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AP1M1 adaptor-related protein complex 1, mu 1 subunit [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu07051 NM_001130524 Homo sapiens adaptor-related protein complex 1, mu 1 subunit (AP1M1), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu30674 NM_032493 Homo sapiens adaptor-related protein complex 1, mu 1 subunit (AP1M1), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu07051C NM_001130524 Homo sapiens adaptor-related protein complex 1, mu 1 subunit (AP1M1), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu30674C NM_032493 Homo sapiens adaptor-related protein complex 1, mu 1 subunit (AP1M1), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol AP1M1
Entrez Gene ID 8907
Full Name adaptor-related protein complex 1, mu 1 subunit
Synonyms AP47, CLAPM2, CLTNM, MU-1A
General protein information
Preferred Names
AP-1 complex subunit mu-1
Names
AP-1 complex subunit mu-1
mu-adaptin 1
mu1A-adaptin
HA1 47 kDa subunit
clathrin adaptor protein AP47
AP-mu chain family member mu1A
golgi adaptor AP-1 47 kDa protein
clathrin coat assembly protein AP47
clathrin coat-associated protein AP47
adaptor protein complex AP-1 mu-1 subunit
golgi adaptor HA1/AP1 adaptin mu-1 subunit
adaptor-related protein complex 1 mu-1 subunit
clathrin assembly protein complex 1, medium chain
clathrin assembly protein complex AP1, mu subunit
clathrin assembly protein complex 1 medium chain 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.12

Summary The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603535

mRNA Protein Product Sequence Price Select
NM_001130524, 194473723 NP_001123996, 194473724 AP-1 complex subunit mu-1 isoform 1 ORF Sequence $550.00
NM_032493, 194473722 NP_115882, 14210504 AP-1 complex subunit mu-1 isoform 2 ORF Sequence $550.00
KEGG
hsa04142Lysosome
Pathway Interaction Database
ecadherin_nascentaj_pathwayE-cadherin signaling in the nascent adherens junction
Reactome
REACT_19187Clathrin derived vesicle budding
REACT_19400Golgi Associated Vesicle Biogenesis
REACT_19287Lysosome Vesicle Biogenesis
REACT_6185HIV Infection
REACT_6835The role of Nef in HIV-1 replication and disease pathogenesis
REACT_11149Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
REACT_11103Nef mediated downregulation of MHC class I complex cell surface expression
REACT_6288Host Interactions of HIV factors
REACT_11123Membrane Trafficking
REACT_11235trans-Golgi Network Vesicle Budding
REACT_6900Immune System
REACT_75774Adaptive Immune System
REACT_116125Disease
REACT_121399MHC class II antigen presentation
Homo sapiens (human)AP1M1NP_001123996.1
Pan troglodytes (chimpanzee)AP1M1NP_001233313.1
Macaca mulatta (Rhesus monkey)AP1M1XP_001112653.1
Canis lupus familiaris (dog)AP1M1XP_003432952.1
Bos taurus (cattle)AP1M1NP_001039349.2
Mus musculus (house mouse)Ap1m1NP_031482.1
Rattus norvegicus (Norway rat)Ap1m1NP_001037704.1
Gallus gallus (chicken)AP1M1NP_001007887.1
Danio rerio (zebrafish)ap1m3NP_001107913.1
Drosophila melanogaster (fruit fly)AP-47NP_649906.1
Caenorhabditis elegansunc-101NP_001040675.1
Arabidopsis thaliana (thale cress)HAP13NP_176277.1
Arabidopsis thaliana (thale cress)AT1G10730NP_172543.1
Xenopus (Silurana) tropicalis (western clawed frog)ap1m1NP_989033.1
Process
IDNameEvidence
GO:0006886intracellular protein transportIEA
GO:0006892post-Golgi vesicle-mediated transportTAS
GO:0016032viral processTAS
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IITAS
GO:0032438melanosome organizationIMP
GO:0035646endosome to melanosome transportIMP
GO:0050690regulation of defense response to virus by virusTAS
GO:0061024membrane organizationTAS
Component
IDNameEvidence
GO:0000139Golgi membraneTAS
GO:0005765lysosomal membraneTAS
GO:0005829cytosolTAS
GO:0016020membraneIDA
GO:0030131clathrin adaptor complexIEA
GO:0030659cytoplasmic vesicle membraneTAS
GO:0030665clathrin-coated vesicle membraneIEA
GO:0032588trans-Golgi network membraneTAS
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GeneCards AP1M1
UniProt Q9BXS5, B3KNH5, Q59EK3
Vega OTTHUMG00000182323
MIM 603535
Ensembl ENSG00000072958
HGNC 13667
HPRD 04639

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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