Sequence in raw or FASTA format:
AP1M1 adaptor-related protein complex 1, mu 1 subunit [Homo sapiens (human)]
| Gene Symbol | AP1M1 |
| Entrez Gene ID | 8907 |
| Full Name | adaptor-related protein complex 1, mu 1 subunit |
| Synonyms | AP47, CLAPM2, CLTNM, MU-1A |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
19 19p13.12 |
| Summary | The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq]. |
| Disorder | MIM: 603535 |
| mRNA | NM_032493, 194473722 |
| Protein | NP_115882, 14210504 |
| Product | AP-1 complex subunit mu-1 isoform 2 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001130524, 194473723 |
| Protein | NP_001123996, 194473724 |
| Product | AP-1 complex subunit mu-1 isoform 1 |
| RefSeq Status | REVIEWED |
| hsa04142 | Lysosome |
Pathway Interaction Database
| ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
Reactome
| REACT_19187 | Clathrin derived vesicle budding |
| REACT_19287 | Lysosome Vesicle Biogenesis |
| REACT_11149 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| REACT_11123 | Membrane Trafficking |
| REACT_19400 | Golgi Associated Vesicle Biogenesis |
| REACT_6288 | Host Interactions of HIV factors |
| REACT_6835 | The role of Nef in HIV-1 replication and disease pathogenesis |
| REACT_6185 | HIV Infection |
| REACT_11235 | trans-Golgi Network Vesicle Budding |
| REACT_11103 | Nef mediated downregulation of MHC class I complex cell surface expression |
| Homo sapiens (human) | AP1M1 | NP_001123996.1 |
| Pan troglodytes (chimpanzee) | AP1M1 | XP_001172758.1 |
| Canis lupus familiaris (dog) | AP1M1 | XP_865928.1 |
| Mus musculus (house mouse) | Ap1m1 | NP_031482.1 |
| Rattus norvegicus (Norway rat) | Ap1m1 | XP_240364.4 |
| Gallus gallus (chicken) | AP1M1 | NP_001007887.1 |
| Danio rerio (zebrafish) | ap1m1 | XP_002660766.1 |
| Drosophila melanogaster (fruit fly) | AP-47 | NP_649906.1 |
| Caenorhabditis elegans | unc-101 | NP_001040675.1 |
| Arabidopsis thaliana (thale cress) | AT1G10730 | NP_172543.1 |
| Arabidopsis thaliana (thale cress) | HAP13 | NP_176277.1 |
| ID | Name | Evidence |
| GO:0006886 | intracellular protein transport | IEA |
| GO:0006892 | post-Golgi vesicle-mediated transport | EXP |
| GO:0016032 | viral reproduction | TAS |
| GO:0016044 | cellular membrane organization | EXP |
| GO:0016197 | endosome transport | IMP |
| GO:0032438 | melanosome organization | IMP |
| GO:0044419 | interspecies interaction between organisms | IEA |
| GO:0050690 | regulation of defense response to virus by virus | TAS |
Component
| ID | Name | Evidence |
| GO:0000139 | Golgi membrane | TAS |
| GO:0005765 | lysosomal membrane | TAS |
| GO:0005794 | Golgi apparatus | IEA |
| GO:0005829 | cytosol | EXP |
| GO:0005829 | cytosol | TAS |
| GO:0016020 | membrane | IEA |
| GO:0030131 | clathrin adaptor complex | IEA |
| GO:0030659 | cytoplasmic vesicle membrane | TAS |
| GO:0030665 | clathrin coated vesicle membrane | IEA |
| GO:0031410 | cytoplasmic vesicle | IEA |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |