Sequence in raw or FASTA format:
RAD50 Rad50p [Saccharomyces cerevisiae S288c ]
|Entrez Gene ID||855471|
|General protein information||
|Organism||Saccharomyces cerevisiae S288c ()|
|WP377||Genes of Meiotic Recombination|
|5369396||MRN complex relocalizes to nuclear foci|
|5369394||Double-Strand Break Repair|
|5369393||Homologous Recombination Repair|
|5369392||Homologous recombination repair of replication-independent double-strand breaks|
|5369395||Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks|
|5369397||Recruitment of repair and signaling proteins to double-strand breaks|
|GO:0000706||meiotic DNA double-strand break processing||TAS|
|GO:0000722||telomere maintenance via recombination||IMP|
|GO:0000727||double-strand break repair via break-induced replication||TAS|
|GO:0006303||double-strand break repair via nonhomologous end joining||IMP|
|GO:0006974||cellular response to DNA damage stimulus||IEA|
|GO:0007126||meiotic nuclear division||IEA|
|GO:0007126||meiotic nuclear division||IMP|
|GO:0032078||negative regulation of endodeoxyribonuclease activity||IDA|
|GO:0042138||meiotic DNA double-strand break formation||TAS|
|GO:0097552||mitochondrial double-strand break repair via homologous recombination||IMP|
|GO:0003690||double-stranded DNA binding||IDA|
|GO:0003690||double-stranded DNA binding||IPI|
|GO:0003691||double-stranded telomeric DNA binding||IDA|
|GO:0004017||adenylate kinase activity||IDA|
|GO:0004017||adenylate kinase activity||IMP|
|GO:0008270||zinc ion binding||IEA|
|GO:0042162||telomeric DNA binding||IDA|
|GO:0043047||single-stranded telomeric DNA binding||IDA|
|GO:0046872||metal ion binding||IEA|
|GO:0051880||G-quadruplex DNA binding||IDA|
What is the normal function of the RAD50 gene?
The RAD50 gene provides instructions for making a protein that is involved in several critical cellular functions, including the repair of damaged DNA.
The RAD50 protein binds to strands of damaged DNA and holds the broken ends together during the repair process. It interacts with two other proteins, produced from the MRE11A and NBN genes, as part of a larger protein complex. These proteins work together to mend broken strands of DNA, which prevents cells from accumulating genetic damage that can trigger them to divide uncontrollably. By repairing damaged DNA, the MRE11A/RAD50/NBN complex helps maintain the stability of a cell's genetic information.
The MRE11A/RAD50/NBN complex interacts with the protein produced from the ATM gene, which plays an essential role in recognizing broken strands of DNA and coordinating their repair. DNA can be damaged by agents such as toxic chemicals or radiation, and breaks in DNA strands also occur naturally when chromosomes exchange genetic material in preparation for cell division.
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