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EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22319 NM_014239 Homo sapiens eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa (EIF2B2), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu22319C NM_014239 Homo sapiens eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa (EIF2B2), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol EIF2B2
Entrez Gene ID 8892
Full Name eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Synonyms EIF-2Bbeta, EIF2B
General protein information
Preferred Names
translation initiation factor eIF-2B subunit beta
Names
translation initiation factor eIF-2B subunit beta
S20I15
S20III15
eIF-2B GDP-GTP exchange factor subunit beta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q24.3

Summary This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011].
Disorder

MIM: 606454

Leukoencephalopathy with vanishing white matter, 603896 (3);

mRNA Protein Product Sequence Price Select
NM_014239, 261244916 NP_055054, 7657058 translation initiation factor eIF-2B subunit beta ORF Sequence $269.00
KEGG
hsa03013RNA transport
WikiPathways
WP107Translation Factors
Reactome
REACT_71Gene Expression
REACT_2159Eukaryotic Translation Initiation
REACT_2099Cap-dependent Translation Initiation
REACT_1815Recycling of eIF2:GDP
REACT_1014Translation
REACT_17015Metabolism of proteins
Homo sapiens (human)EIF2B2NP_055054.1
Pan troglodytes (chimpanzee)EIF2B2XP_001159118.1
Macaca mulatta (Rhesus monkey)EIF2B2XP_001096586.1
Canis lupus familiaris (dog)EIF2B2XP_547911.3
Bos taurus (cattle)EIF2B2NP_001015593.1
Mus musculus (house mouse)Eif2b2NP_663420.1
Rattus norvegicus (Norway rat)Eif2b2NP_114447.2
Gallus gallus (chicken)EIF2B2NP_001006481.1
Danio rerio (zebrafish)eif2b2NP_998068.1
Drosophila melanogaster (fruit fly)eIF2B-betaNP_570020.1
Arabidopsis thaliana (thale cress)AT3G07300NP_001030655.1
Xenopus (Silurana) tropicalis (western clawed frog)eif2b2NP_001164986.1
Process
IDNameEvidence
GO:0001541ovarian follicle developmentIMP
GO:0006412translationTAS
GO:0006413translational initiationIDA
GO:0006413translational initiationTAS
GO:0006446regulation of translational initiationIBA
GO:0006446regulation of translational initiationTAS
GO:0007417central nervous system developmentIMP
GO:0009408response to heatISS
GO:0009408response to heatTAS
GO:0009749response to glucoseISS
GO:0010467gene expressionTAS
GO:0014003oligodendrocyte developmentIMP
GO:0019509L-methionine salvage from methylthioadenosineIBA
GO:0042552myelinationIMP
GO:0043434response to peptide hormoneISS
GO:0043547positive regulation of GTPase activityIDA
GO:0043547positive regulation of GTPase activityIMP
GO:0044267cellular protein metabolic processTAS
GO:0051716cellular response to stimulusIDA
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0005851eukaryotic translation initiation factor 2B complexIDA
Function
IDNameEvidence
GO:0003743translation initiation factor activityIDA
GO:0005085guanyl-nucleotide exchange factor activityIDA
GO:0005085guanyl-nucleotide exchange factor activityIMP
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0005525GTP bindingIDA
GO:0046523S-methyl-5-thioribose-1-phosphate isomerase activityIBA
GeneCards EIF2B2
UniProt P49770, Q53XC2
Vega OTTHUMG00000171764
MIM 606454
Ensembl ENSG00000119718
HGNC 3258
HPRD 05923

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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