HIST1H2AG histone cluster 1, H2ag [Homo sapiens (human)]
| Gene Symbol | HIST1H2AG |
| Entrez Gene ID | 8969 |
| Full Name | histone cluster 1, H2ag |
| Synonyms | H2A.1b, H2A/p, H2AFP, HIST1H2AI, HIST1H2AK, HIST1H2AL, HIST1H2AM, pH2A/f |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
6 6p22.1 |
| Summary | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq]. |
| Disorder | MIM: |
| mRNA | NM_021064, 227497052 |
| Protein | NP_066408, 10800132 |
| Product | histone H2A type 1 |
| RefSeq Status | REVIEWED |
| hsa05322 | Systemic lupus erythematosus |
| Homo sapiens (human) | HIST1H2AM | NP_003505.1 |
| Homo sapiens (human) | HIST1H2AI | NP_003500.1 |
| Homo sapiens (human) | HIST1H2AK | NP_003501.1 |
| Homo sapiens (human) | HIST1H2AG | NP_066408.1 |
| Homo sapiens (human) | HIST1H2AL | NP_003502.1 |
| Pan troglodytes (chimpanzee) | LOC471909 | XP_001138284.1 |
| Pan troglodytes (chimpanzee) | LOC471894 | XP_527272.2 |
| Pan troglodytes (chimpanzee) | LOC471905 | XP_527283.2 |
| Canis lupus familiaris (dog) | LOC488254 | XP_545376.2 |
| Bos taurus (cattle) | LOC529277 | XP_607721.2 |
| Bos taurus (cattle) | LOC786163 | XP_001250731.1 |
| Bos taurus (cattle) | HIST1H2AG | XP_873992.1 |
| Bos taurus (cattle) | LOC616875 | XP_874094.1 |
| Bos taurus (cattle) | LOC613926 | XP_870241.2 |
| Bos taurus (cattle) | LOC616611 | XP_873767.1 |
| Bos taurus (cattle) | LOC618824 | XP_876240.1 |
| Mus musculus (house mouse) | Hist1h2af | NP_783592.1 |
| Rattus norvegicus (Norway rat) | RGD1564767 | NP_001019453.1 |
| ID | Name | Evidence |
| GO:0006334 | nucleosome assembly | IEA |
Component
| ID | Name | Evidence |
| GO:0000786 | nucleosome | IEA |
| GO:0005634 | nucleus | IEA |
| GO:0005694 | chromosome | IEA |
Function
| ID | Name | Evidence |
| GO:0003677 | DNA binding | IEA |
| GO:0019899 | enzyme binding | IPI |
| GeneCards | HIST1H2AG |
| UniProt | B2R5B3 |
| Ensembl | ENSG00000196787 |
| HGNC | 4737 |
| HPRD | 13654 |
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