ATM gene, which plays an essential role in recognizing broken strands of DNA and coordinating their repair. DNA can be damaged by agents such as toxic chemicals or radiation, and breaks in DNA strands also occur naturally when chromosomes exchange genetic material in preparation for cell division.

Interactant

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