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EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_014239 Homo sapiens eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa (EIF2B2), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

*Business Day

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Gene Symbol EIF2B2
Entrez Gene ID 8892
Full Name eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Synonyms EIF-2Bbeta, EIF2B
General protein information
Preferred Names
translation initiation factor eIF-2B subunit beta
Names
translation initiation factor eIF-2B subunit beta
S20I15
S20III15
eIF-2B GDP-GTP exchange factor subunit beta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q24.3

Summary This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011].
Disorder

MIM: 606454

Leukoencephalopathy with vanishing white matter, 603896 (3);

mRNA Protein Product Sequence Price Select
NM_014239, 261244916 NP_055054, 7657058 translation initiation factor eIF-2B subunit beta ORF Sequence $269.00
KEGG
hsa03013RNA transport
WikiPathways
WP107Translation Factors
Reactome
REACT_71Gene Expression
REACT_2159Eukaryotic Translation Initiation
REACT_2099Cap-dependent Translation Initiation
REACT_1815Recycling of eIF2:GDP
REACT_1014Translation
REACT_17015Metabolism of proteins
Homo sapiens (human)EIF2B2NP_055054.1
Pan troglodytes (chimpanzee)EIF2B2XP_001159118.1
Macaca mulatta (Rhesus monkey)EIF2B2XP_001096586.1
Canis lupus familiaris (dog)EIF2B2XP_547911.3
Bos taurus (cattle)EIF2B2NP_001015593.1
Mus musculus (house mouse)Eif2b2NP_663420.1
Rattus norvegicus (Norway rat)Eif2b2NP_114447.2
Gallus gallus (chicken)EIF2B2NP_001006481.1
Danio rerio (zebrafish)eif2b2NP_998068.1
Drosophila melanogaster (fruit fly)eIF2B-betaNP_570020.1
Arabidopsis thaliana (thale cress)AT3G07300NP_001030655.1
Xenopus (Silurana) tropicalis (western clawed frog)eif2b2NP_001164986.1
Process
IDNameEvidence
GO:0001541ovarian follicle developmentIMP
GO:0006412translationTAS
GO:0006413translational initiationIDA
GO:0006413translational initiationTAS
GO:0006446regulation of translational initiationIBA
GO:0006446regulation of translational initiationTAS
GO:0007417central nervous system developmentIMP
GO:0009408response to heatISS
GO:0009408response to heatTAS
GO:0009749response to glucoseISS
GO:0010467gene expressionTAS
GO:0014003oligodendrocyte developmentIMP
GO:0019509L-methionine salvage from methylthioadenosineIBA
GO:0042552myelinationIMP
GO:0043434response to peptide hormoneISS
GO:0043547positive regulation of GTPase activityIDA
GO:0043547positive regulation of GTPase activityIMP
GO:0044267cellular protein metabolic processTAS
GO:0051716cellular response to stimulusIDA
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0005851eukaryotic translation initiation factor 2B complexIDA
Function
IDNameEvidence
GO:0003743translation initiation factor activityIDA
GO:0005085guanyl-nucleotide exchange factor activityIDA
GO:0005085guanyl-nucleotide exchange factor activityIMP
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0005525GTP bindingIDA
GO:0046523S-methyl-5-thioribose-1-phosphate isomerase activityIBA
GeneCards EIF2B2
UniProt P49770, Q53XC2
Vega OTTHUMG00000171764
MIM 606454
Ensembl ENSG00000119718
HGNC 3258
HPRD 05923

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the EIF2B2 gene?

The EIF2B2 gene provides instructions for making one of five parts of a protein called eIF2B, specifically the beta subunit of this protein. The eIF2B protein helps regulate overall protein production (synthesis) in the cell by interacting with another protein, eIF2. The eIF2 protein is called an initiation factor because it is involved in starting (initiating) protein synthesis.

Under some conditions, eIF2B increases protein synthesis by helping to recycle molecules called GTP, which carry energy to the initiation factor. Under other conditions, it slows protein synthesis by binding tightly to the initiation factor, which converts the eIF2B protein into an inactive form and prevents recycling of GTP.

Proper regulation of protein synthesis is vital for ensuring that the correct levels of protein are available for the cell to cope with changing conditions. For example, cells must synthesize protein much faster if they are multiplying than if they are in a resting state.

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