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PLCZ1 phospholipase C, zeta 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_033123 Homo sapiens phospholipase C, zeta 1 (PLCZ1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005253519 PREDICTED: Homo sapiens phospholipase C, zeta 1 (PLCZ1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005253520 PREDICTED: Homo sapiens phospholipase C, zeta 1 (PLCZ1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005253521 PREDICTED: Homo sapiens phospholipase C, zeta 1 (PLCZ1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005253522 PREDICTED: Homo sapiens phospholipase C, zeta 1 (PLCZ1), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005253523 PREDICTED: Homo sapiens phospholipase C, zeta 1 (PLCZ1), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005253524 PREDICTED: Homo sapiens phospholipase C, zeta 1 (PLCZ1), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005253526 PREDICTED: Homo sapiens phospholipase C, zeta 1 (PLCZ1), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006719162 PREDICTED: Homo sapiens phospholipase C, zeta 1 (PLCZ1), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol PLCZ1
Entrez Gene ID 89869
Full Name phospholipase C, zeta 1
Synonyms NYD-SP27, PLC-zeta-1, PLCzeta
General protein information
Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
PI-phospholipase C zeta 1
testis-development related NYD-SP27
phosphoinositide phospholipase C-zeta-1
NP_149114.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p12.3

Summary The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Disorder

MIM: 608075

mRNA Protein Product Sequence Price Select
NM_033123, 399498568 NP_149114, 25188201 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 ORF Sequence $700.00
XM_005253519, 530399470 XP_005253576, 530399471 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 ORF Sequence $700.00
XM_005253520, 530399472 XP_005253577, 530399473 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X2 ORF Sequence $700.00
XM_005253521, 530399474 XP_005253578, 530399475 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3 ORF Sequence $700.00
XM_005253522, 530399476 XP_005253579, 530399477 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X4 ORF Sequence $700.00
XM_005253523, 530399478 XP_005253580, 530399479 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X5 ORF Sequence $550.00
XM_005253524, 530399480 XP_005253581, 530399481 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X6 ORF Sequence $550.00
XM_005253526, 530399484 XP_005253583, 530399485 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X8 ORF Sequence $550.00
XM_006719162, 578823072 XP_006719225, 578823073 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X9 ORF Sequence $550.00
KEGG
hsa00562Inositol phosphate metabolism
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04114Oocyte meiosis
hsa_M00130Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
hsa04919Thyroid hormone signaling pathway
BIOCYC
HUMAN_LIPASYN-PWYphospholipases
HUMAN_PWY-6367D-myo-inositol-5-phosphate metabolism
HUMAN_PWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
HUMAN_PWY-6371superpathway of inositol phosphate compounds
Reactome
REACT_111217Metabolism
REACT_150154Inositol phosphate metabolism
REACT_150312Synthesis of IP3 and IP4 in the cytosol
Homo sapiens (human)PLCZ1NP_149114.2
Pan troglodytes (chimpanzee)PLCZ1XP_001160159.1
Macaca mulatta (Rhesus monkey)PLCZ1XP_001095846.2
Canis lupus familiaris (dog)PLCZ1XP_005637152.1
Bos taurus (cattle)PLCZ1NP_001011680.2
Mus musculus (house mouse)Plcz1NP_473407.2
Rattus norvegicus (Norway rat)Plcz1NP_001012234.1
Gallus gallus (chicken)PLCZ1NP_001034362.1
Process
IDNameEvidence
GO:0006816calcium ion transportIEA
GO:0007275multicellular organismal developmentIEA
GO:0007343egg activationIEA
GO:0016042lipid catabolic processIEA
GO:0035556intracellular signal transductionIEA
GO:0043647inositol phosphate metabolic processTAS
GO:0044281small molecule metabolic processTAS
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0005829cytosolTAS
GO:0048471perinuclear region of cytoplasmIEA
Function
IDNameEvidence
GO:0004435phosphatidylinositol phospholipase C activityIEA
GO:0004871signal transducer activityIEA
GO:0005509calcium ion bindingIEA
GeneCards PLCZ1
UniProt Q86YW0
Vega OTTHUMG00000168937
MIM 608075
Ensembl ENSG00000139151
HGNC 19218
HPRD 06996

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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