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EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22714 NM_001034116 Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu22903 NM_015636 Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu27281 NM_172195 Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu35652 XM_005264632 PREDICTED: Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu35653 XM_006712132 PREDICTED: Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu22714C NM_001034116 Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu22903C NM_015636 Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu27281C NM_172195 Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu35652C XM_005264632 PREDICTED: Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu35653C XM_006712132 PREDICTED: Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol EIF2B4
Entrez Gene ID 8890
Full Name eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Synonyms EIF-2B, EIF2B, EIF2Bdelta
General protein information
Preferred Names
translation initiation factor eIF-2B subunit delta
Names
translation initiation factor eIF-2B subunit delta
eIF-2B GDP-GTP exchange factor subunit delta
translation initiation factor eIF-2b delta subunit
eukaryotic translation initiation factor 2B subunit 4 delta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p23.3

Summary Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 606687

Leukoencephaly with vanishing white matter, 603896 (3);

mRNA Protein Product Sequence Price Select
NM_001034116, 78000157 NP_001029288, 78000158 translation initiation factor eIF-2B subunit delta isoform 2 ORF Sequence $550.00
NM_015636, 78000155 NP_056451, 78000156 translation initiation factor eIF-2B subunit delta isoform 3 ORF Sequence $550.00
NM_172195, 187607322 NP_751945, 187607323 translation initiation factor eIF-2B subunit delta isoform 1 ORF Sequence $550.00
XM_005264632, 530368257 XP_005264689, 530368258 translation initiation factor eIF-2B subunit delta isoform X1 ORF Sequence $550.00
XM_006712132, 578803251 XP_006712195, 578803252 translation initiation factor eIF-2B subunit delta isoform X2 ORF Sequence $550.00
KEGG
hsa03013RNA transport
WikiPathways
WP107Translation Factors
Reactome
REACT_71Gene Expression
REACT_2159Eukaryotic Translation Initiation
REACT_2099Cap-dependent Translation Initiation
REACT_1815Recycling of eIF2:GDP
REACT_1014Translation
REACT_17015Metabolism of proteins
Homo sapiens (human)EIF2B4NP_001029288.1
Pan troglodytes (chimpanzee)EIF2B4XP_515356.2
Macaca mulatta (Rhesus monkey)EIF2B4XP_001094256.2
Canis lupus familiaris (dog)EIF2B4XP_860642.1
Bos taurus (cattle)EIF2B4NP_001029716.1
Mus musculus (house mouse)Eif2b4NP_034252.2
Rattus norvegicus (Norway rat)Eif2b4NP_446402.1
Gallus gallus (chicken)EIF2B4XP_423512.2
Danio rerio (zebrafish)eif2b4NP_001014383.1
Arabidopsis thaliana (thale cress)AT5G38640NP_198680.1
Xenopus (Silurana) tropicalis (western clawed frog)eif2b4NP_001072364.1
Process
IDNameEvidence
GO:0001541ovarian follicle developmentIMP
GO:0006412translationTAS
GO:0006413translational initiationIDA
GO:0006413translational initiationTAS
GO:0006417regulation of translationNAS
GO:0006446regulation of translational initiationIBA
GO:0009408response to heatISS
GO:0009408response to heatTAS
GO:0009749response to glucoseISS
GO:0010467gene expressionTAS
GO:0014003oligodendrocyte developmentIMP
GO:0019509L-methionine salvage from methylthioadenosineIBA
GO:0032057negative regulation of translational initiation in response to stressISS
GO:0042552myelinationIMP
GO:0043434response to peptide hormoneISS
GO:0043547positive regulation of GTPase activityIDA
GO:0043547positive regulation of GTPase activityIMP
GO:0044267cellular protein metabolic processTAS
GO:0045947negative regulation of translational initiationIBA
GO:0051716cellular response to stimulusIDA
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0005851eukaryotic translation initiation factor 2B complexIDA
Function
IDNameEvidence
GO:0003743translation initiation factor activityIDA
GO:0005085guanyl-nucleotide exchange factor activityIDA
GO:0005085guanyl-nucleotide exchange factor activityIMP
GO:0005515protein bindingIPI
GO:0031369translation initiation factor bindingISS
GO:0046523S-methyl-5-thioribose-1-phosphate isomerase activityIBA
GeneCards EIF2B4
UniProt Q9UI10
Vega OTTHUMG00000151927
MIM 606687
Ensembl ENSG00000115211
HGNC 3260
HPRD 09459

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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