Search Tips

  • THAT   AND
  • THAT   AND


ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_003899 Homo sapiens Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 1, mRNA. Full Length $2281.05
ORF Sequence $562.89
NM_145735 Homo sapiens Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 2, mRNA. Full Length $2457.90
ORF Sequence $681.21
NM_001113511 Homo sapiens Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 3, mRNA. Full Length $2486.25
ORF Sequence $699.48
NM_001113512 Homo sapiens Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 4, mRNA. Full Length $2418.75
ORF Sequence $655.98
NM_001113513 Homo sapiens Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 5, mRNA. Full Length $1734.60
ORF Sequence $562.89


Gene Symbol ARHGEF7
Entrez Gene ID 8874
Full Name Rho guanine nucleotide exchange factor (GEF) 7
Synonyms BETA-PIX, COOL-1, COOL1, DKFZp686C12170, DKFZp761K1021, KIAA0142, KIAA0412, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q34
Summary Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq].
Disorder

MIM: 605477
mRNA NM_003899, 166064031
Protein NP_003890, 4505573
Product rho guanine nucleotide exchange factor 7 isoform a
RefSeq Status REVIEWED
mRNA NM_145735, 166064032
Protein NP_663788, 22027528
Product rho guanine nucleotide exchange factor 7 isoform b
RefSeq Status REVIEWED
mRNA NM_001113511, 166064033
Protein NP_001106983, 166064034
Product rho guanine nucleotide exchange factor 7 isoform c
RefSeq Status REVIEWED
mRNA NM_001113512, 166064035
Protein NP_001106984, 166064036
Product rho guanine nucleotide exchange factor 7 isoform d
RefSeq Status REVIEWED
mRNA NM_001113513, 166064037
Protein NP_001106985, 166064038
Product rho guanine nucleotide exchange factor 7 isoform a
RefSeq Status REVIEWED
KEGG
hsa04810Regulation of actin cytoskeleton
WikiPathways
WP51Regulation of Actin Cytoskeleton
WP69T Cell Receptor Signaling Pathway
WP185Integrin-mediated cell adhesion
Pathway Interaction Database
fak_pathwaySignaling events mediated by focal adhesion kinase
cdc42_reg_pathwayRegulation of CDC42 activity
aurora_a_pathwayAurora A signaling
cdc42_pathwayCDC42 signaling events
pi3kcipathwayClass I PI3K signaling events
erbb1_internalization_pathwayInternalization of ErbB1
rac1_reg_pathwayRegulation of RAC1 activity
Reactome
REACT_11044Signaling by Rho GTPases
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_19184GPCR downstream signaling
REACT_18407G alpha (12/13) signalling events
REACT_11061Signalling by NGF
REACT_13776p75 NTR receptor-mediated signalling
REACT_12484EGFR downregulation
REACT_9417Signaling by EGFR
REACT_14797Signaling by GPCR
REACT_13638NRAGE signals death through JNK
REACT_11051Rho GTPase cycle
Homo sapiens (human)ARHGEF7NP_663788.1
Pan troglodytes (chimpanzee)ARHGEF7XP_509742.2
Canis lupus familiaris (dog)ARHGEF7XP_542671.2
Bos taurus (cattle)ARHGEF7XP_602674.4
Mus musculus (house mouse)Arhgef7NP_059098.2
Rattus norvegicus (Norway rat)Arhgef7NP_446192.1
Gallus gallus (chicken)ARHGEF7XP_416958.2
Danio rerio (zebrafish)arhgef7aNP_001116707.1
Caenorhabditis eleganspix-1NP_510297.2
Process
IDNameEvidence
GO:0006915apoptosisEXP
GO:0007165signal transductionTAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007264small GTPase mediated signal transductionTAS
GO:0008624induction of apoptosis by extracellular signalsEXP
GO:0035023regulation of Rho protein signal transductionIEA
GO:0042059negative regulation of epidermal growth factor receptor signaling pathwayTAS
GO:0043065positive regulation of apoptosisIMP
GO:0043615astrocyte cell migrationIEA
GO:0048011nerve growth factor receptor signaling pathwayTAS
GO:0051056regulation of small GTPase mediated signal transductionTAS
Component
IDNameEvidence
GO:0005622intracellularIEA
GO:0005737cytoplasmIEA
GO:0005829cytosolEXP
GO:0005829cytosolTAS
GO:0005925focal adhesionIEA
GO:0030426growth coneIEA
Function
IDNameEvidence
GO:0005085guanyl-nucleotide exchange factor activityEXP
GO:0005089Rho guanyl-nucleotide exchange factor activityTAS
GO:0005515protein bindingIPI
GeneCards ARHGEF7
PDB 2L3G, 1BY1, 1ZSG
UniProt Q14155
MIM 605477
Ensembl ENSG00000102606
HGNC 15607
HPRD 05688

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

Secured Online Quotation
Email: gene@genscript.com
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262 1-732-885-5878