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PLCZ1 phospholipase C, zeta 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_033123 Homo sapiens phospholipase C, zeta 1 (PLCZ1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol PLCZ1
Entrez Gene ID 89869
Full Name phospholipase C, zeta 1
Synonyms MGC149685, NYD-SP27, PLCzeta
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].

MIM: 608075

mRNA Protein Product Sequence Price Select
NM_033123, 399498568 NP_149114, 25188201 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 ORF Sequence $700.00
hsa00562Inositol phosphate metabolism
hsa_M00130Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
hsa04114Oocyte meiosis
hsa04070Phosphatidylinositol signaling system
hsa04020Calcium signaling pathway
HUMAN_PWY-6371superpathway of inositol phosphate compounds
HUMAN_PWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
HUMAN_PWY-6367D-myo-inositol-5-phosphate metabolism
Homo sapiens (human)PLCZ1NP_149114.2
Pan troglodytes (chimpanzee)PLCZ1XP_001160159.1
Macaca mulatta (Rhesus monkey)PLCZ1XP_001096056.1
Canis lupus familiaris (dog)PLCZ1XP_543784.3
Bos taurus (cattle)PLCZ1NP_001011680.2
Mus musculus (house mouse)Plcz1NP_473407.2
Rattus norvegicus (Norway rat)Plcz1NP_001012234.1
Gallus gallus (chicken)PLCZ1NP_001034362.1
GeneCards PLCZ1
UniProt Q86YW0
MIM 608075
Ensembl ENSG00000139151
HGNC 19218
HPRD 06996

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
PI-phospholipase C zeta 1
testis-development related NYD-SP27
phosphoinositide phospholipase C-zeta-1


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