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ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001113511 Homo sapiens Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 3, mRNA. ORF Sequence $699.48
Peptide Services
Antibody Services
Protein Services
NM_001113512 Homo sapiens Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 4, mRNA. ORF Sequence $655.98
Peptide Services
Antibody Services
Protein Services
NM_001113513 Homo sapiens Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 5, mRNA. ORF Sequence $562.89
Peptide Services
Antibody Services
Protein Services
NM_003899 Homo sapiens Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 1, mRNA. ORF Sequence $562.89
Peptide Services
Antibody Services
Protein Services
NM_145735 Homo sapiens Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 2, mRNA. ORF Sequence $681.21
Peptide Services
Antibody Services
Protein Services


Gene Symbol ARHGEF7
Entrez Gene ID 8874
Full Name Rho guanine nucleotide exchange factor (GEF) 7
Synonyms BETA-PIX, COOL-1, COOL1, DKFZp686C12170, DKFZp761K1021, KIAA0142, KIAA0412, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q34

Summary Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605477

mRNA Protein Product Sequence Price Select
NM_001113511, 166064033 NP_001106983, 166064034 rho guanine nucleotide exchange factor 7 isoform c Full Length $2486.25
ORF Sequence $699.48
NM_001113512, 166064035 NP_001106984, 166064036 rho guanine nucleotide exchange factor 7 isoform d Full Length $2418.75
ORF Sequence $655.98
NM_001113513, 166064037 NP_001106985, 166064038 rho guanine nucleotide exchange factor 7 isoform a Full Length $1734.60
ORF Sequence $562.89
NM_003899, 166064031 NP_003890, 4505573 rho guanine nucleotide exchange factor 7 isoform a Full Length $2281.05
ORF Sequence $562.89
NM_145735, 166064032 NP_663788, 22027528 rho guanine nucleotide exchange factor 7 isoform b Full Length $2457.90
ORF Sequence $681.21
KEGG
hsa04810Regulation of actin cytoskeleton
WikiPathways
WP51Regulation of Actin Cytoskeleton
WP185Integrin-mediated cell adhesion
Pathway Interaction Database
cdc42_pathwayCDC42 signaling events
rac1_reg_pathwayRegulation of RAC1 activity
fak_pathwaySignaling events mediated by focal adhesion kinase
erbb1_internalization_pathwayInternalization of ErbB1
pi3kcipathwayClass I PI3K signaling events
cdc42_reg_pathwayRegulation of CDC42 activity
aurora_a_pathwayAurora A signaling
Reactome
REACT_13638NRAGE signals death through JNK
REACT_14797Signaling by GPCR
REACT_11051Rho GTPase cycle
REACT_115871Signaling by EGFR in Cancer
REACT_12484EGFR downregulation
REACT_9417Signaling by EGFR
REACT_11044Signaling by Rho GTPases
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_116125Disease
REACT_19184GPCR downstream signaling
REACT_18407G alpha (12/13) signalling events
REACT_11061Signalling by NGF
REACT_13776p75 NTR receptor-mediated signalling
REACT_111102Signal Transduction
Homo sapiens (human)ARHGEF7NP_663788.1
Pan troglodytes (chimpanzee)ARHGEF7XP_003314260.1
Macaca mulatta (Rhesus monkey)ARHGEF7XP_002800879.1
Canis lupus familiaris (dog)ARHGEF7XP_542671.3
Bos taurus (cattle)ARHGEF7XP_002692038.1
Mus musculus (house mouse)Arhgef7NP_001106989.1
Gallus gallus (chicken)ARHGEF7XP_003640579.1
Danio rerio (zebrafish)arhgef7aNP_001116707.1
Caenorhabditis eleganspix-1NP_510297.2
GeneCards ARHGEF7
PDB 2L3G, 1BY1, 1ZSG
UniProt Q14155
MIM 605477
Ensembl ENSG00000102606
HGNC 15607
HPRD 05688

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
rho guanine nucleotide exchange factor 7
Names
rho guanine nucleotide exchange factor 7
PAK-interacting exchange factor beta
guanine nucleotide exchange factor 7
SH3 domain-containing proline-rich protein

Interactant

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