A2LD1 AIG2-like domain 1 [Homo sapiens (human)]
| Gene Symbol | A2LD1 |
| Entrez Gene ID | 87769 |
| Full Name | AIG2-like domain 1 |
| Synonyms | GGACT |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
13 13q32.3 |
| Summary | The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a free alkylamine. Two transcript variants encoding the same protein have been found for this gene. |
| Disorder | MIM: 613378 |
| mRNA | NM_033110, 304284847 |
| Protein | NP_149101, 34147453 |
| Product | gamma-glutamylaminecyclotransferase |
| RefSeq Status | REVIEWED |
| mRNA | NM_001195087, 304284845 |
| Protein | NP_001182016, 304284846 |
| Product | gamma-glutamylaminecyclotransferase |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | A2LD1 | NP_149101.1 |
| Canis lupus familiaris (dog) | A2LD1 | XP_542653.2 |
| Mus musculus (house mouse) | A2ld1 | NP_663441.1 |
| Rattus norvegicus (Norway rat) | A2ld1 | NP_001020805.1 |
| Gallus gallus (chicken) | A2LD1 | XP_416969.1 |
| Danio rerio (zebrafish) | zgc:92115 | NP_001004544.1 |
| Danio rerio (zebrafish) | zgc:154024 | NP_001071185.1 |
| Danio rerio (zebrafish) | zgc:162208 | NP_001083029.1 |
| Drosophila melanogaster (fruit fly) | Tina-1 | NP_611983.2 |
| ID | Name | Evidence |
| GO:0042219 | cellular modified amino acid catabolic process | IDA |
Function
| ID | Name | Evidence |
| GO:0003839 | gamma-glutamylcyclotransferase activity | IDA |
| GO:0008415 | acyltransferase activity | IEA |
| GO:0016740 | transferase activity | IEA |
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