ADAM21 ADAM metallopeptidase domain 21 [Homo sapiens (human)]
| Gene Symbol | ADAM21 |
| Entrez Gene ID | 8747 |
| Full Name | ADAM metallopeptidase domain 21 |
| Synonyms | ADAM 21, ADAM31, MGC125389 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
14 14q24.1 |
| Summary | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene lacks introns and its expression is testis-specific. [provided by RefSeq]. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: 603713 |
| mRNA | NM_003813, 15812182 |
| Protein | NP_003804, 11497040 |
| Product | disintegrin and metalloproteinase domain-containing protein 21 preproprotein |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | ADAM21 | NP_003804.1 |
| Pan troglodytes (chimpanzee) | ADAM21 | XP_001145699.1 |
| Canis lupus familiaris (dog) | ADAM21 | XP_537500.2 |
| Bos taurus (cattle) | ADAM21 | XP_610880.4 |
| Mus musculus (house mouse) | Adam21 | NP_065063.1 |
| ID | Name | Evidence |
| GO:0006508 | proteolysis | IEA |
| GO:0007338 | single fertilization | TAS |
Component
| ID | Name | Evidence |
| GO:0016020 | membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0004222 | metalloendopeptidase activity | IEA |
| GO:0008233 | peptidase activity | IEA |
| GO:0008237 | metallopeptidase activity | TAS |
| GO:0008270 | zinc ion binding | IEA |
| GO:0046872 | metal ion binding | IEA |
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