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EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001034116 Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_015636 Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_172195 Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005264632 PREDICTED: Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006712132 PREDICTED: Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (EIF2B4), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol EIF2B4
Entrez Gene ID 8890
Full Name eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Synonyms EIF-2B, EIF2B, EIF2Bdelta
General protein information
Preferred Names
translation initiation factor eIF-2B subunit delta
Names
translation initiation factor eIF-2B subunit delta
eIF-2B GDP-GTP exchange factor subunit delta
translation initiation factor eIF-2b delta subunit
eukaryotic translation initiation factor 2B subunit 4 delta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p23.3

Summary Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 606687

Leukoencephaly with vanishing white matter, 603896 (3);

mRNA Protein Product Sequence Price Select
NM_001034116, 78000157 NP_001029288, 78000158 translation initiation factor eIF-2B subunit delta isoform 2 ORF Sequence $550.00
NM_015636, 78000155 NP_056451, 78000156 translation initiation factor eIF-2B subunit delta isoform 3 ORF Sequence $550.00
NM_172195, 187607322 NP_751945, 187607323 translation initiation factor eIF-2B subunit delta isoform 1 ORF Sequence $550.00
XM_005264632, 530368257 XP_005264689, 530368258 translation initiation factor eIF-2B subunit delta isoform X1 ORF Sequence $550.00
XM_006712132, 578803251 XP_006712195, 578803252 translation initiation factor eIF-2B subunit delta isoform X2 ORF Sequence $550.00
KEGG
hsa03013RNA transport
WikiPathways
WP107Translation Factors
Reactome
REACT_71Gene Expression
REACT_2159Eukaryotic Translation Initiation
REACT_2099Cap-dependent Translation Initiation
REACT_1815Recycling of eIF2:GDP
REACT_1014Translation
REACT_17015Metabolism of proteins
Homo sapiens (human)EIF2B4NP_001029288.1
Pan troglodytes (chimpanzee)EIF2B4XP_515356.2
Macaca mulatta (Rhesus monkey)EIF2B4XP_001094256.2
Canis lupus familiaris (dog)EIF2B4XP_860642.1
Bos taurus (cattle)EIF2B4NP_001029716.1
Mus musculus (house mouse)Eif2b4NP_034252.2
Rattus norvegicus (Norway rat)Eif2b4NP_446402.1
Gallus gallus (chicken)EIF2B4XP_423512.2
Danio rerio (zebrafish)eif2b4NP_001014383.1
Arabidopsis thaliana (thale cress)AT5G38640NP_198680.1
Xenopus (Silurana) tropicalis (western clawed frog)eif2b4NP_001072364.1
Process
IDNameEvidence
GO:0001541ovarian follicle developmentIMP
GO:0006412translationTAS
GO:0006413translational initiationIDA
GO:0006413translational initiationTAS
GO:0006417regulation of translationNAS
GO:0006446regulation of translational initiationIBA
GO:0009408response to heatISS
GO:0009408response to heatTAS
GO:0009749response to glucoseISS
GO:0010467gene expressionTAS
GO:0014003oligodendrocyte developmentIMP
GO:0019509L-methionine salvage from methylthioadenosineIBA
GO:0032057negative regulation of translational initiation in response to stressISS
GO:0042552myelinationIMP
GO:0043434response to peptide hormoneISS
GO:0043547positive regulation of GTPase activityIDA
GO:0043547positive regulation of GTPase activityIMP
GO:0044267cellular protein metabolic processTAS
GO:0045947negative regulation of translational initiationIBA
GO:0051716cellular response to stimulusIDA
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0005851eukaryotic translation initiation factor 2B complexIDA
Function
IDNameEvidence
GO:0003743translation initiation factor activityIDA
GO:0005085guanyl-nucleotide exchange factor activityIDA
GO:0005085guanyl-nucleotide exchange factor activityIMP
GO:0005515protein bindingIPI
GO:0031369translation initiation factor bindingISS
GO:0046523S-methyl-5-thioribose-1-phosphate isomerase activityIBA
GeneCards EIF2B4
UniProt Q9UI10
Vega OTTHUMG00000151927
MIM 606687
Ensembl ENSG00000115211
HGNC 3260
HPRD 09459

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the EIF2B4 gene?

The EIF2B4 gene provides instructions for making one of five parts of a protein called eIF2B, specifically the delta subunit of this protein. The eIF2B protein helps regulate overall protein production (synthesis) in the cell by interacting with another protein, eIF2. The eIF2 protein is called an initiation factor because it is involved in starting (initiating) protein synthesis.

Under some conditions, eIF2B increases protein synthesis by helping to recycle molecules called GTP, which carry energy to the initiation factor. Under other conditions, it slows protein synthesis by binding tightly to the initiation factor, which converts the eIF2B protein into an inactive form and prevents recycling of GTP.

Proper regulation of protein synthesis is vital for ensuring that the correct levels of protein are available for the cell to cope with changing conditions. For example, cells must synthesize protein much faster if they are multiplying than if they are in a resting state.

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